Home | Contact Us | FAQ | Search & Site Map | Link to Us
Sign In | Join | Other 45 Sites in Network
Home
Discussion Groups
General
GeneralCardiologyVisionDentistryPharmacyLaboratoryNutritionAlternative
Diseases and Disorders
AIDSAlzheimer'sArthritisAsthmaCancerBreast CancerDiabetesEpilepsyGlaucomaHepatitisHerpesLupusProstate BPHProstate CancerProstatitisSinusitisTinnitus

Medical Forum / Diseases and Disorders / Cancer / January 2006

Tip: Looking for answers? Try searching our database.

Dutch treatment

Thread view: 
Enable EMail Alerts  Start New Thread
Thread rating: 
alphatango@gamebox.net - 21 Jan 2006 13:47 GMT
Hi All

I've been looking up on Ovarian cancer and came across this article

http://news.bbc.co.uk/1/hi/health/1781840.stm

Dated Jan 2002

anyone know what happened to this form of treatment in the last 4
years? (Results, studies etc)

Thanks
J - 22 Jan 2006 01:31 GMT
> I've been looking up on Ovarian cancer and came across this article
>
[quoted text clipped - 4 lines]
> anyone know what happened to this form of treatment in the last 4
> years? (Results, studies etc)

cisplatin and etoposide? for ovarian cancer.
Looks like it's used for germ cell ovarian cancer at the cancer treatment
center (link below).
i don't know if this answers your questions, since you haven't really
explained why you are asking or where you live (if that's a problem
getting this treatment).
If I type BEP and ovarian into a search engine, I seem to get mostly germ
cell cancer type articles.
Let us know.
J
http://www.swedish.org/13693.cfm
Platinum Related Drugs
Common names include:

   * Cisplatin (Platinol-AQ)
   * Carboplatin (Paraplatin)

Cisplatin is used alone for certain ovarian cancers and in combination
with either cyclophosphamide or paclitaxel to treat advanced disease.
Cisplatin is also the third member of the standard BEP regimen for germ
cell cancers. Carboplatin is being tested as a substitute for cisplatin in
this combination, due to its lower toxicity. Carboplatin has been shown to
be as effective as cisplatin for epithelial ovarian cancer.

Possible side effects of platinum drugs include:

   * Life-threatening allergic reactions (rare)
   * Kidney damage (occurs only with cisplatin)
   * Hearing loss (most frequent with cisplatin)
   * Bone marrow damage
   * Liver damage
   * Nerve damage (most frequent with cisplatin)
   * Blood vessel damage

Epipodophyllotoxin
Common name: Etoposide
The second member of BEP treatment for germ cell cancers,
epipodophyllotoxin may be given on days 1 through 5 of each 21-day cycle.

Possible side effects of epipodophyllotoxin include:

   * Severe bone marrow suppression (low blood counts)
   * Severe allergic reactions
   * Nausea
   * Vomiting
   * Hair loss
alphatango@gamebox.net - 22 Jan 2006 02:51 GMT
Thank you for replying.

My family member has OV cancer which has recurred after treatment (new
tumor found, marker levels up again)

so i've been searching around the net for information and came across
this article. I do realise that logically, if this particular form of
treatment is really as good as it claims, it would be widely used today
since its been 4 years since its been found, and no one seems to have
heard about it...........

We live in Singapore, and she's been recieving treatment at our
National Cancer Centre.  But if there is a more  promising treatment
elsewhere we will travel.
Caveman - 26 Jan 2006 04:33 GMT
About the study I found on cisplatin and etoposide, I managed to contact the
dutch doc who conducted the study and this was all he could tell me

begin quote

>> today patients mostly receive upfront therapy with carboplatin and
>> taxol.
[quoted text clipped - 11 lines]
>> more.
>> Kind regards, R de Wit.

end quote

he refused to communicate further other than tell me to talk to my mom's
doctor.

can u tell me what u make of this weird message?

> > http://news.bbc.co.uk/1/hi/health/1781840.stm

> cisplatin and etoposide? for ovarian cancer.
> Looks like it's used for germ cell ovarian cancer at the cancer treatment
[quoted text clipped - 42 lines]
>     * Vomiting
>     * Hair loss
J - 26 Jan 2006 09:38 GMT
> About the study I found on cisplatin and etoposide, I managed to contact the
> dutch doc who conducted the study and this was all he could tell me
[quoted text clipped - 23 lines]
>
> can u tell me what u make of this weird message?

Looks to me that he's saying
"It is difficult to administer the dose dense weekly cisplatin (second line)
regimen plus semicontinuous oral etoposide (Dutch study), after 6 of these taxol
based cycles (first line carboplatin and taxol), because of cumulative
myelotoxicity.
Weekly cisplatin is not frequently used anymore.
Now, most patients receive carboplatin and taxol, as a first line treatment."

In other words:
it seemed like a good idea, at the time, but after the second line treatments,
they realized the first line treatment, was too toxic. (is my understanding of
what he's saying)

Maybe best to have your mom's doctor explain it or see if Steph agrees with my
interpretation.
J
 
Sign In
Join
My Latest Posts
My Monitored Threads
My Blog
My Photo Gallery
My Profile
My Homepage

Start New Thread
Enable EMail Alerts
Rate this Thread



©2008 Advenet LLC   Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.