Cell Biochem Funct. 2006 Jan 30; [Epub ahead of print] Related
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Lipid peroxidation and total antioxidant status in patients with breast
cancer.

Erten Sener D, Gonenc A, Akinci M, Torun M.

Department of Biochemistry, Faculty of Pharmacy, Gazi University,
Ankara, Turkey.

Oxidative stress is considered to be involved in the pathophysiology of
all cancers. The aim of this study is to examine oxidative stress and
antioxidant status in patients with breast cancer by evaluation of the
serum levels of total antioxidant capacity (TAC) and lipid peroxidation
products as malondialdehyde (MDA) and lipid hydroperoxide and to
investigate the relationship between these parameters, oxidative stress
and serum lipids and lipoproteins. In our study, serum TAC, MDA, lipid
hydroperoxide, HDL-cholesterol, VLDL-cholesterol, LDL-cholesterol,
total cholesterol, triacylglycerol (TAG), albumin and uric acid levels
of 56-breast cancer patients in different clinical stages and 18
healthy women were determined. Significantly lower-levels of TAC were
detected in patients with breast cancer in comparison to controls (2.01
+/- 0.01 mmol/l and 2.07 +/- 0.03 mmol/l, respectively, p < 0.05).
Serum MDA levels of the patients were higher compared to the controls
(3.64 +/- 0.25 microM and 2.72 +/- 0.22 microM, respectively, p <
0.05). No significant difference between lipid hydroperoxide levels of
patients and controls was found (0.33 +/- 0.05 microM and 0.32 +/- 0.01
microM, respectively, p > 0.05). These data show that lower TAC and
higher MDA levels i.e. increased oxidative stress may be related to
breast cancer. Copyright (c) 2006 John Wiley & Sons, Ltd.

PMID: 16447143 [PubMed - as supplied by publisher]

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