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Medical Forum / Diseases and Disorders / Cancer / February 2006

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erbitux side effects

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46erjoe - 26 Jan 2006 17:50 GMT
I know that acne and skin blotching is a side effect of erbitux, but
this is crazy!  I've got zits on top of zits on top of zits. The back
of my head looks like the moon, and in just 6 days of my first
infusion. I can't imagine what I'll look like several months down the
road!. Is there any topical ointment that will reduce this problem?
J - 26 Jan 2006 19:13 GMT
> I know that acne and skin blotching is a side effect of erbitux, but
> this is crazy!  I've got zits on top of zits on top of zits. The back
> of my head looks like the moon, and in just 6 days of my first
> infusion. I can't imagine what I'll look like several months down the
> road!. Is there any topical ointment that will reduce this problem?

Hi Joe,
I guess the acne thing is common
http://www.rxlist.com/cgi/generic3/erbitux_ad.htm
Your onc should know what to do about that.
Lowkey didn't get that, he got fungal under the nails problems.
Let us know how it goes.
J
46erjoe - 27 Jan 2006 18:53 GMT
My onc wouldn't give me today's infusion beause of the severe
reaction. Will wait another week and see. In the meanwhile I was given
anti-biotics. Golly gee, I'm sure that will help (as much as they've
helped me in the past).

Problem is that Erbitux is my last line of defense. I've gone thourgh
all the other drugs. After this, I'll be just sent home to die.

--Joe

>> I know that acne and skin blotching is a side effect of erbitux, but
>> this is crazy!  I've got zits on top of zits on top of zits. The back
[quoted text clipped - 9 lines]
>Let us know how it goes.
>J
J - 28 Jan 2006 12:10 GMT
> My onc wouldn't give me today's infusion beause of the severe
> reaction. Will wait another week and see. In the meanwhile I was given
[quoted text clipped - 5 lines]
>
> --Joe

What a bummer, Joe :(
Can you search the archives of ACOR (colorectal) for Erbitux and cutaneous
then Erbitux and acne
to see what is said there?
Maybe we can talk about your findings vs mine, once I hear back from you.
Meantime, here's ome hugs ( ( (Joe ) ) )
J
46erjoe - 31 Jan 2006 03:30 GMT
Yeah, I've read up as much as I could find on erbitux. Acneform rash
is expected, but I guess my body just doesn't like it much. Anyhow, I
would refuse it in the future on the basis of my reaction to it. I've
been running a fever 100 - 102 for 9 days now. My onc doesn't know
why. Blood cell count was OK. Strange.

I may be eligible for some clinical trial.

On the upside, we bought a nice retirement home close to my big BIG
family and I'll be turning in my resignation  this coming Sunday
morning. So in about 35 days I'll be outahere.

--joe

>> My onc wouldn't give me today's infusion beause of the severe
>> reaction. Will wait another week and see. In the meanwhile I was given
[quoted text clipped - 13 lines]
>Meantime, here's ome hugs ( ( (Joe ) ) )
>J
alex - 31 Jan 2006 04:21 GMT
Hope you enjoy your new home for a very long time....Alex
J - 31 Jan 2006 10:55 GMT
> Yeah, I've read up as much as I could find on erbitux. Acneform rash
> is expected, but I guess my body just doesn't like it much. Anyhow, I
> would refuse it in the future on the basis of my reaction to it. I've
> been running a fever 100 - 102 for 9 days now. My onc doesn't know
> why. Blood cell count was OK. Strange.

Well, cancer can cause a fever but how high, I do not know.
Fever and infection are mentioned by erbitux (and staying out of the sun/UV
rays)
http://erbitux.com/erbitux/home/home.jsp
So it's hard to know what to do about it.
I was concerned that the skin is inside our bodies and that this acne can occur
inside the body (worried about sepsis mentioned on www.rxlist, but maybe that's
those who had bowel performations), but I just read that it (acne can occur)
anywhere, where there's hair follicles and I don't think there's hair follicles
inside the body..but really don't know.

Apparently the acne continues, for some time, according to 2 persons (one
doctor) here
http://www.cancercompass.com/message-board/message/all,1694,0.htm

> I may be eligible for some clinical trial.

I hope so, Joe. I hope so.

> On the upside, we bought a nice retirement home close to my big BIG
> family and I'll be turning in my resignation  this coming Sunday
> morning. So in about 35 days I'll be outahere.

It's comforting to know that you're moving to family.
God bless, Joe
J
J - 06 Feb 2006 19:31 GMT
> Yeah, I've read up as much as I could find on erbitux. Acneform rash
> is expected, but I guess my body just doesn't like it much. Anyhow, I
[quoted text clipped - 3 lines]
>
> I may be eligible for some clinical trial.

hi Joe,
madiba's talking about Erbitux on sci.med.diseases.cancer (in Head and Neck
thread).
He says ("they're saying") the worst reaction = best response
I don't want to give you false hope, but I wonder if you want to pop over and
ask him (if he knows) how a person deals with the acne???
J
J W - 08 Feb 2006 03:43 GMT
erbitux side effects  
Group: alt.support.cancer

I know that acne and skin blotching is a side effect of erbitux, but
this is crazy! I've got zits on top of zits on top of zits. The back of
my head looks like the moon, and in just 6 days of my first infusion. I
can't imagine what I'll look like several months down the road!. Is
there any topical ointment that will reduce this problem?  
and also wrote:
Problem is that Erbitux is my last line of defense. I've gone thourgh
all the other drugs. After this, I'll be just sent home to die.
--Joe


Whatever you find out about  erbitux and your reactions to it, please
come back here and post as many of us including myself will be taking
that drug next if the one we are on now doesn't work and it's important
that we know everything possible about the side effects as it is the
last line of defense for many of us..

Two thoughts that come to mind on the acne subject. One acne is
sometimes indicative of an inner infection and is the body's way of
shedding the toxins by bringing them to the surface via pimples and
sists. Something unrelated to the chemo may be slightly infected and
causing the fever and acne. Check the chemo port out good cause that is
the usual suspect. The other thing that comes to mind is your workplace.
Since the drug says to avoid sunlight. Does your job use flourescent
lights?  they are pretty much the same as sunlight, many folks use them
for indoor plants. Perhaps sunblock and protective clothing may help.
Another dirivitave of sunlight is vitamin D also found in many foods and
dairy prducts. Try cuting back on them and see if it helps.

You also wrote this in another post joe - Problem is that Erbitux is my
last line of defense. I've gone thourgh all the other drugs. After this,
I'll be just sent home to die.

That simply is not true joe, the only person in all creation that knows
if and when you will die is God. As Jesus said to the woman who
clammered through the crowds of people to be near him because she
believed that if she were simply to be able touch his garment she would
be healed, "by your faith you are healed". Refusing to beleive the
statistics and beleiving with all your being in something can and has in
many cases caused healing where none thought it was possible.

I was slapped in the face three days before Christmas with the fact that
I had stage four colon cancer with no warning or symptoms. I was
probably satan's poster child as I was the most egotistical, self
absorbed, self serving sinner that ever walked this earth. I have broken
every commandment and some that weren't written that should have been. I
was a beer guzzling, chain smoking, lying, pitiful excuse for a man, two
ex wives and one current wife I'm sure will agree with that assessment
and probably add some to it. Doctors tell me I got less than one percent
chance of beating it, That I have 6 months with no chemo and 20-24
months with chemo. (I'm taking the chemo)

If a miserable coot like me can get on my knees, spill my guts, cry like
a baby and ask Jesus to forgive me and help me, Anybody can do it. I
gave my whole life to God, gave up all my bad habits. I siad God if it's
my time then so be it but if you can find something here that I can do
to help others, serve you and glorify your name, then cast out this
affliction, tell me what you want me to do and it will be done.

Maybe the doctor's assesment is right, only god knows for sure but I
refuse to beleive it and I will not put all my faith in a bag of
medicine. I will not lose faith if the last line of medical defense
should fail. I put all my faith in the man that created all things. All
things come from God, without him there can be nothing and all things
are possible through him, believe this.. Scripture says if a man have
faith he can say to a mountain, lift thyself up and cast hyself into the
sea and it will be done.

If you beleive this God will heal you either directly by his hand or
indirectly through treatments but he will heal you. If in two years I'm
still here, I'll be living proof, if not you can write me off as a
nutcase but at least in the meantime the belief and faith is giving me
strength and helping me not to give in to doom and gloom. If you give in
to them, satan will take you right down to the bottom and sap all the
life out of you so beleive with all your heart in something and don't
let that faith waiver for even a second no matter what gets thrown on
you.
46erjoe - 12 Feb 2006 01:31 GMT
>erbitux side effects  
>Group: alt.support.cancer
[quoted text clipped - 20 lines]
>sists. Something unrelated to the chemo may be slightly infected and
> etc etc

JW: Thanks for the long reply. I've been a believer for a long long
time and my reply about being sent home to die was rhetorical. I'm
coming up on 2 1/2 years after first diagnosis of stage 4 CRC, so it
looks like I will do better than average, for which I am most
grateful. Life is a gift and I did nothing to deserve it or earn it
and I have no complaints if the Lord takes me sooner or later. The way
I see it God is in control not cancer.

That being said, the side effects of treatment can be a real bummer. I
have 25 more days of work at my church (I'm a clergyman) and I told my
onc that I don't want any more erbitux for now. I do not want my
people to have their last memory of me as a pizza-face. I'll resume
the erbitux after retirement, but at a much lower dosage, when I don't
care how I look. Then we'll go from there.

It's nice though to be off chemo for a while. Strength comes back. No
more puking and crapping. The rash is pretty much gone now and I feel
pretty normal. Last scan showed growth + new tumors. I have had the
opportunity to share my story and to help a lot of folks in the area
who are cancer patients and that has been a real blessing. There is a
reason for everything and if my words comforted anyone then having
this cancer has redemptive purposes.

My onc said that my rash was the worst case he had ever seen. He did
say however that that was a sure sign that it was doing what it was
supposed to do. He said he'd be more concerned if there was NO rash.

I do sit under flourescent lighting all day in my office so I will
discontinue that as an experiment. Nothing to lose, right?

In the meanwhile, JW, I wish you the best. Your story is very moving.
You should publish it or share it in some public arena. My story, by
the way can be found at http://www.cbcwoodbury.org/pastorjoe.html

Best regards,

Joe
 
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