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Medical Forum / Diseases and Disorders / Cancer / December 2003Hydrocodone question.
The prefix "hydro" means water. When it is used with "hydrocodone" what is it referring to? How the med is manufactured, metablized? Thanks. "passedpast" <passedpast@aol.com> on 29 Dec 2003 suggested: > The prefix "hydro" means water. When it is used with "hydrocodone" > what is it referring to? How the med is manufactured, metablized? > Thanks. This isn't always true. When "hydro" is used in chemical terminology it usually means "hydrogen", as in hydrocarbons. However, when marketing folks grab hold of things, anything can happen. Now, I couldn't find an image of the structure of "codone", but I did find one of "hydrocodone" and you can see it here: http://opioids.com/hydrocodone/hydrocodone.jpg. I also found the structure of "Oxyodone", which you can see here: http://opioids.com/oxycodone/oxycodone.jpg. There is a very subtle difference between the two, and actually, as a chemist, I would properly term "Oxycodone" as "Hydroxycodone", since "hydroxy" means the combined hydrogen-oxygen, or OH, group that you see where in the hydrocodone image is just a hydrogen. However, marketers probabaly thought that "hydrocodone" and "hydroxycodone" would be too confusingly similar, so they dropped the "hydro" part of the second chemical. I hope that helps somewhat. --Douglas my understanding of Hydrocodone (as well as from what I've read in my PDR) is that it contains either acetominophen (tylenol) or Ibuprofen (the active ingredient in Advil)... I believe Vicodin is the one with the Ibuprofen.... Lorcet is the one with tylenol. I also know that special attention needs to be made for how the liver functions while on these meds long term. I"d have to go and look it up again but this is just off the top of my head.  Signature"Many have forgotten this truth, but you must not forget it. You remain responsible, forever, for what you have tamed." ~Antoine de Saint-Exupery > "passedpast" <passedpast@aol.com> on 29 Dec 2003 suggested: > [quoted text clipped - 21 lines] > > --Douglas > my understanding of Hydrocodone (as well as from what I've read in my PDR) > is that it contains either acetominophen (tylenol) or Ibuprofen (the active > ingredient in Advil)... I believe Vicodin is the one with the Ibuprofen.... > Lorcet is the one with tylenol. I also know that special attention needs to > be made for how the liver functions while on these meds long term. I"d have > to go and look it up again but this is just off the top of my head. http://www.rxlist.com/cgi/generic/hydrocod_cp.htm Vicodin Hydrocodone and Acetaminophen Pharmacokinetics The behavior of the individual components is described below. Hydrocodone: Following a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was 23.6 ± 5.2 ng/ml. Maximum serum levels were achieved at 1.3 ± 0.3 hours and the half-life was determined to be 3.8 ± 0.3 hours. Hydrocodone exhibits a complex pattern of metabolism including O-demethylation, N-demethylation, and 6-keto reduction to the corresponding 6-a- and 6-b-hydroxy-metabolites. (See OVERDOSAGE for toxicity information.) Acetaminophen: Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug. (See OVERDOSAGE for toxicity information.) Anyway, here's the list that comes up when searching "hydrocodone" (because the mixes vary with hydrocodone) http://www.rxlist.com/cgi/rxlist.cgi?drug=hydrocodone HTH J "slykitten" <noway@inyour.dreams> on 29 Dec 2003 suggested: > my understanding of Hydrocodone (as well as from what I've read in > my PDR) is that it contains either acetominophen (tylenol) or > Ibuprofen (the active ingredient in Advil)... That is not correct. Hydrocodone is a separate chemical compound. It is often combined with other NSAIDs (Non-Steroidal Anti-Inflammatory Drug) such as tylenol or ibuprofen or aspirin. > I believe Vicodin is > the one with the Ibuprofen.... Lorcet is the one with tylenol. Vicodin (in the US) is combined with Tylenol (acetominophen). I don't know the trade names of the ones mixed with other NSAIDs off the top of my head, but they are easily looked up in many places. --Douglas well, according to you what I said is technically correct because I didn't say for absolute certainty what any chemical compound is.... I was also just going off the top of my memory and it's been a good 5 years since I've actually had to work with any of these meds so things obviously have changed.... I do not, however, appreciate you insinuating that I"m stupid. in my response (which was obviously a friggin mistake) I stated that Hydrocodone may also have either the Ibuprofen or Acetominophen and explained that they're the respective active ingredients in Advil and Tylenol.... I also explained that with the one with Tylenol, special attention MIGHT be needed for liver function as Acetominophen can cause liver damage if too much is consumed. now, I'm not some hot shot chemist as you claim to be but what I can see is that nurses get no respect here on this group... first I'm called an idiot by steph when things went bad for my grandma and now you're calling me stupid because i'm not a big shot chemist... well the hell with it... YOU're obviously right and *I'M* obviously wrong.... does that make you feel better? Signature"Many have forgotten this truth, but you must not forget it. You remain responsible, forever, for what you have tamed." ~Antoine de Saint-Exupery > "slykitten" <noway@inyour.dreams> on 29 Dec 2003 suggested: > [quoted text clipped - 14 lines] > > --Douglas "slykitten" <noway@inyour.dreams> on 29 Dec 2003 suggested: [TOP POSTING FIXED] >> "slykitten" <noway@inyour.dreams> on 29 Dec 2003 suggested: >> [quoted text clipped - 17 lines] > well, according to you what I said is technically correct because I > didn't say for absolute certainty what any chemical compound is.... My objection was to your statement that Hydrocodone CONTAINS acetominophen or ibuprofen. It does not. I then went on to clarify that it is often combined with those other NSAIDs. > I do not, however, appreciate you insinuating that I"m stupid. I certainly did not intend to, nor do I believe I actually did, insinuate any such thing. It is not my desire nor in my nature to denigrate or otherwise harm anyone intentionally. All I wanted to do is provide correct information and clarify things. > I also explained that with the one with Tylenol, special attention > MIGHT be needed for liver function as Acetominophen can cause liver > damage if too much is consumed. That was important information which was correct, and thus I made no comment upon it. > now, I'm not some hot shot chemist as you claim to be but > what I can see is that nurses get no respect here on this group... I did not know you are/were a nurse, and I have no lack of respect for you at all. I simply want to make sure that correct information is being disseminated. When I'm wrong, I do not mind being corrected. > first I'm called an idiot by steph when things went bad for my > grandma and now you're calling me stupid because i'm not a big shot > chemist... I can't speak for anyone but myself, but I know when I posted I had no intent nor desire to call you or anyone else stupid. My only intent was to correct and clarify the information provided. --Douglas > well, according to you what I said is technically correct because I didn't > say for absolute certainty what any chemical compound is.... I was also just [quoted text clipped - 12 lines] > chemist... well the hell with it... YOU're obviously right and *I'M* > obviously wrong.... does that make you feel better? h*ell's bells ! Now I have to 'fess up, slykitten. I've just realized, I've been calling you skykitten ever since you've been posting here. My monitor is small and it's dark in here, that's my excuse and I'm sticking to it. Just for the record, Steph did not call you an idiot. It was around the time your grandma died and then your rabbit took ill. You were having an exchange during Anth's mam's thread about nurses spending time with their patients. You and Steph were having a difference of opinion. Then all those hurting posters jumped in and wrapped their (virtual) loving arms around you. Lowkey, patty-anne, bookbabe, Jill, Anth, Cat in the Hat and many more. http://tinyurl.com/2ueyy Never mind the issues, look at the people (down the sidebar) and remember.... It's been a rough year and more recently very rough time here. And holidays are rough for everyone who has lost a loved one (and I expect for someone in your profession). We're all hurting..but let's remember there are more here, fighting cancer, including Douglas and the OP's wife. In honour of bookbabe...to use one of her phrases...let it go, grasshopper, let it go. ( ( ( slykitten ) ) ) J > > well, according to you what I said is technically correct because I didn't > > say for absolute certainty what any chemical compound is.... I was also just [quoted text clipped - 38 lines] > ( ( ( slykitten ) ) ) > J I've Googled the "hydro" but still can't get an adequate answer. Hydrocodone, granted is Vicodin, but what does the hydro refer to? Another pain med, dilaudid, I do believe, is also called hydromorphine. I'm just confused as to why hydro is used as a prefix. "passedpast" <passedpast@aol.com> on 30 Dec 2003 suggested: > I've Googled the "hydro" but still can't get an adequate answer. > Hydrocodone, granted is Vicodin, but what does the hydro refer to? > Another pain med, dilaudid, I do believe, is also called > hydromorphine. I'm just confused as to why hydro is used as a > prefix. Were you unable to read my original post to your original question? "Hydro" refers to the addition of a Hydrogen atom to the original molecule. I gave you links to two pictures so you could see "HydroCodone" and "OxyCodone", and see how they differed. If you need further guidance, you can right me directly by eliminating "HatesSpam" from my e-mail address. --Douglas P.S. In my previous post, I also explained that OxyCodone should really be called "HydroxyCodone", but my guess is the marketing types thought consumers would be confused. THanks J.... and Douglas.... I didn't mean to be over sensitive.... I also won't make any excuses other than "firsts" are the hardest.... see, one thing I had noticed is that many times, nurses spend a lot of time and emotion with their patients, that's not to discount the emotional connection between doctors and their patients.... Doctors are sometimes just a little too busy to give a lot of individual attention. (reminds me of my 6 week check up after my infant was born.... my poor doc just got paged because another of his patients was getting ready to push! I only got 8 minutes of his time!) it doesn't mean that they care any less or more.... they just care different.... right now, all the hype of the holidays just seems to have disappeared and suddenly, it's as if the exciting roller coaster ride, complete with tunnels, twists, turns and loops is suddenly over in only a matter of mere moments yet it was hyped up for so long.... the fall is hard and the fall is great.... my kids even noticed that I seemed a little sadder than usual..... that's prompted me to get back in touch with my counselor and let her know that once a month might not be what I need right now and that maybe once a week for a while is the best bet. I guess I just didn't realize how much Bookbabe and Lowkey had meant to me when grandma was so sick until I went back and reread their posts to me and others here....I'll never forget Cat in the Hat.... how he stood by his wife.... how sad I felt when I'd read the news.... and even with Stephen's daughter..... I admired her.... still do.... courage, strength.... lots of healing still.... I hate grief.... it's a very long and painful road.... <extending for a handshake to Douglas> sorry.... shouldn't have bit at you... no excuse for it.... Signature"Many have forgotten this truth, but you must not forget it. You remain responsible, forever, for what you have tamed." ~Antoine de Saint-Exupery > > > well, according to you what I said is technically correct because I didn't [quoted text clipped - 39 lines] > ( ( ( slykitten ) ) ) > J > THanks J.... and Douglas.... I didn't mean to be over sensitive.... I also > won't make any excuses other than "firsts" are the hardest.... see, one [quoted text clipped - 19 lines] > her.... still do.... courage, strength.... lots of healing still.... I hate > grief.... it's a very long and painful road.... yes, yes, yes, yes, you got them all tagged in one post... Last week I was just reading that it's after the holidays that often people feel it more.. so do change your counselling for the next few months, I'm pretty sure it will help a lot. Maybe all you'll need is a few weekly sessions and then go to twice monthly, then back to monthly again. Best wishes, dear slykitten. J "slykitten" <noway@inyour.dreams> on 30 Dec 2003 suggested: > <extending for a handshake to Douglas> sorry.... shouldn't have bit > at you... no excuse for it.... Don't worry about! I rarely get emotional or take things personally. I just try to communicate and avoid misunderstandings. Glad this one was able to get cleared up. *hugs* --Douglas =) Thanks again.... Ironically, I used to be at the point in my life where nothing bothered me.... never got emotional, never got angry or upset.... was very "matter-of-fact" and then I had a really bad situation happen when I worked the Oncology unit.... when I was a student, I worked with the veterans. one of my patients had bladder/prostate cancer and was readmitted in agony. he was a DNR as he was fast approaching end stage. I'll never forget that as the end came near, his pain was such that nothing could ease it. when the end finally did come, I'd never seen anything like it.... it really affected me.... I didn't expect that kind of end and it scared me.... especially when I found out about my grandma.... Even now, this group is so supportive.... Signature"Many have forgotten this truth, but you must not forget it. You remain responsible, forever, for what you have tamed." ~Antoine de Saint-Exupery > "slykitten" <noway@inyour.dreams> on 30 Dec 2003 suggested: > [quoted text clipped - 6 lines] > > --Douglas |
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