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Medical Forum / Diseases and Disorders / Cancer / January 2006Iron is important in the pathogenesis of cancer
Asian Pac J Cancer Prev. 2005 Oct-Dec;6(4):505-9. Related Articles, Links Iron, Cholesterol, and the Risk of Cancer in an 18-year Cohort. Wells BJ, Mainous Iii AG, Everett CJ, Gill JM. Department of Family Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195. wellsb@ccf.org. The iron catalyzed oxidation of serum lipids is hypothesized to generate oxidative stress, which appears to play an important role in the pathogenesis of many cancers. Previous research has obtained conflicting results regarding the independent contribution of cholesterol and iron on cancer risk. The purpose of this study was to test for an interaction between iron and cholesterol on cancer risk. The present cohort study was an analysis of the National Health and Nutrition Examination Survey I (NHANES I) database linked with the NHANES I Epidemiologic Follow-up Study. Baseline serum iron and total cholesterol values were obtained on 7,448 adults, who were followed for the development of cancer over 18-21 years. Population weights were applied to create Cox proportional hazard models of time to the development of cancer for the entire U.S. adult population (n=72,602,523). Control variables included: age, race, gender, smoking, body mass index, chronic cough, chronic hepatitis, chronic/recurrent colitis or enteritis, and gastrointestinal bleeding. Independent elevations of either iron or total cholesterol were not significantly related to the development of cancer in the adjusted model. However, the combination of iron and total cholesterol above the 75th percentile was associated with a significant increase in the risk of all cancers (HR 1.39, 95% CI 1.00-1.94). Iron and cholesterol above the 80th and 85th percentiles increased the hazard ratio for cancer further to 1.51 (CI 1.10-2.08) and 1.61 (CI 1.07-2.43), respectively. These results support the theory that the iron induced oxidation of serum lipids is important in the pathogenesis of cancer. PMID: 16436001 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking This idiot has been reported to tosusenet@aol.com for newsgroup abuse with a plea to put an end to his persistent cross-spamming despite frequent requests to stop. > This idiot has been reported to tosusenet@aol.com for newsgroup abuse with > a plea to put an end to his persistent cross-spamming despite frequent > requests to stop. and "c palmer" wrote >i reported him too. But, of course, tosusenet@aol.com no longer accepts complaints, despite being listed on AOL's website as THE place to report newsgroup abuse. Is it any wonder AOL is considered the kiddie pool of ISPs? So, help yourselves out, people -- find other ways to shut down this cross-dressing dimwit. I'm solving MY problem with a PLONK of the TinMan at this point. I.P. >>of course, tosuse...@aol.com no longer accepts complaints, despite being listed on AOL's website as THE place to report newsgroup abuse. Is it any wonder AOL is considered the kiddie pool of ISPs? << Well you must know WHY they don't accept abuse reports .. ? Because if you look at the header of the thread .. ? It says .. cancer .. Now look at the header in your newsgroup .. Does it say .. cancer .. ? It says .. cancer .. Now write to the aolabuse .. and tell them .. "this idiot is posting to newsgroups with irrelevant information .. " .. Now .. wonder out loud WHY aol doesn't listen to .. braindeadmorons .. Figure it out .. ? Betcha didn't ya braindeadmoron .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Well you must know WHY they don't accept abuse reports .. ? > [quoted text clipped - 20 lines] > Who loves ya. > Tom I wonder if Google Groups will still love you after numerous abuse reports, ya braindeadmoron!! And your IP address (207.200.116.135) yields this location.......and AOL tech phone # and email...... OrgName: Netscape Communications Corp. OrgID: NSCP Address: 501 E. Middlefield City: Mountain View StateProv: CA PostalCode: 94043 Country: US NetRange: 207.200.64.0 - 207.200.127.255 CIDR: 207.200.64.0/18 NetName: NETSCAPE-CIDR NetHandle: NET-207-200-64-0-1 Parent: NET-207-0-0-0-0 NetType: Direct Allocation NameServer: NS.NETSCAPE.COM NameServer: NS2.NETSCAPE.COM Comment: ADDRESSES WITHIN THIS BLOCK ARE NON-PORTABLE RegDate: 1996-09-06 Updated: 2001-03-28 RTechHandle: AOL-NOC-ARIN RTechName: America Online, Inc. RTechPhone: +1-703-265-4670 RTechEmail: domains@aol.net >>wonder if Google Groups will still love you after numerous abuse reports, ya braindeadmoron!!<< Yep .. explain to them how posting medical studies to medical newsgroups .. pss you off to no end .. That's a good girl .. No .. I believe that may make you a bread dead moron .. See the thread .. ? I started the thread .. You got a problem WITH the .. thread ..? STAY .. off .. the .. thread .. You 'contributed' .. dck .. So .. shut up and take off .. Netiquette .. baby .. Dig .. ? Betcha don't .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking .. "Heather" quoted a post I had successfully PLONKED, including > <ironjustice@aol.com> wrote in ... >> Well you must know WHY they don't accept abuse reports .. ? >> >> Because if you look at the header of the thread .. ? >> >> It says .. cancer .. Yes ... CANCER. Not BS, not dog squeeze, not SPAM, not SNAKE OIL ... *C* A*N*C*E*R*. You treat your cancer with nails, crystals, and magnets; we'll use science, thank you very much. I.P. On Thee I used Spamcop and it had no trouble reporting him to Google Groups.....forget the AOL crap in the headers......probably forged anyway. groups-abuse@google.com - send reports there. With full headers. Or join up with the free Spamcop service.....I have been reporting jerks like this for eons. www.spamcop.net Auntie Virus/Auntie Spam >> This idiot has been reported to tosusenet@aol.com for newsgroup abuse >> with a plea to put an end to his persistent cross-spamming despite [quoted text clipped - 13 lines] > > I.P. <<snip>> iron chelators may be effective antitumor agents <<snip>> Cancer Invest. 2005;23(8):683-91. Related Articles, Links Cell permeable iron chelators as potential cancer chemotherapeutic agents. Pahl PM, Horwitz LD. University of Colorado Health Sciences Center, Department of Medicine, Denver, CO 80262, USA. Iron is an essential micronutrient for the growth and function of all cells. It is, therefore, an attractive target for chemotherapeutic compounds. Numerous studies in vitro and in vivo provide evidence that iron chelators may be effective antitumor agents. Lipophilic iron chelators that are readily cell permeable and can bind intracellular iron stores may selectively kill cancer cells without damaging normal cells. In this review we discuss the role of iron in cellular processes and how these processes differ between normal and neoplastic cells. We also review the effects on normal and cancer cell growth of several lipophilic iron chelators. Publication Types: Review PMID: 16377587 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Alcohol, iron-associated oxidative stress, and cancer. Alcohol, iron-associated oxidative stress, and cancer. Petersen DR. Department of Pharmaceutical Sciences, Box C238, University of Colorado Health Sciences ... www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=16054986&dopt=Citation - Similar pages Iron, calcium linked to lung cancer High intake of iron, however, has previously been associated with higher risk of colorectal cancer, and although calcium seems to protect against some ... www.nutraingredients-usa.com/ news/ng.asp?id=64320-iron-calcium-lung-cancer - 38k - Cached - Similar pages Dietary Iron and Cancer 8] It is unclear whether the cancer risk associated with elevated transferrin saturation is increased by consumption of high levels of dietary iron in the ... www.medscape.com/viewarticle/502752 - 33k - Cached - Similar pages Iron Also, iron is associated with some risk for heart disease. ... Role of iron in estrogen-induced cancer. Curr Med Chem. 2001;8(7):839-849. ... www.umm.edu/altmed/ConsSupplements/Ironcs.html - 42k - Jan 26, 2006 - Cached - Similar pages Alternative Medicine Review: Heme iron, zinc and upper digestive ... Higher intake of heme iron is associated with higher risk, while higher intake of zinc is associated with lower, risk of upper digestive tract cancer. ... www.findarticles.com/p/articles/ mi_m0FDN/is_3_10/ai_n15858713 - 28k - Cached - Similar pages Iron, Linus Pauling Institute's Micronutrient Information Center Most of the symptoms of iron deficiency are a result of the associated anemia, ... However, the relationship between dietary iron and cancer risk in ... lpi.oregonstate.edu/infocenter/minerals/iron/ - 64k - Jan 27, 2006 - Cached - Similar pages Role of iron in estrogen-induced cancer. A role of iron in hormone-associated cancer in humans offers attractive routes for cancer prevention by regulating metal ion metabolism and interfering with ... www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=11375754&dopt=Abstract - Similar pages AllRefer Health - Iron - Dietary Supplements - Alternative Medicine Individuals with hereditary hemochromatosis are at increased risk for liver cancer (1). This increased risk is associated with an accumulation of iron in ... health.allrefer.com/alternative-medicine/iron-9.html - 32k - Cached - Similar pages Transferrin Saturation, Dietary Iron Intake, and Risk of Cancer ... What was particularly striking was that increased transferrin saturation was associated with a higher cancer risk only when it was combined with a high iron ... www.annfammed.org/cgi/content/full/3/2/131 - Similar pages RedOrbit - Health - Iron and calcium may up risk of lung cancer When the team analyzed the 3 micronutrients separately, iron and calcium were associated with a higher risk of lung cancer but zinc was associated with a ... www.redorbit.com/news/health/318246/ iron_and_calcium_may_up_risk_of_lung_cancer/ - 19k - Cached - Similar pages Iron Dr. Murray; Dietary iron linked to upper GI cancer risk - MSNBC, 12/12/05 - "Consumption of high levels of dietary iron appear to be associated with an ... qualitycounts.com/fpiron.html - 51k - Cached - Similar pages Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking This is a low iron diet designed to lower iron levels in hepatitis patients. http://tinyurl.com/dppft The dietary allowance for Fe, as recommended by the Indian Council of Medical Research is about 28 mg/d for males and about 30 mg/d for females (Gopalan et al. 1989). In our specially formulated diet, we decreased the Fe content of the diet to about 67 mg/d, without compromising the energy and protein content of the diet. This diet was primarily rice-based with casein as the main protein source. It contained the daily allowances for all food groups except for pulses and meat. ---------------------------------------------------------------- The result was very good. ---------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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