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Medical Forum / Diseases and Disorders / Cancer / May 2006

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NPC Patient CHY: Week One Completed

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CHY - 20 Feb 2006 03:16 GMT
Hi everybody,

I was going to reply in the roll call thread but I can't figure out how
to reply using Google so I'm starting a new thread.  Sorry but I'm a
little of out it.  I didn't realize that every little thing from
swallowing, sleeping to pouring myself a glass of water would be such a
struggle.  While I got about 10 hours of sleep today, I think I got a
total of six in the two days previous.

Radiation treatment is going fine.  No ill effects yet.  The nodes on
my neck have already shrunk by around 30% to 50% so something's
working.

It's the cisplatin (190 mg) that's getting to me.  I had to be
hospitalized twice this week because of it.  On Wednesday, the cisplain
raised my serum amalyase level to 3215 (the normal value is 130) and
inflammed my pancreas a little bit so I was very nauseous and vomiting
constantly with no real breaks for me to rest.  After giving me five
bags of IV and some meds, they got my level down to 710 and released me
on Thursday afternoon.  All I had to do was drink plenty of clear
fluids to continue flushing out my system.  Unfortunately, because I
was obssessed with getting enough nutrition, I ate too much on Friday
(relatively, I didn't have a big meal, we're talking two tablespoons of
mash potatoes instead of one) and had to go back to the hospital.  This
time, I wasn't vomiting as much but the feeling of vomiting and
constant dry heaves meant I couldn't do much but lean over a bucket for
hours and hours on end.  Again, I got fluids and meds and am now home
trying to recoup enough energy for another week of radiation
treatments.

I speak again with the med onc sometime next week (Thursday I think).
Is there anything he can do to prevent the nausea and the spike in
amalyase next time?  Or is this something I'll just have to live with?
The ER nurse said that it'll probably happen again but just not as
severe.  Myself, I hope it doesn't happen again because the acid from
the vomit is doing more damage to my throat and mouth at this point
than the radiation.  Quitting is not an option but if he had another
chemo drug he could give me or better anti-emetic or if he could safely
change the amount of cisplatin I'm getting then it would be a very
welcome relief.
Alayne - 20 Feb 2006 08:11 GMT
> Hi everybody,
>
[quoted text clipped - 36 lines]
> change the amount of cisplatin I'm getting then it would be a very
> welcome relief.

Sorry to hear that things have been so tough for you, hang in there, we're
all routing for you.

Warm Hugs

Alayne
J - 20 Feb 2006 09:41 GMT
> It's the cisplatin (190 mg) that's getting to me.  I had to be
> hospitalized twice this week because of it.  On Wednesday, the cisplain
[quoted text clipped - 23 lines]
> change the amount of cisplatin I'm getting then it would be a very
> welcome relief.

Can you sleep sitting up, for a while? Perhaps they'll lower the dose a bit
next time.
If you get abdominal pain, be sure to tell them.
Hopefully this is transient and only mild.

See if someone can check baby food section of grocery store for veal baby
food (before anyone gets in an uproar I'm talking about liquified foods for
babies in jars - veal is sometimes easier on the tummy) - mix a bit with a
bit of mashed potatoes.
.
They may also give you an antacid.
And you might benefit from Steph's concoction "liquid mixture of nystatin,
viscous xylocaine and an
anti-inflammatory " (swish, gargle and/or swallow).

In case something here helps you...
J
http://www.emedicine.com/MED/topic1720.htm Last Updated: February 28, 2005
   * The cardinal symptom of acute pancreatitis is abdominal pain, which
is characteristically dull, boring, and steady. Most often, it is located
in the upper abdomen, usually in the epigastric region, but it may be
perceived more on the left or right side, depending on which portion of the
pancreas is involved. The pain radiates to the back in approximately half
of cases.

   * The duration of pain varies but typically lasts more than a day.

   * The pain may be aggravated by eating or lying supine, and it may be
alleviated by fasting or lying on the left side with the knees and hips
flexed.

   * Associated symptoms (eg, anorexia, nausea, vomiting) are common, and
some patients experience diarrhea.

   * Drugs (~1.4%)

         o Considering the small number of patients who develop
pancreatitis compared to the relatively large number who receive
potentially toxic drugs, drug-induced pancreatitis is a relatively rare
occurrence probably related to an unknown predisposition. Fortunately,
drug-induced pancreatitis is usually mild.

         o Drugs definitely associated with acute pancreatitis include
azathioprine, sulfonamides, sulindac, tetracycline, valproic acid,
didanosine, methyldopa, estrogens, furosemide, 6-mercaptopurine,
pentamidine, 5-aminosalicylic acid compounds, corticosteroids, and
octreotide.

         o Drugs probably associated with acute pancreatitis include
chlorothiazide and hydrochlorothiazide, methandienone, metronidazole,
nitrofurantoin, phenformin, piroxicam, procainamide, colaspase,
chlorthalidone, combination cancer chemotherapy drugs (especially
asparaginase), cimetidine, cisplatin, cytosine arabinoside, diphenoxylate,
and ethacrynic acid
Figgertoes - 20 Feb 2006 14:07 GMT
> See if someone can check baby food section of grocery store for veal
> baby food (before anyone gets in an uproar I'm talking about liquified
> foods for babies in jars - veal is sometimes easier on the tummy) -
> mix a bit with a bit of mashed potatoes.
> .
Brilliant!  That's what we fed sick kitties who couldn't keep food down.  
Vet also suggested the lamb for same reason.  To make it more tasty, you
can sprinkle on some garlic powder (digestion friendly) or other herbs, if
that makes it more appealing.  

Hope the next round is easier on you.

Fig
Pen - 20 Feb 2006 14:47 GMT
> Hi everybody,
>
[quoted text clipped - 36 lines]
> safely change the amount of cisplatin I'm getting then it would be a
> very welcome relief.

Sorry to hear how tough it's been CHY!

I had a lot of problems with cisplatin also so the med onc changed me to
carboplatin. Said it was in the same family of chemo drugs, just easier to
take. Might want to ask about that one.

Hang in there!
hugs
Penny
Mike Radcliffe - 20 Feb 2006 21:40 GMT
> I speak again with the med onc sometime next week (Thursday I think).
> Is there anything he can do to prevent the nausea and the spike in
[quoted text clipped - 6 lines]
> change the amount of cisplatin I'm getting then it would be a very
> welcome relief.

Cisplatin is about the most nauseating of drugs. Standard treatment would be
Zofran or Navoban during and for 3-4 days after treatment but sometimes even
these drugs aren't that effective.
 Quitting is always an option because the chemo can often do far worse
things than the disease.
MIKE
J - 20 Feb 2006 23:20 GMT
> >CHY wrote:
> > I speak again with the med onc sometime next week (Thursday I think).
[quoted text clipped - 14 lines]
> things than the disease.
> MIKE

His type of cancer is curable, Mike.
J
Araik Margarian - 31 May 2006 00:55 GMT
>> >CHY wrote:
>> > I speak again with the med onc sometime next week (Thursday I think).
[quoted text clipped - 19 lines]
> His type of cancer is curable, Mike.
> J

By the way, J, do you have any idea about CHY?

Signature

Regards,
Araik Margarian
http://journals.aol.com/aramargar1/MyAmericanDream/

J - 31 May 2006 01:35 GMT
> "By the way, J, do you have any idea about CHY?

No word about CHY, Araik, but I think of you all often.
J
 
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