I guess I never posted these..
It's not to give false hope and I sure wish the text wasn't chopped off,
because it makes it very hard for me to concentrate and try to read it and
analyze exactly what they're saying (or not) and I can't read the PDF file
due to computer problems..
so FWIW..
J
http://www.cjns.org/25augtoc/long.html
Long-Term Survivors With a Revised Histological Diagnosis
The prognosis for patients with glioblastoma multiforme (GBM) is very poor;
the median survival with the best available treatment is only twelve months
and the survival rate has changed little in the past twenty years.1,2
This study was designed to determine 1) the frequency of LTGBMS in a
population, and 2) to identify which patient, treatment or tumor
characteristics predicted which GBM patient became a LTGBMS. Information
regarding long-term treatment effects and revised histologic diagnoses of
putative LTGBMS was also recorded.
There were seven patients (2.4%) who survived more than three years whose
histologic diagnosis was revised during our review (Table 4). These did not
meet the criteria of GBM and were excluded from our analysis. As expected,
the largest excluded group of tumors were either malignant oligo-
http://virtualtrials.com/fink/ltgbms.pdf
Long-term Glioblastoma Multiforme Survivors: a Population-based Study
Can. J. Neurol. Sci. 1998; 25: 197-201
I can't copy and paste from it..
One important implication of this study is that a re-evaluation of the
original histology be considered when a GBM patient with a long survival is
encountered. Most of our putative GBM patients with long-term survival are
initially misdiagnosed; others report similar findings.9,23 This is not
unexpected as several tumors may superficially resemble a GBM
histologically5,13,15 and, now that malignant oligodendrogliomas have been
recognized as being highly chemo-sensitive,24 gliomas with necrosis are
more carefully examined and not necessarily called GBM. The most common
revised diagnosis in our patients and others5 was malignant
oligodendroglioma (pure or mixed); others have found more indolently
growing tumors such as pleomorphic xanthoastrocytoma13 in long term
survivors.
I just added these so a person can see what they say for prognostics and
other aspects of this diagnosis.
http://brain.mgh.harvard.edu/PatientGuide.htm
Glioblastoma multiforme and anaplastic gliomas: A patient guide
http://www.emedicine.com/neuro/topic147.htm
Glioblastoma multiforme
Synonyms and related keywords: GBM, grade IV astrocytoma, grade IV glioma,
high-grade astrocytoma, high-grade glioma
Alayne - 12 Jan 2004 09:47 GMT
> I guess I never posted these..
> It's not to give false hope and I sure wish the text wasn't chopped off,
[quoted text clipped - 3 lines]
> so FWIW..
> J
.
Thanks J,
It is probably just as well that I never read these before!!
Alayne
Albron2 - 25 Jan 2004 07:05 GMT
Anyone has more info on this or on GBM in general?
I am looking for GBM patients or their relatives to get a sense of what's real.
Please, help.
R.
J - 25 Jan 2004 09:34 GMT
> Anyone has more info on this or on GBM in general?
> I am looking for GBM patients or their relatives to get a sense of what's real.
Hi,
What's real is if indeed it is GBM, it's the most aggressive type of brain tumour.
http://www.csmc.edu/printer.asp?pg_id=5305
Glioblastoma Multiforme is the highest grade glioma (grade 4) tumor and is the most
malignant form of astrocytomas. These tumors originate in the brain.
General symptoms of this type of tumor are the same as for brain tumors. Specific
symptoms will depend on the size and location of the glioblastoma multiforme.
Treatment of a brain tumor depends on the nature of the tumor, how rapidly it is
growing, what symptoms it is causing and where it is located. Radiation therapy is
required to treat gliomas. Chemotherapy also benefits some patients with such
tumors.
Only about one out of every four patients with this type of tumor survives two
years. Prospects are better when:
The patient is younger than 45
All or most of the tumor can be removed
The tumor turns out to be an anaplastic astrocytoma, which is one stage less severe
than gliobastoma multiforme
(and I'm adding..how early or late the diagnosis, depends on the survival time).
More here:
http://www.braintumor.org/patient_info/surviving/tumor_types/gliomas.html
http://www.emedicine.com/neuro/topic147.htm
http://brain.mgh.harvard.edu/PatientGuide.htm
http://www.cancerbacup.org.uk/info/brain/brain-8.htm
There are some reported RARE longer term survival.
http://www.cjns.org/25augtoc/long.html
There are two posters (sometimes here).
Alayne, whose husband chose conventional treatments and died last Fall.
Diagnosed/posted here around Dec/02.
And marc whose wife has chosen no conventional treatments due to concerns about
side effects and quality of life.
He reports that she's doing well so far, but we haven't had an update of a brain
scan. She had no confirming biopsy.
I cannot remember if Alayne's husband had a biopsy or not. Neither could be
surgically removed due to the location.
Hope this helps you get started in your research. Since you say so little (whether
it's you or someone close to you).
Let us know if we can be of further assist or other questions.
If it's you with the diagnosis, post away, we'll be here for you. (reading, caring,
replying)
Best,
J
J - 25 Jan 2004 09:43 GMT
> Anyone has more info on this or on GBM in general?
> I am looking for GBM patients or their relatives to get a sense of what's real.
>
> Please, help.
I forgot this http://www.methodisthealth.com/cancer/brain.htm
It shows a sideview of the brain and (possible) symptoms as relate to location of
the tumour.
Hope this helps
J
Alayne - 25 Jan 2004 10:25 GMT
> Anyone has more info on this or on GBM in general?
> I am looking for GBM patients or their relatives to get a sense of what's real.
>
> Please, help.
> R.
Hi, I'm Alayne, I lost my husband at the end of August last year to a GBM4.
What would you like to know?? I am not a medic but I was his main carer
throughout his illness and will try to answer any questions you may have.
Alayne