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Medical Forum / Diseases and Disorders / Cancer / April 2005Iron enriched diet / Colitis /colorectal tumors
Dig Dis Sci. 2005 Apr;50(4):696-707. Related Articles, Links Systemic iron supplementation replenishes iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: comparison with iron-enriched diet. Seril DN, Liao J, Yang CS, Yang GY. Susan L Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA. Ulcerative colitis (UC) patients frequently require iron supplementation to remedy anemia. The impact of systemic iron supplementation (intraperitoneal injection) on UC-associated carcinogenesis was assessed in mice subjected to cyclic dextran sulfate sodium (DSS) treatment and compared with dietary iron enrichment. Systemic iron supplementation, but not a twofold iron diet, remedied iron deficiency as indicated by the histochemical detection of splenic iron stores. A twofold iron diet, but not systemic iron, increased iron accumulation in colonic luminal contents, at the colonic mucosal surface, and in superficial epithelial cells. Colitis-associated colorectal tumor incidence after 15 DSS cycles was not affected by systemic iron (2/28; 7.1%) compared to nonsupplemented controls (4/28; 14.1%) but was significantly increased by the twofold iron diet (24/33; 72.7%) (P < 0.001). Mechanistic study revealed that systemic iron had no effect on DSS-induced inflammation, or colonic iNOS and COX-2 protein levels, compared to controls. Systemic iron supplementation for 16 weeks replenished splenic iron in a spontaneous colitis model (interleukin-2-deficient mice) and significantly reduced colonic inflammation compared to interleukin-2 (-/-) controls without increasing hyperplastic lesions. These results suggest that iron supplemented systemically could be used to remedy anemia in UC patients without exacerbating inflammation or enhancing colon cancer risk. These findings need to be verified in clinical studies. PMID: 15844705 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Interesting......my understanding is that iron supplementation is not the way to go. So many people have become sick. Why not just eat balanced diet? > Interesting......my understanding is that iron supplementation is not > the way to go. So many people have become sick. Why not just eat > balanced diet? Subject: Re: Iron enriched diet / Colitis /colorectal tumors Date: 23 Apr 2005 15:39:16 -0700 From: "J" <burglar_of_turds@yahoo.com> Organization: http://groups.google.com Newsgroups: alt.support.crohns-colitis,sci.med,sci.med.diseases.cancer,alt.support.cancer,sci.med.nutrition <snip> > Interesting......my understanding is that iron supplementation is not > the way to go. So many people have become sick. Why not just eat > balanced diet? They can eat anything they want but the problem is the colitis that renders absorption less than optimal. High concentrations are needed to gain not only a positive balance but to get rid of the deficiency in iron. So when one thinks and KNOWS that iron from meat .. BINDS .. to .. ALL other iron .. and it TOO .. now .. is INCREASED .. fourfold .. in absorption .. then what YOU .. might .. THINK is a 'balanced diet' .. is in TRUTH .. a diet which is VERY .. high .. IN .. iron .. So a normal diet .. meat based .. would .. according to the study .. BE.. the 'equivalent' .. OF .. "a twofoldirondiet" .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > [...] > is in TRUTH .. a diet which is VERY .. high .. IN .. iron .. [...] Is there a PMID about doubledot diseases? J J <esprit@anon.inv> wrote in part: >> [...] >> is in TRUTH .. a diet which is VERY .. high .. IN .. iron .. > >[...] Is there a PMID about doubledot diseases? >J Ironjustice used to write the National Weather Service bulletins. -- Jim Chinnis Warrenton, Virginia, USA |
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