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Medical Forum / Diseases and Disorders / Cancer / April 2005

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liver cancer 5 years, surgery or terasphere?

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Ryan - 24 Mar 2005 16:38 GMT
Hi, I just found this group 5 minutes ago and was encouraged by the kind
help people are offering here.

My Dad was diagonised of liver cancer 5 years ago.  He went through 2
surgeries in 2000 to remove the tumor in his liver, and one on his spine.
Doctors believe the one on the liver is the primary.  After that, he has
been doing well (with treatments every 4 months or so).

Recently, his AFP (Alpha-Feta Protein) raised suddenly to 2000 (I am not
sure about the figure, but <20 is considering good), and stopped responding
to treatments.  A PET/CT revealed that there's a 3cm x 4cm tumor on the
right liver,  After that, a high-resolution ultrasonic scan shows several
1cm thing in the same area.  The doctors are relunctant to do a second
surgery.  We are considering the terasphere.  Which one is the better
approach? Thanks for any help!
Steph - 24 Mar 2005 17:04 GMT
> Hi, I just found this group 5 minutes ago and was encouraged by the kind
> help people are offering here.
[quoted text clipped - 11 lines]
> do a second surgery.  We are considering the terasphere.  Which one is the
> better approach? Thanks for any help!

What are you hoping to achieve? That's the first question which needs to be
asked.
Ryan - 24 Mar 2005 17:07 GMT
>> Hi, I just found this group 5 minutes ago and was encouraged by the kind
>> help people are offering here.
[quoted text clipped - 14 lines]
> What are you hoping to achieve? That's the first question which needs to
> be asked.
We hope we can get another 5 years of quality life, and see how medicine
advances by that time.
Steph - 25 Mar 2005 03:01 GMT
>>> Hi, I just found this group 5 minutes ago and was encouraged by the kind
>>> help people are offering here.
[quoted text clipped - 16 lines]
> We hope we can get another 5 years of quality life, and see how medicine
> advances by that time.

I don't know of any evidence to suggest teraspheres can achieve that
Ryan - 25 Mar 2005 03:36 GMT
>> We hope we can get another 5 years of quality life, and see how medicine
>> advances by that time.
>
> I don't know of any evidence to suggest teraspheres can achieve that
Any journal paper on the effectiveness of the teraspheres on liver cancer?
thanks.
Ryan - 25 Mar 2005 18:20 GMT
Are there any new drug or treatment promising for liver cancer? Thanks!

>>>> Hi, I just found this group 5 minutes ago and was encouraged by the
>>>> kind help people are offering here.
[quoted text clipped - 18 lines]
>
> I don't know of any evidence to suggest teraspheres can achieve that
Steph - 25 Mar 2005 18:54 GMT
> Are there any new drug or treatment promising for liver cancer? Thanks!

Nothing new.
Ryan - 25 Mar 2005 22:18 GMT
How reliable is PET/CT in terms of revealing the tumors?
Is it safe to say (even if not 100% safe), places not shown on PET are
cancer free?

> Hi, I just found this group 5 minutes ago and was encouraged by the kind
> help people are offering here.
[quoted text clipped - 11 lines]
> do a second surgery.  We are considering the terasphere.  Which one is the
> better approach? Thanks for any help!
Steph - 26 Mar 2005 00:10 GMT
> How reliable is PET/CT in terms of revealing the tumors?
> Is it safe to say (even if not 100% safe), places not shown on PET are
> cancer free?

PET isn't perfect by any means, so no
J - 03 Apr 2005 19:29 GMT
> Hi, I just found this group 5 minutes ago and was encouraged by the kind
> help people are offering here.
[quoted text clipped - 11 lines]
> surgery.  We are considering the terasphere.  Which one is the better
> approach? Thanks for any help!

Hello Ryan and welcome to alt.support.cancer.
Sorry I'm late. My computer quit on me a week or so before your post.
Holden was looking into Theraspheres (SirSphires yttrium-90 ) a year ago.
We haven't heard from him since January of this year (I might do a roll call).
I think his were mets from colon to the liver. I just found his last post (in
the archives) and he was mostly on/off a combo of chemo.
He might be found at http://www.acor.org Mailing list, but I'm not sure which
list or you could try the liver cancer list.
Assuming your father has primary liver cancer (not mets, and not fibrolamellar
variant - apparently a slower growing liver cancer), your father has done quite
well.
Seems to me that Therasphere (radiated beads?) inserted in or near the liver
tumour(s) is also a surgery of sorts.
I know from what Dash's husband went through - fibromallar variant and
chemoembolization, it was pretty well a year of recovery from the treatment,
but hopefully if I do a roll call she and Holden will check in and update us
(and correct me if applicable). He was probably younger than your Dad and this
was his first ever surgery (as far as I know)

Are you the other Ryan (in "Progress in Liver Cancer treatment")?  If not,
perhaps one of you would pick and use a signautre line, so we can distinguish
between you two.

We haven't heard back from those who've had the procedure or inquired about (on
either of two cancer newsgroups) which makes me wonder why not...

I've had difficulty in the past finding the risks of such.  Seems so easy the
way some web pages describe it.
This is the best I've found on a quick search.
http://www.uab.edu/pbc/therasphere.htm
Apparently part of the dose can get into the lungs, stomach or intestine.
Other complications and procedures are described there.
Then what we also don't hear, is whether other tumours pop up in other areas of
the liver or how many people actually survive such a procedure or whether it's
mostly effective (success) for a very young, healthy subset of patients.

It's impossible for us to get a "picture" of your Dad. Some are old and frail,
some are younger and frail, some are middle-age but have been through a lot and
their organs cannot tolerate much more (surgery/chemo/radiation therapy of one
kind or another.  Then there's symptoms. I would want to know what symptoms my
loved one has, how they can best be addressed and how this treatment would
improve such, versus what troubles it might cause. I never want to encourage
someone to have a treatment that might kill their loved one in the process of
trying for a cure or making a tumour shrink or disappear.  Hope you understand
where I'm coming from?

Keep in touch and let us know how you and your father are doing and what the
decisions are/will be.
We'll be here for you, as best we can
J
Ryan - 03 Apr 2005 23:35 GMT
>> Hi, I just found this group 5 minutes ago and was encouraged by the kind
>> help people are offering here.
[quoted text clipped - 14 lines]
>
> Hello Ryan and welcome to alt.support.cancer.

Thank you J.  After reading some materials available online it looks not
good.
Most papers about teraspheres treatment were about its impact on health,
rather than it's effectiveness in treating cancer.  The impression is that
it's
a alternative way of traditional chemotherapy, only with reduced side
effect.
However, the traditional chemotherapy has been seen as 'something to do
when there's nothing else can be done'.

> Sorry I'm late. My computer quit on me a week or so before your post.
> Holden was looking into Theraspheres (SirSphires yttrium-90 ) a year ago.
[quoted text clipped - 27 lines]
> distinguish
> between you two.

It's the same.;-)

> We haven't heard back from those who've had the procedure or inquired
> about (on
[quoted text clipped - 33 lines]
> the
> decisions are/will be.

He will go through a surgery removel of within 24 hours.

> We'll be here for you, as best we can
> J
J - 04 Apr 2005 08:29 GMT
> "J" <banish@anon.inv> wrote in message
>
[quoted text clipped - 12 lines]
> However, the traditional chemotherapy has been seen as 'something to do
> when there's nothing else can be done'.

My impression is that theraspheres is an alternative and targeted way to deliver
radiation therapy and that chemoembolization is an alternative targeted way of
delivering chemo.
My impression is that both are effective on treating known tumours, but not
systemic treatment.
Isn't it strange on how we get different impressions. Steph???

> > Are you the other Ryan (in "Progress in Liver Cancer treatment")?  If not,
> > perhaps one of you would pick and use a signautre line, so we can
> > distinguish
> > between you two.
>
> It's the same.;-)

Thanks for clarifying, Ryan.

> [...]
> > Keep in touch and let us know how you and your father are doing and what the
>
> > decisions are/will be.
>
> He will go through a surgery removel of within 24 hours.

All my best for a good outcome and a complete recovery.
J
Steph - 04 Apr 2005 16:55 GMT
>> "J" <banish@anon.inv> wrote in message
>>
[quoted text clipped - 27 lines]
> systemic treatment.
> Isn't it strange on how we get different impressions. Steph???

They can both produce responses. Whether the responses mean anything useful
is another issue......

>> > Are you the other Ryan (in "Progress in Liver Cancer treatment")?  If
>> > not,
[quoted text clipped - 16 lines]
> All my best for a good outcome and a complete recovery.
> J
 
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