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Medical Forum / Diseases and Disorders / Cancer / September 2007Crucial Role of Iron Accumulation
Med Hypotheses 2001 Nov;57(5):539-43 The possible crucial role of iron accumulation combined with low tryptophan, zinc and manganese in carcinogenesis. Johnson S. Iron can react with citric acid, interfering with the Krebs cycle, hence with oxidative phosphorylation. Free iron (Fe) can cause considerable oxidative damage both through Fenton reactions and by activating xanthine oxidase, which produces both superoxide (O(2-)) and uric acid (abundant in many cancers). It can also react with lactic acid, reducing its elimination and increasing the acidity of the cytoplasm. Fe can also wreak havoc by reacting with tryptophan, the least abundant and most delicate essential amino acid, which is necessary for the production of serotonin and other substances required by the immune system to fight cancer. On the other hand, in the presence of iron, the tryptophan metabolite quinolinate causes intense lipid peroxidation. Similarly, several other carcinogenic metabolites of tryptophan are particularly dangerous in the presence of Fe. Excess Fe may also interfere with manganese superoxide dismutase and impair the initiation of apoptosis by the mitochondrion, rendering the cells impervious to all the signals to undergo apoptosis from without and from within the cell. Moreover, Fe may also play a crucial role on telomere repair, by activating telomerase. Therefore, by inhibiting apoptosis and enhancing chromosome repair, Fe may bestow immortality upon the cancer cell. Furthermore, Fe is one of the triggers for mitosis. Therefore, increased Fe levels may be essential for the rapid growth characteristic of many malignancies. In turn, the rapid growth further depletes resources from the healthy tissues, exacerbating the deficiencies of the other elements and reducing the ability to fight the malignancy. Copyright 2001 Harcourt Publishers Ltd. PMID: 11735307 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "Free iron (Fe) can cause considerable oxidative damage" What are the two major ways the body regulates free iron? Jesus ate a mediterranean diet. >> On Sep 27, 7:37 am, ferr...@paris.com wrote: "Free iron (Fe) can cause considerable oxidative damage" What are the two major ways the body regulates free iron? << You mean .. labile iron pool .. ? .. is that what you mean .. Let's see .. Let's type that in .. and see .. ? That would be the easy thing to do .. Short pause here to make it appear as if I really looked this up ... -- -- Sooo .. free iron / labile iron pool .. is "unregulated iron" .. I guess if it is .. unregulated .. means the body does NOT .. regulate it .. ? Yep .. -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >> Free iron (Fe) can cause considerable oxidative damage" > What are the two major ways the body regulates free iron? How about this? [_] 1: World J Gastroenterol. 2007 Sep 21;13(35):4737-45. Liver-gut axis in the regulation of iron homeostasis. The human body requires about 1-2 mg of iron per day for its normal functioning, and dietary iron is the only source for this essential metal. Since humans do not possess a mechanism for the active excretion of iron, the amount of iron in the body is determined by the amount absorbed across the proximal small intestine and, consequently, intestinal iron absorption is a highly regulated process. In recent years, the liver has emerged as a central regulator of both iron absorption and iron release from other tissues. It achieves this by secreting a peptide hormone called hepcidin that acts on the small intestinal epithelium and other cells to limit iron delivery to the plasma. Hepcidin itself is regulated in response to various systemic stimuli including variations in body iron stores, the rate of erythropoiesis, inflammation and hypoxia, the same stimuli that have been known for many years to modulate iron absorption. This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption. PMID: 17729395 [PubMed - in process] |
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