Below you will see the effects of NOT limiting the amount of iron
available TO .. leukemia.

It is NOT .. good ..

Blood. 2001 May 1;97(9):2863-71. Related Articles, Links

Repression of ferritin expression increases the labile iron pool,
oxidative stress, and short-term growth of human erythroleukemia cells.

Kakhlon O, Gruenbaum Y, Cabantchik ZI.

Department of Biological Chemistry, Institute of Life Sciences, Hebrew
University, Jerusalem, Israel.

The role of ferritin expression on the labile iron pool of cells and
its implications for the control of cell proliferation were assessed.
Antisense oligodeoxynucleotides were used as tools for modulating the
expression of heavy and light ferritin subunits of K562 cells. mRNA and
protein levels of each subunit were markedly reduced by 2-day treatment
with antisense probes against the respective subunit. Although the
combined action of antisense probes against both subunits reduced their
protein expression, antisense repression of one subunit led to an
increased protein expression of the other. Antisense treatment led to a
rise in the steady-state labile iron pool, a rise in the production of
reactive oxygen species after pro-oxidative challenges and in protein
oxidation, and the down-regulation of transferrin receptors. When
compared to the repression of individual subunits, co-repression of
each subunit evoked a more than additive increase in the labile iron
pool and the extent of protein oxidation. These treatments had no
detectable effects on the long-term growth of cells. However,
repression of ferritin synthesis facilitated the renewal of growth and
the proliferation of cells pre-arrested at the G(1)/S phase. Renewed
cell growth was significantly less dependent on external iron supply
when ferritin synthesis was repressed and its degradation inhibited by
lysosomal antiproteases. This study provides experimental evidence that
links the effect of ferritin repression on growth stimulation to the
expansion of the labile iron pool.

PMID: 11313282 [PubMed - indexed for MEDLINE]

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http://www.cancerbacup.org.uk/QAs/LeukaemiaacutemyeloidQAs/GeneralQAs/General/re
lated_faqs/QAs/1141

Erythroleukaemia, AML M6, is mainly a disease of adults and makes up about I in
every 20 cases of AML. M6 may appear out of the blue but often it may develop
from a previous bone marrow problem such as myelodysplasia.

Treatments for these different groups of AML, except M3, are the same.
M0, M6 and M7 tend to have a poorer outcome and M2 and M4 tend to have a better
outcome.<end copied text>

You can connect with others with AML by subscribing to the private ACOR lists
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