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Medical Forum / Diseases and Disorders / Cancer / January 2008Mets. in liver from breast cancer, female 43 yrs - treatment?
She is 43 years and has a tumour with the size of a fist in her right breast and was just going to start chemo for 20 weeks in order to reduce the tumour to an oprationable size (80% in size less than now), when her doctor discovered spread to her liver! What is the best treatment she can get from this standpoint? What about transplatation? We've heard about tests with patients whos have spread to liver from colon cancer, but what about mets from breast cancer? Other treatments? Appreciate your help out there! Roland Norway > She is 43 years and has a tumour with the size of a fist in her right > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 12 lines] > Roland > Norway Metastatic disease to the liver is always a sign of widespread mets in breast cancer. Surgery is not an option. The situation with colon cancer is rather special Treatment will certainly be chemotherapy, but will be palliative. > > She is 43 years and has a tumour with the size of a fist in her right > > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 17 lines] > rather special > Treatment will certainly be chemotherapy, but will be palliative. No surgery for the breast, then, Steph? Would the picture be better if she was her2neu+ ? J >> > She is 43 years and has a tumour with the size of a fist in her right >> > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 23 lines] > Would the picture be better if she was her2neu+ ? > J Surgery might be appropriate for issues of local control, but not cure her2neu doesn't matter Hello J, J I hope this e-mail get to you. It is regarding her stage4 inoperable Metatstatic Breast Cancer. By now she has had her 5th cemo (separated by 3 weeks) She gets "Cyclophosphamide - Epirubicin - Flourouracil" each time. After the last chemo, she got a bad reaction in the sence of water in her right lung, embolus in the artery from the lungs (poor O2 uptake) and some trouble with the liver. Her doctor says that all this was because of the chemo and they will now replace the Epuribicin with Taxotere. The tomour is now reduced to half of what it was in October and the spots on the liver have not developed (good) but there are mets to her right lung, that they hope wil be stopped by the new "cocktail". Now to my questions: 1) I read somewhere once about approx 260 patients with stage-4 mets breast cancer of what some 50 patients survived 3 years and 16 were still living after 15 years (I think in that order). Do you have ref. such statistics and where I can find it? 2) In Dec 2006 I read a long posting "Surviving Cancer" posted by Eli_S and signed by Mrs "TQ". She had survived cancer for almost 50 years and gave us her own story. Have you heard of this and do you know if she is living today? Roland old posting--------------------------------------------------------- On Mon, 15 Oct 2007 18:52:35 -0400, you wrote: |> > She is 43 years and has a tumour with the size of a fist in her right |> > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 22 lines] |Would the picture be better if she was her2neu+ ? |J |> > She is 43 years and has a tumour with the size of a fist in her right |> > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 22 lines] |Would the picture be better if she was her2neu+ ? |J > Hello J, > [quoted text clipped - 27 lines] > > Roland Hello Roland, TQ asked Eli to post this if he didn't hear from her by Dec 12th. http://www.health-forums.com/alt-support-cancer/tq-surviving-cancer-5934.html She had multiple cancer diagnoses over almost 5 decades and was battling one again so maybe she didn't make it. Some of her cancers might have been early stage and cured with surgery, like skin cancers. No, I've not heard from her again and there's nothing more on her webpage. Metastatic disease (Stage IV) is incurable. The five-year survival rate is about 5 to 10%. I think the ones with metastatic cancer (Stage IV) who survive the longest have only low-volume amounts of cancer in the bone. If it's found at the stage where it's spread throughout the body, it's less optimistic. So remember that chemo is palliative to reduce the size of the tumor and make the person feel better if the tumor's causing symptoms and in so doing may result in some prolongation of life. In the common cancers, like your wife's, chemo does not reduce tumors to nothing; just too small to be seen on scans, for a while. When they say "stopped", they mean stopped from growing for a while. So please make sure your wife has breaks so she is able to the things she loves to do, visit old friends, family, travel or whatever pleases her. You too ! Let us know how you're doing - you're important as well. Best, J > She is 43 years and has a tumour with the size of a fist in her right > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 12 lines] > Roland > Norway Treatment for metstatic cancer is systemic....more chemo. Some opt for pallative care treatment of symptoms only, Bone Marrow transplant was shown not to be effective for breast cancer. http://www.webmd.com/breast-cancer/guide/bone-marrow-transplantation I am assuming if she was HER2 positive she would be getting it preoperatively. Here is a link to a email group for breast mets http://www.bcmets.org/ > I am assuming if she was HER2 positive she would be getting it > preoperatively. Why? > > I am assuming if she was HER2 positive she would be getting it > > preoperatively. > > Why? Neo adjunctive chemo is targeted for the tumor, if the tumor tested positive for HER/2 that would be the treatment choice, It seems to be accepted treatment worldwide http://www.nature.com/bjc/journal/v94/n2/full/6602930a.html That is why I made that conclusion but with the limited information given it was just a guess. >> > I am assuming if she was HER2 positive she would be getting it >> > preoperatively. [quoted text clipped - 8 lines] > That is why I made that conclusion but with the limited information > given it was just a guess. "neoadjunctive treatment"? We're talking metastatic disease here, not localised and potentially curable disease. The patient he posted about is stage 4, your irrelevant trial was for patients with stage 2 and 3 disease who were being treated for cure. Why on earth do you post ill-informed nonsense after ill-informed nonsense? > >> "Alex" <usenetg...@gmail.com> wrote in message > [quoted text clipped - 18 lines] > The patient he posted about is stage 4, your irrelevant trial was for > patients with stage 2 and 3 disease who were being treated for cure. I didn't post any trial but an consumer article about Bone Marrow Transplant and how it is NOT effective for stage IV breast cancer, it is NOT an option. > Why on earth do you post ill-informed nonsense after ill-informed nonsense? I think if you read the post the patient was diagnosed with a large tumor, with the goal of reducing the tumor to save the breast.....the standard of care is to test the tumor for hormone status and her/2. Yes the initial goal was to cure the cancer and have surgery which is stage 2 o3 3.J asked about Herceptin which I added that would have been tested and treated during the initial curative treatment. I said palliative care is an option for stage IV, while some elect to have chemo. Chemo has been shown to prolong life in Stage IV Breast Cancer. It is a whole new ball game when diagnosis stage IV. Do you not give herceptin to patients for neoadjuctive therapy prior to surgery? It is give in the US to for breast sparing surgery. >> >> "Alex" <usenetg...@gmail.com> wrote in message >> [quoted text clipped - 40 lines] > Do you not give herceptin to patients for neoadjuctive therapy prior > to surgery? It is give in the US to for breast sparing surgery. For patients who already have metastatic disease in the liver? > >> >> "Alex" <usenetg...@gmail.com> wrote in message > >> [quoted text clipped - 36 lines] > > For patients who already have metastatic disease in the liver? There's a her2neu forum http://her2support.org/ if Alex wants to check it. herceptin.com does not mention neoadjuvant nor does cancer care ontario that I could see http://www.cancercare.on.ca/pdf/pebc1-15s.pdf nor wikipedia, that I could see , if someone wants to check http://en.wikipedia.org/wiki/Herceptin It sounds like it potentiates the effect of other chemotherapies in certain people? J > For patients who already have metastatic disease in the liver? Yes NCCN guidelines suggest the use. >> For patients who already have metastatic disease in the liver? > > Yes NCCN guidelines suggest the use. They certainly DO NOT suggest the use of neoadjuvant chemotherapy for patients with liver metastases, so either you misunderstood them, or you're telling porkies. Would you like to post the citation? Steph schreef: > >>> For patients who already have metastatic disease in the liver? [quoted text clipped - 7 lines] > > She misunderstood the neoadjuvant part. Anne > Steph schreef: >> [quoted text clipped - 9 lines] > > Anne A little knowledge is a dangerous thing > Steph schreef:> "xela56" <noacco...@nw.nl> wrote in message > >news:aPidndQwP6ofW4vanZ2dnUVZ_gudnZ2d@comcast.com... [quoted text clipped - 10 lines] > > Anne I didn't misunderstand the tern neoadjuctive , according to the post, the woman was newly diagnosed with breast cancer getting neo adjuc chemo then diagnosed with liver mets. > > "Alex" <usenetg...@gmail.com> wrote in message > > [quoted text clipped - 21 lines] > Transplant and how it is NOT effective for stage IV breast cancer, it > is NOT an option. The OP was asking about a liver transplant, not a bone marrow transplant. J > > Why on earth do you post ill-informed nonsense after ill-informed nonsense? > I didn't post any trial but an consumer article about Bone Marrow > Transplant and how it is NOT effective for stage IV breast cancer, it > is NOT an option. The OP was asking about a liver transplant, not a bone marrow transplant. J > > Why on earth do you post ill-informed nonsense after ill-informed nonsense? I appreciate yourpostings and follow with interest. Now the chemo has started and the 3 weeks to come will be very "exciting". Guess the reaction to the first chemo will indicate the result of the following 8 treatments on to the end of December?! Regards Roland >> I didn't post any trial but an consumer article about Bone Marrow >> Transplant and how it is NOT effective for stage IV breast cancer, it [quoted text clipped - 14 lines] > Regards > Roland Response to chemo in breast cancer, especially inflammatory, is sometimes dramatic, but often more slow. I don't think you'll be able to draw any conclusions necessarily from one cycle. Tried to reach you on e-mail but nil. After my posting here I got some info from a Finish friend, who has been treated for oral cancer for +20 years. He sent me some info regarding treatments and diets etc. Now my question: Would it be ok for you, if I send his comments to you via e-mail for you to have a look at? I have sorted the info into three categories (treatments, cototoxic agents and diet/health foods, so it should be easy to get a quick overview. Roland |>> I didn't post any trial but an consumer article about Bone Marrow |>> Transplant and how it is NOT effective for stage IV breast cancer, it [quoted text clipped - 18 lines] |dramatic, but often more slow. I don't think you'll be able to draw any |conclusions necessarily from one cycle. > Tried to reach you on e-mail but nil. > [quoted text clipped - 8 lines] > > Roland Sounds like questions for her oncologist. Steph does not email. Alternatively, run it by alt.support.cancer.breast please. J > > Tried to reach you on e-mail but nil. > [quoted text clipped - 13 lines] > Alternatively, run it by alt.support.cancer.breast please. > J Oral cancer on the breast cancer support group. It does not make sense. > > > Tried to reach you on e-mail but nil. > > [quoted text clipped - 15 lines] > > Oral cancer on the breast cancer support group. It does not make sense. He did not write "got some info for". He wrote "got some info from". We're not in an oral cancer thread. Look at the topic/subject line. That's how I drew my conclusion. J > Tried to reach you on e-mail but nil. > [quoted text clipped - 8 lines] > > Roland You really should be discussing these with your wife's oncologist. My email isn't my email, if you know what I mean Steph, Yes I'm going to discuss it with ther oncologist, but he is on holiday for another week. This is a small country with few oncologist available! So just wanted a (2nd) evaluation :-) But ok, I get the point - thank you Roland Norway |> Tried to reach you on e-mail but nil. |> [quoted text clipped - 11 lines] |You really should be discussing these with your wife's oncologist. |My email isn't my email, if you know what I mean Today I had a short conversation with her oncologist on phone. This is the brief information I got: Diagnose codes: C48.7 - C50.9 - C79.5. The chemo therapy consist of the following drugs in combination for 8 cycles: Cyclophosphamide - Epirubicin - Flourouracil, intravnniously injected. Any comments? Regards Roland |Steph, | [quoted text clipped - 21 lines] ||You really should be discussing these with your wife's oncologist. ||My email isn't my email, if you know what I mean > Today I had a short conversation with her oncologist on phone. This is > the brief information I got: [quoted text clipped - 9 lines] > Regards > Roland Pretty standard palliative chemotherapy in the circumstances. > She is 43 years and has a tumour with the size of a fist in her right > breast and was just going to start chemo for 20 weeks in order to [quoted text clipped - 12 lines] > Roland > Norway Try to treat cancer with flavonoids!!! |
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