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Medical Forum / Diseases and Disorders / Cancer / February 2005Vitamin C / Iron / melanoma
J Cell Physiol. 2005 Jan 25; [Epub ahead of print] Links Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake. Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. Sodium ascorbate (vitamin C) has a reputation for inconsistent effects upon malignant tumor cells, which vary from growth stimulation to apoptosis induction. Melanoma cells were found to be more susceptible to vitamin C toxicity than any other tumor cells. The present study has shown that sodium ascorbate decreases cellular iron uptake by melanoma cells in a dose- and time-dependent fashion, indicating that intracellular iron levels may be a critical factor in sodium ascorbate-induced apoptosis. Indeed, sodium ascorbate-induced apoptosis is enhanced by the iron chelator, desferrioxamine (DFO) while it is inhibited by the iron donor, ferric ammonium citrate (FAC). Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate. Cells exposed to sodium ascorbate demonstrated down-regulation of TfR expression and this precedes sodium ascorbate-induced apoptosis. Taken together, sodium ascorbate-mediated apoptosis appears to be initiated by a reduction of TfR expression, resulting in a down-regulation of iron uptake followed by an induction of apoptosis. This study demonstrates the specific mechanism of sodium ascorbate-induced apoptosis and these findings support future clinical trial of sodium ascorbate in the prevention of human melanoma relapse. (c) 2005 Wiley-Liss, Inc. PMID: 15672419 [PubMed - as supplied by publisher] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > J Cell Physiol. 2005 Jan 25; [Epub ahead of print] Links ---------- Forwarded message ---------- From: ironjustice@aol.com Date: 17 Jan 2005 15:11:02 -0800 Subject: Re: Liver steatosis /serum iron / transferrin saturation / ferritin To: Now .. john .. when markd .. attacks me .. it is the 'frog' .. humping .. me ..eh .. So what does that mean .. YOU .. do ..? Eh .. pussssiiiieeee .. Eh .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Heh .. heh .. Look .. into .. it .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking During congressional hearings (back in the 1960s) the president of the AMA admitted that the Hoxsey external treatment did cure cancer; Shortly after he was fired from his post. > During congressional hearings (back in the 1960s) the president of the > AMA admitted that the Hoxsey external treatment did cure cancer; Shortly > after he was fired from his post. /yawn same old stuff. J I hope EVERYONE .. realizes the .. significance of .. 'J's .. response. The study specifically speaks to the finding of vitamin C halting .. melanoma .. a theory spoken to for many years .. and what IS .. the response by .. 'J' .. ? Exactly WHAT .. 'good' .. IS she on this newsgroup .. ? To defer people AWAY from .. viable .. treatments with her .. stupidity .. ? Better watch who you listen to .. it could mean your .. death .. IMHO .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > I hope EVERYONE .. realizes the .. significance of .. 'J's .. response. I certainly do! Someone has to point out your stupidity. Tom, you have been trolling Usenet for about 10 years now with the same old lame theory about iron, meat, and the bible. Here is a small sample of your trolling http://groups-beta.google.com/groups?q=ironjustice&hl=en&lr=&sa=N&tab=wg I don't care if you paste that crap for 100+ years it is still idiotic nonsense and nobody will believe it. All you are accomplishing is filling some hard drives with useless data at a Google server farm. Jerry So .. Jerry .. keeping yourself .. busy .. are ya .. A replay of the original article which began this thread should be appropriate .. J Cell Physiol. 2005 Jan 25; [Epub ahead of print] Links Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake. Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. Sodium ascorbate (vitamin C) has a reputation for inconsistent effects upon malignant tumor cells, which vary from growth stimulation to apoptosis induction. Melanoma cells were found to be more susceptible to vitamin C toxicity than any other tumor cells. The present study has shown that sodium ascorbate decreases cellular iron uptake by melanoma cells in a dose- and time-dependent fashion, indicating that intracellular iron levels may be a critical factor in sodium ascorbate-induced apoptosis. Indeed, sodium ascorbate-induced apoptosis is enhanced by the iron chelator, desferrioxamine (DFO) while it is inhibited by the iron donor, ferric ammonium citrate (FAC). Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate. Cells exposed to sodium ascorbate demonstrated down-regulation of TfR expression and this precedes sodium ascorbate-induced apoptosis. Taken together, sodium ascorbate-mediated apoptosis appears to be initiated by a reduction of TfR expression, resulting in a down-regulation of iron uptake followed by an induction of apoptosis. This study demonstrates the specific mechanism of sodium ascorbate-induced apoptosis and these findings support future clinical trial of sodium ascorbate in the prevention of human melanoma relapse. (c) 2005 Wiley-Liss, Inc. PMID: 15672419 [PubMed - as supplied by publisher] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > So .. Jerry .. keeping yourself .. busy .. are ya .. Yes I am Mr. Troll, thank you. Reposting articles that suit your twisted idea of medical research does not prove your case. Just because you were born with two genetic defects does not mean that the rest of the world suffers the same inadequacies. Get yourself a good doctor and psychiatrist, as both of your problems are treatable. Jerry Jeez .. learning something .. already .. eh .. Jerry .. Cannot dispute the .. facts .. Attack .. the .. poster .. Eh .. WHAT .. you .. have .. 'learned' .. is HOW to be a .. pussy .. How does that .. feel .. Eh .. Heh .. heh .. Jeez .. maybe you can aspire to be an .. oncologist .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking So .. Jerry .. keeping yourself .. busy .. are ya .. A replay of the original article which began this thread should be appropriate .. J Cell Physiol. 2005 Jan 25; [Epub ahead of print] Links Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake. Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. Sodium ascorbate (vitamin C) has a reputation for inconsistent effects upon malignant tumor cells, which vary from growth stimulation to apoptosis induction. Melanoma cells were found to be more susceptible to vitamin C toxicity than any other tumor cells. The present study has shown that sodium ascorbate decreases cellular iron uptake by melanoma cells in a dose- and time-dependent fashion, indicating that intracellular iron levels may be a critical factor in sodium ascorbate-induced apoptosis. Indeed, sodium ascorbate-induced apoptosis is enhanced by the iron chelator, desferrioxamine (DFO) while it is inhibited by the iron donor, ferric ammonium citrate (FAC). Moreover, the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin, suggesting that transferrin receptor (TfR) dependent pathway of iron uptake may be regulated by sodium ascorbate. Cells exposed to sodium ascorbate demonstrated down-regulation of TfR expression and this precedes sodium ascorbate-induced apoptosis. Taken together, sodium ascorbate-mediated apoptosis appears to be initiated by a reduction of TfR expression, resulting in a down-regulation of iron uptake followed by an induction of apoptosis. This study demonstrates the specific mechanism of sodium ascorbate-induced apoptosis and these findings support future clinical trial of sodium ascorbate in the prevention of human melanoma relapse. (c) 2005 Wiley-Liss, Inc. PMID: 15672419 [PubMed - as supplied by publisher] ---------------------------------------------------------------------------- ---- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Took megadoses of vitamin C for over 20 years, still developed cancer, hmmmmm. >>Took magadoses of vitamin C for over 20 years<< vitamin C doesn't .. remove .. iron .. It suppresses it IF .. there is .. enough ascorbate and / or the iron is NOT .. overly .. abundant .. One notices the addition of deferoxamine .. ADDS to the .. killing ... Therefore one might surmise .. iron reduction .. to the POINT .. of .. the body itself BEING .. 'able' to sequester / bindup the iron .. itself .. might be worth the effort .. ? That would mean lowering the iron levels down to the level found in a normal person which would be the 'new hypothesis' .. of 25% transferrin saturation .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Iron in cancer .. BMC Cancer. 2004 Jan 15;4(1):1. Related Articles, Links Iron: a target for the management of Kaposi's sarcoma? Simonart T. Department of Dermatology, Erasme University Hospital, Route de Lennik 808, B-1070 Brussels, Belgium. tsimonar@ulb.ac.be BACKGROUND: Kaposi's sarcoma (KS) is a mesenchymal tumour associated with human herpesvirus-8 infection. However, the incidence of human herpesvirus-8 infection is far higher than the prevalence of KS, suggesting that viral infection per se is not sufficient for the development of malignancy and that one or more additional cofactors are required. DISCUSSION: Epidemiological data suggest that iron may be one of the cofactors involved in the pathogenesis of KS. Iron is a well-known carcinogen and may favour KS growth through several pathways. Based on the apoptotic and antiproliferative effect of iron chelation on KS cells, it is suggested that iron withdrawal strategies could be developed for the management of KS. Studies using potent iron chelators in suitable KS animal models are critical to evaluate whether iron deprivation may be a useful anti-KS strategy. SUMMARY: It is suggested that iron may be one of non-viral co-factors involved of KS pathogenesis and that iron withdrawal strategies might interfere with tumour growth in patients with KS. PMID: 14725718 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > From: "Susan" <now@nospam.inv> > Newsgroups: alt.support.cancer [quoted text clipped - 12 lines] > Path: uni-berlin.de!fu-berlin.de!newshub.sdsu.edu!cyclone.bc.net!news.alt.net!newsfeed.slurp.net!not-for-mail > Xref: uni-berlin.de alt.support.cancer:115513 Posting insane theories does not make them credible. In fact, it makes the poster appear insane. > <ironjustice@aol.com> wrote in message https://support.nuvox.net/index.php/999 > I hope EVERYONE .. realizes the .. significance of .. 'J's .. response. > [quoted text clipped - 3 lines] > > Exactly WHAT .. 'good' .. IS she on this newsgroup .. ? From the way J so readily uses multiple addresses to keep people from kill filing her, I suspect she also posts under various identites and sides with herself :o/ > From the way J so readily uses multiple addresses to keep people from > kill filing her, I suspect she also posts under various identites and > sides with herself :o/ I suspect she posts under various identities because of the trolls and lunatics that visit the newsgroups. You should be wondering why Tom (ironidiot) thinks fish and lamb are vegetables. Jerry From the way J so readily uses multiple addresses to keep people from >> kill filing her, I suspect she also posts under various identities and >> sides with herself :o/ > > I suspect she posts under various identities because of the trolls and > lunatics that visit the newsgroups. Jerry, How can changing one's address protect the poster? I assumed ( it seems incorrectly) re arranging one's address once does the job, should we all be changing our addresses? Thanks , Alex > should we all be changing our addresses? You did already, 3 times (at least) - your real email address, @guess.com, @then guesswho.com May I suggest that you quit asking "innocent" questions in order to try to obtain more information. It does not become you to be so transparent. J > You did already, 3 times (at least) - your real email address, @guess.com, > @then guesswho.com > May I suggest that you quit asking "innocent" questions in order to try to > obtain more information. > It does not become you to be so transparent. > J What is wrong is obtaining more information? I thought this was a support group and we are here to share, secondly, 3 addresses is nothing, I had dozens of yours in my outlook until it became unmanageable. So it should be easy for you to block my posts. Alex > From the way J so readily uses multiple addresses to keep people from >>> kill filing her, I suspect she also posts under various identities and [quoted text clipped - 7 lines] > incorrectly) re arranging one's address once does the job, should we all be > changing our addresses? Thanks , Alex Alex, It is never a good idea to post your real name and personal information on the Internet. It can be used by unscrupulous individuals to harass you. Some trolls and lunatics will post your email address all over the Internet if you disagree with them. They are also known to add you to spam lists or sign you up to porn subscriptions. They have also forged emails and posted to sexually explicit newsgroups using their targets address. This is intended to embarrass the target or get them in trouble with the law. I never use real information online. I also change my address when it appears that spammers have me on their lists. Look into aliases, they can be changed in a few minutes and do not require a call to your ISP. If that does not work look into a throw away email account from a free service like Hotmail. Change your address as often as needed. It is your call to decide how often that might be. Do not use your name in your email address, if that address will be posted on newsgroups. Also, if you need to post your email address, be sure to munge it or spam proof it. You can explain in the text how to make it usable. I hope that answers you question. Jerry > I never use real information online. I also change my address when it > appears that spammers have me on their lists. Look into aliases, they can [quoted text clipped - 15 lines] > > Jerry It does, I frequent many other non medical newsgroups, such as satellite radio, cell phones, etc, everyone there appears to be using their real email address. I feel almost rude posting a phony name, yet, I have to admit since I have stopped using my real email address here and the breast cancer support the amount of spam has decreased. Must be something related to the medical issues which make people think you are easy targets. Alex >>You should be wondering why Tom (ironidiot) thinks fish and lamb are vegetables. << I have .. NEVER .. said .. fish and lamb are .. vegetables .. WHERE did I say .. fish and lamb are .. vegetables ..? I would NEVER say .. fish and lamb are .. vegetables .. THAT would be blatantly .. stupid .. And .. I .. cowboy .. ain't .. stupid .. So .. you must have me mistaken for someone .. else .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > > From the way J so readily uses multiple addresses to keep people from > > kill filing her, I suspect she also posts under various identites and [quoted text clipped - 7 lines] > > Jerry hiya J > > Jerry > > hiya J Apparently can't read headers nor posts, eh? I'm in Canada, Jerry's somewhere in the US. J >>> From the way J so readily uses multiple addresses to keep people from >>> kill filing her, I suspect she also posts under various identites and [quoted text clipped - 9 lines] > > hiya J I think you have me confused with someone else. Maybe you should read this group for a while before posting more of your theories. Jerry > > From the way J so readily uses multiple addresses to keep people from > > kill filing her, I suspect she also posts under various identites and > > sides with herself :o/ > > I suspect she posts under various identities because of the trolls and > lunatics that visit the newsgroups. You might be talking to one. He's on the filters list. Hoxley post and Fasting book and general heckler on this newsgroup. Never (AFAIC) introduced himself. J > > > From the way J so readily uses multiple addresses to keep people from > > > kill filing her, I suspect she also posts under various identites and [quoted text clipped - 7 lines] > Never (AFAIC) introduced himself. > J How am I in your filter list if just 6 minutes before you posted this message you also responded directly to my other post in this thread?? and with the same exact identity?? > I suspect she posts under various identities because of the trolls and > lunatics that visit the newsgroups. One of the reasons I do it, is so people cannot filter me. My way has been to warn them first (before reporting them), about inappropriate posting. If they filter me, then they cannot see the warning. J |
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