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Medical Forum / Diseases and Disorders / Cancer / January 2008

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HRT linked with ovarian cancer

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Ilena Rose - 08 Jan 2008 00:51 GMT
http://ilenarose.blogspot.com
Health Lover

Last Modified: 19 Apr 2007
By: Bridgid Nzekwu

http://www.channel4.com/news/articles/society/health/hrt+linked+with+ovarian+can
cer/447862


Women on hormone replacement therapy have a 20 per cent higher risk of
dying from ovarian cancer, says a new report.

The research, from the authoritative Million Women study, suggests
that as many as 1,000 women may have died from ovarian cancer between
1991 and 2005, partly because they were using HRT.

But health experts say that current advice will not change and that
women using HRT should do so for the shortest possible time.

For millions of women it was a liberating treatment. HRT banished hot
flushes, fatigue, mood swings, night sweats and many other symptoms of
the menopause.

In recent years, though, health scares about hormone replacement
therapy put many women off taking it.

Now new research suggests that in some cases using HRT can be fatal.

article continues below...

HRT health scares
There has been a series of health scares associated with HRT -

In 2002 an American study found it increased the risk of heart
attacks, strokes and breast cancer.
In 2003 British research concluded that using HRT over 10 years
doubled the risk of breast cancer.
In April 2007 a new American study revealed that there was NO
increased risk of a heart attack in women in their 50s.

The study found that women on it have a 20 per cent higher risk of
developing ovarian cancer, as well as an increased risk of dying.

And there's a 63 per cent higher combined risk of breast, ovarian and
endometrial cancers.

The study concludes that 1,000 extra British women died between 1991
and 2005.

'What concerns me is they're extending the period of the research from
five years to 14 years, and claiming that a thousand woman would die
over that time. This is really replacing science with sensationalism.'
John Stevenson, Women's Health ConcernThe alarming findings are
already causing controversy among medical experts, some questioning
the science behind them.

The confusion over whether HRT is safe has seen the number of women
using it fall dramatically, from two million in 2001 to one million
four years later.

The British Menopause Society and the Women's Health Initiative are
just two organisations who have in the past condemned contradictory
statistics put out by American researchers.

If the latest research is correct, it means that in Britain one woman
in every 2,500 taking HRT will develop ovarian cancer.

But with so many conflicting messages, many women will remain unsure
as to whether they should continue or even begin treatment.
J - 09 Jan 2008 01:43 GMT
lena Rose wrote:

> The study found that women on it have a 20 per cent higher risk of
> developing ovarian cancer, as well as an increased risk of dying.
[quoted text clipped - 4 lines]
> The study concludes that 1,000 extra British women died between 1991
> and 2005.

http://www.millionwomenstudy.org/index2.html - people filled out questionnaires..
HRT and ovarian cancer

New results from the Million Women Study (April 2007) show a small increase in risk of ovarian
cancer in women taking HRT (see Publications). Such an increased risk had been suspected from
some previous studies, and has now been confirmed with the larger numbers available in the
MWS. The findings come from analyses on 948,576 post-menopausal women in the study, followed
up for about 5 years. Women currently taking HRT were at higher risk of developing and of
dying from ovarian cancer than women not using HRT. Past users were not at increased risk. The
risk in current users was increased about 1.2 fold; for every 1000 women using HRT, 2.6
developed ovarian cancer over 5 years, compared with 2.2 in those not taking HRT. The risk was
the same for oestrogen-only, combined oestrogen-progestagen and other types of HRT (including
tibolone) and did not vary by specific type of oestrogen or progestagen, or between oral and
transdermal (patch) administration.

These results are equivalent to one extra case of ovarian cancer for every 2500 women taking
HRT, and one extra death from ovarian cancer per 3300 women taking HRT, over 5 years.

The results need to be looked at in the context of the other risks and benefits of HRT.

In particular, we can now estimate the overall effect of HRT use on three common cancers in
women: breast cancer, endometrial (womb) cancer and ovarian cancer.

Together, these cancers account for about 4 in 10 cancers in women in the UK.

In women aged 50-69, about 19 of these cancers will develop over 5 years in every 1000 women
not taking HRT.

In women taking HRT we estimate the number of cancers to be increased to about 31.

The overall increased risk is higher in women using combined oestrogen-progestagen HRT (an
increase from 19 to 34 cancers over 5 years) than in women using oestrogen-only HRT (an
increase from 19 to 26 cancers over 5 years) because most of the overall increase is due to an
increase in breast cancer, and users of combined HRT have a higher risk of breast cancer than
users of oestrogen-only HRT.

In general, these new findings on the risk of ovarian cancer in HRT users will not affect
current advice on HRT prescribing, which remains to use HRT for as short a time as possible to
treat menopausal symptoms."

[newsgroups trimmed]
J
 
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