My wife's last chest ct showed Lymphangitic Carcinamatosis. I have read
a few articles about this, but do any of you have any experience with
it? She is on FOLFOX with avastin. Is there any new study info to show
how well it responds to this regimen?
Debbie is 44 and has stage IV colon cancer (mets liver, lungs, retro
peritoneal, pelvis) that was diagnosed 11th of April '05.
The cancer was found after a hysterectomy that was done on the 8th
(pathologist found mets on the uterus)
a hemi-collectomy (resection) was performed on 4-15, chemo started on
5-15.
She is now on a two week Folfox regiment.
Thanks,
Mike
Steph - 15 Jan 2006 19:34 GMT
> My wife's last chest ct showed Lymphangitic Carcinamatosis. I have read
> a few articles about this, but do any of you have any experience with
[quoted text clipped - 10 lines]
> Thanks,
> Mike
The response rate is about 50%
The complete response rate is maybe 1%
It is very likely to make her feel better if she has lung symptoms though.
J - 15 Jan 2006 22:26 GMT
> My wife's last chest ct showed Lymphangitic Carcinamatosis. I have read
> a few articles about this, but do any of you have any experience with
[quoted text clipped - 8 lines]
> 5-15.
> She is now on a two week Folfox regiment.
Well, I don't know where "turtletrot" is but she blamed the avastin on her
husband's bowel perforration and told us that a trial with same for breast
cancer was stopped early for same reason.
He was on Folfox 7, but I don't know enough about these regimens to do
comparisons to another.
He also died of heart failure, he was older but I'm pretty sure she said
his heart was checked before start of treatment and checked out okay and
considered to be very fit for his age. I guess she'd have to tell you in
what way it was checked, if she's around. I think he had other lines of
treatment before and she'd have to tell you how far in to the Folfox 7 thse
complications occurred.
This web page says 28 days after surgery. You've cut it very close there.
Consider yourselves duly warned.
http://www.cancer.org/docroot/CDG/content/CDG_bevacizumab.asp
Also includes the heart warning.
"The drug may also, rarely, cause wounds that have healed to open up
(dehiscence)."
and since breast cancer patients haven't had colon surgeries (well, I
really don't know, so we'd have to hear from turtletrot), I have to wonder
how/why the heck they had bowel perforations.....
it's not my place to convince you to not be on chemo, but seems to me (a
layperson), where cure is unlikely it's better to treat to symptoms, rather
than risk complications.
Let's see if "turtletrot" has found more info about the breast cancer trial
and responds here.
Maybe the heart failure was the cumulative effect of long term various
lines of treatment because that web page mentions radiation to left chest
area, which he did not have, but possibly was previously on
anthracyclines. Joe mentioned high BP with avastin.
You might want to ask her doctor what the early warning signs are for bowel
perforations (unless they go in for a second look, along the way?), then
you'd know when to stop?
I may have posted trial results on sci.med.diseases.cancer, you'd have to
search through the archives.
Best wishes, keep in touch.
J - hate to be bearer of bad news, but think experiences should be shared.
(good or bad). Also check www.acor.org mail lists colorectal group