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Medical Forum / Diseases and Disorders / Cancer / November 2005

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Temozolomide (Temodar)

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J - 24 Nov 2005 00:43 GMT
I just noticed this, in case it helps anyone out there,
J

http://virtualtrials.com/temodar/
Last Updated:11/1/2005 (Update to the Temodar Review )

Click HERE to go to TEMODAR.COM which is the 'official' Temodar site -
developed by Schering Plough.

   * FDA Approves Temodar for use on patients with newly diagnosed
Glioblastomas!
   * Temodar package insert - changed 3/2005 to reflect dosages for use
during radiation (It is in PDF format. If you can't read it, install the
free adobe acrobat reader.)
   * Update to the Temodar Review - recent papers and abstracts on
Temodar THIS IS A MUST READ for everyone taking Temodar. It talks about
using Temodar at the same times as radiation, and using Celebrex
(celecoxib) with radiation! Print those 2 out and bring them to your
doctot!
   * Patient Instruction Sheet For Temodar.
   * Subscribe (free!) to the Temodar Mailing List!
   * Temodar Review - A review of the research on Temodar for brain
tumors.
   * Dosage Calculator

Medicare Approves Temodar for Reimbursement! As of May, 1999. Note: Most
pharmacies have no idea that it is covered. Ask them first, and if they
say it isn't, try other pharmacies. Some of the mail order places can
process it also.

Temodar is now available by prescription in the USA! (Check below for it's
availability in other countries!
If your pharmacy can't get it, One place to get Temodar in the USA is from
Biologics, Inc.
They will deliver anywhere in the USA. Call 1-800-850-4306 .

If you are having trouble paying for the drug, Schering Corp. has a
program called "Commitment to Care". This is a patient assistance program
(helps with reimbursement and if no reimbursement options are available,
patients are assessed for eligibility in cost share and free drug
programs). Call them toll free at: (see web page)
maryanne kehoe - 25 Nov 2005 06:04 GMT
I was under the impression Temodar has been approved since March of this
year (?)
J - 25 Nov 2005 10:36 GMT
> I was under the impression Temodar has been approved since March of this
> year (?)

It was approved by the FDA in March for maintenance therapy, after
radiotherapy for GBM .
The new approval of Temodar for GBM was based on efficacy and safety data
from a large randomized controlled study conducted by the European
Organization for Research and Treatment of Cancer (EORTC) in patients with
newly diagnosed GBM.
Temodar was previously granted accelerated approval in 1999 for the
treatment of adult patients with another form of brain tumor.

And before that (back to 1990) looks to me that it was available by
injection.
Temodar (temozolomide) is basically an orally-active form of dacarbazine.
Temozolomide is structurally related to dacarbazine  An anolog of
dacarbazine  (the www says)

So it looks like Temozolomide is easier to administer (by pill) and less
toxic.
Now it looks like they're testing (clinical trial) one vs the other for
Stage IV melanoma.
J
 
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