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Medical Forum / Diseases and Disorders / Cancer / April 2005

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ZADAXIN

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Ryan - 09 Apr 2005 13:06 GMT
My Dad is going to have a surgery for liver cancer, and doctors suggest
ZADAXIN to help recovery.  Besides the injection drug, is there an oral form
with thymosin alpha 1 as primary ingredients can be found anywhere (GNC,
Walmart, etc)? Thanks a lot!
J - 16 Apr 2005 11:31 GMT
> My Dad is going to have a surgery for liver cancer, and doctors suggest
> ZADAXIN to help recovery.  Besides the injection drug, is there an oral form
> with thymosin alpha 1 as primary ingredients can be found anywhere (GNC,
> Walmart, etc)? Thanks a lot!

Sounds experimental and expensive, Rob.
I think (after I saw your post), I looked it up at www.rxlist.com and it's only
injection.
How's it going?
J
Ryan - 26 Apr 2005 16:02 GMT
>> My Dad is going to have a surgery for liver cancer, and doctors suggest
>> ZADAXIN to help recovery.  Besides the injection drug, is there an oral
[quoted text clipped - 8 lines]
> How's it going?
> J

Thanks for caring.  The surgery looks good so far, and he is recovering
well.
J - 26 Apr 2005 20:27 GMT
> "J" <ware@anon.anon> wrote in message
>
[quoted text clipped - 6 lines]
> Thanks for caring.  The surgery looks good so far, and he is recovering
> well.

Hello Ryan,
I'm pleased to read that your Dad is recovering well.  Primary liver cancer is
hard to stop.
http://www.rxlist.com/cgi/generic/zadaxin_ids.htm for ZADAXIN thymosin alpha 1
(thymalfasin) shows that it's for hepatitis? along with interferon.

Later, when he's fully recovered, you and he may wish to ask about clinical
trials (or ask later, if more cancer starts showing up).
I found one;it's in combo with chemoembolization and one of the criteria is
inoperable.
Biopsy/pathology is required.
http://clinicaltrials.gov/ct/show/NCT00082082?order=1
It's Phase II trial which measures for efficacy and toxicity.  As best I can
tell from another patient, chemoembolization can be as hard on the body as
surgery.  What is your Dad's age, please?

I suppose you could search yourself with the word HCC and then with the word
liver: Carcinoma, Hepatocellular
This is what I use to search.
http://clinicaltrials.gov/ or use "Studies by Condition"
The goal and objectives are usually mentioned for each trial.
Actually, I selected alphabetical "liver neoplasms".  There's 55 listed there.
Of course, it may be easier to just ask his oncologist, at that time.

In the meantime, I wish you both well. Keep in touch and let us know how's it
going.
J
Ryan - 28 Apr 2005 08:12 GMT
J.

    Thank you for the comprehensive information, that'll be enough for me
to digest in the next couple of weeks.  By the way, nothing urgent, but are
you familiar with liver transplant? Since my Dad had gone through two
surgeries on his liver, I guess the next time (couple of years from now)
would have to be a transplantation.  Will I be able to give half of my liver
to him?

Ryan

>> "J" <ware@anon.anon> wrote in message
>>
[quoted text clipped - 45 lines]
> going.
> J
J - 28 Apr 2005 10:20 GMT
>      Thank you for the comprehensive information, that'll be enough for me
> to digest in the next couple of weeks.  By the way, nothing urgent, but are
> you familiar with liver transplant? Since my Dad had gone through two
> surgeries on his liver, I guess the next time (couple of years from now)
> would have to be a transplantation.  Will I be able to give half of my liver
> to him?

Wait a sec, Ryan...seems to me the choices are:
clinical trial now.
wait for (visible) recurrence and decide
(one might exclude the other) a) clinical trial b) more surgery - removal of
more cancer or transplant.
or
c) palliative

Age and his fitness and quality of life, now or then, will be a consideration in
the decision-making process.
Location of the recurrence.
Also your age and fitness would be a consideration in a transplant decision. - I
don't know all the criteria for that.
It can't possibly be half your liver because of the vascularization in the
liver.
J-not an expert
J - 30 Apr 2005 09:01 GMT
>      Thank you for the comprehensive information, that'll be enough for me
> to digest in the next couple of weeks.  By the way, nothing urgent, but are
> you familiar with liver transplant? Since my Dad had gone through two
> surgeries on his liver, I guess the next time (couple of years from now)
> would have to be a transplantation.  Will I be able to give half of my liver
> to him?

Hello Ryan,
Peter says that liver transplant is not an option. Perhaps he would remind us
why..

J
 
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