NATURAL TREATMENTS
POISONS OF?DICOS IN THE TREATMENT OF THE CANCER

B. Cobraminol?tico: Solution Gal?nica Antitumoral

"the concentrated protoenzim?tico arsenal in the of?dico poison,
denominated Direct L?tico Factor technically, responds to digestive
necessities exclusively"

The poisons drive according to a "strategy" in which two different
although synchronous effects can be distinguished clearly: "the
curarizantes" tractions of the effect (neurotoxinas), that immobilizes the
prey, which is swallowed whole (not chewed nor salivada); and the
fractions of the poison of proteolytic effect, which have a specific
predilection by certain visceral weaves, depending this selectivity to the
sort to which ofidio belongs.

Although the chemical structure of poisons has an enzymatic composition
common, present in all of them, each of?dico sort has catalytic
concentrating that distinguishes them.

Thus for example, the Crotoxina is a polypeptide structure with a basic
component and another only present acid in the Crotalidae; which outside
defined chemically like L-Arginina ?sterhidrolasa (TAME: this one methylic
one of the toluensulfonil L-Arginina), Peptide-peptide hidrolasa (3.4.4)

The numbers indicate the number of order of the of?dicos biocatalizadores
in the Classification the International of the Enzyme Committee of the
Union the Biochemical International.

In the course in which doctor Calmette and doctor Guerin worked associate,
which among other advances even resulted in vaccine BCG, by
Calmette-Guer?n Bacillus, used in Melanomas, was developed a febrile
international investigation, initiated in fact to principle of century in
France, on chemistry, biochemistry and pharmacology of of?dicos poisons.

Although already in 1883 doctor Ameden used successful the poison of
Cr?talus to prevent the convulsions caused by the Tetanuz, was just until
1915 when the antielap?dico serum was standardized like "isof?nica
solution of the hyperimmunized equino animal globulins".

He was in the years 20 that doctors Vital Brazil and Monoelesser developed
exhaustive investigations on the action of the of?dico poison in the
treatment of the Leprosy.

The clinical conclusions, casuistry and the enzymatic segments used by
these investigators, Brazilian and North American respectively, were
communicated doctor Calmette who was excited by the full effects obtained
on lepers in Cuba.

By then Calmette already had finalized him clinical experimentation in
hundreds of patients, as much with the "fractions of Curarizante effect",
like with those of Selective Proteolytic effect of the poison of Elapidae
- Naja attenuated Tripudians- 1/100.000. Obtaining by a powerful side
analgesia without toxicity nor secundarismos, as well as remission in the
great majority of the patients with cancer, mainly in which they
presented/displayed carcinoma of ovary, intestine and prostate.

Monoelesser and Taguet summarize all the aspects of these investigations
in a communication that outside presented/displayed in the Medicine
Academy by illustrious professor Dr. Gassel the 14 of March of 1933.

The same Gassel 1? of April of 1933 presented/displayed the confirmation
of the capacity analgesic, discovered years before, experienced in more
than 1200 cases of patients with nonatenuables pains not even with
injectable morphine.

But the beginning of 2da. World war interrupted and darkened all these
efforts and advances; mainly so that some fractions of of?dicos poisons
became "strategic factors" like antidotes against the chemical and
bactereol?gica war. In addition to the irruption at the end of the war of
"panacoa" metil bis (2 cloroetil) amine (nitrogenadas mustards) and its
manifold variant in the treatment of the cancer.

In 50 years doctor Vital Brazil (son) next to doctor Avelino District
(eminent Argentine doctor), made important investigations on poison of
Cr?talus durissus terr?ficus discovering the Veratr?nicas properties of
these.

At the moment many deprived international laboratories make use of the
most valuable of?dica investigation, in the drug design for human use.

For this specific enzyme separation, of the total mosaic that constitutes
the poison, we did not use chemical reagent some, but a novel methodology
of automatically controlled emptiness and a rank of condensation that goes
of the room temperature to -20? C, separating selectively the looked for
enzymes.

The rank of purity of each of each fraction we identified it with
spectrometer equipped with a registry of aspects that registers above of
17000 active principles, although in some phases of the process we must
make use to the GCD - chromatography with mass spectrometry -.

Although all the saying until is secondary here in relation to the
high-priority thing, that means the sterility of the atmosphere in which
it is processed, as well as the temperature in the same one, our sterile
area works to controlled atmosphere, all the air happens through
activated-carbon filters, which maintains the atmosphere free of esporas,
they polen, steam of water and to 5? C, but even so the manipulations must
be made under Flow Laminate Horizontal.

These are, we say, single some of the salient aspects of the complex
methodology of elaboration.

ACTIVE PRINCIPLES OF OFIDEOS:

COBRA: Citol?tico, analgesic, regulating par excellence metabolic, because
fosfolipasas A2 of naja is a fraction purified in this case one naja, when
entering the organism "sticks" to the tumorlike cell very "loaded" this
one of phospholipids and it begins it to lisar of this form: it does not
touch any other affected cell.

BELL: Analgesic - Citol?tico, but of greater being able analgesic. It is
also a purified fraction chromatographically of Crotalus Durissus
Terrificus, happening to become one fosfolipasa A2 of crotalus.

INDICATIONS CLINICAS

ONCOLOG?A

Tumors of head and neck
Tumors of breast
Tumors of the urogenital apparatus (masculine and feminine)
Hematol?gicos tumors
Tumors of soft parts (Melanomas-Sarcomas-Cordomas, etc.)
Tumors of lung and esophagus
Tumors of the gastrointestinal apparatus
Tumors of skin

COLGENOPAT?AS

Sist?mico erythematous lupus
Reumatoidea arthritis
Progressive sist?mica sclerosis
Knotted Poliartritis
Anquilosante Espondilitis
Syndrome of Reiter
Psoriasica arthritis
Youthful reumatoidea arthritis

NEUROLOGICAL

Sclerosis in plate
Angioesclerosis or disease of Alzehimer
Idiop?tica acute Polineuritis
Progressive muscular atrophy

The Morning of the South - (regional Information of Neuquen and Ri'o
Negro.) EXTERNAL RECOGNITION FOR CROTOXINA; CREOLE POVERTY

PARANA. - The magazine Clinical Cancer Research, official organ of the
American College of Clinical Cancer Research of the United States, by the
end of published the results of a faced investigation the decade last in
Parana, over the effects of the crotoxina in the cure of the cancer. In
his conclusions it is specified almost that the drug demonstrated
statistically, in the 80 percent of the oncol?gicos patients treated
experimentally, a diminution or disappearance of the pains, and a greater
general well-being of the patients. Nevertheless, it was not possible here
to be followed with the investigation by the lack of resources.
The mentioned magazine put under the work of the Argentine scientists an
evaluation in which, due to the specificity of the subject, they also
participated like investigating consultants of the Research laboratory of
the General Massachussets Hospital of Boston (University of Harvard).
After a detailed analysis, the magazine decided to publish the work with
the title "Phase I and Pharmacokinetics Study of Crotoxin in Patients UIT
Advanced Cancer (vol. 8, 10033-1041), - Phase I. Farmacocin?tico Study of
the Crotoxina in Patients with Advanced Cancer granting thus international
recognition to him to the investigation developed in our country, that had
to be suspended by lack of resources.
The studies on the effects of the crotoxina, a mediation that some years
ago appeared as an alternative for the cure of the cancer, were made in
the hospital San Mart?n of Parana and were in charge of an equipment
directed by the technical associate of the Conicet and director of
Medicine the Educational Unit of Parana (UDAM), Jorge Cures.

THE STUDY OF THE POISON OF THE BELL SERPENT CAN LEAD DRUG ANTI-CANCER

Subject of study: The surprising molecular similarity of enzymes of the
poison of bell serpent and the cells of the human cancer can help
naturally to destroy the disease with new powerful drugs.

Batimastat, a manufactured experimental drug in England, was found to stop
the invasion of the cells. "Like putting a sticky tape in the mouth of a
lizard" according to the Dr Edgar Meyer, a biochemist of the Experimental
Department of Agriculture of Texas. The findings of the equipment of
investigation of Meyer are reported in the "April Proceedings of the
National Academy of Sciences". The work was a collaboration between the
University of Texas and the Dr Sends to Liotta of the laboratory of
pathologies of the National Cancer Institute de Betheseda, Md.

The previous observation of Meyer on the molecular structure of enzymes of
the bell poison, that is almost identical to the cell of human cancer, has
helped the finding of ways to block the extension of the cancer leaving
the search of new inhibitors.

"When the poison is injected the human who is pricked by a serpent the
fluid it penetrates around the weave to enter the blood" explained Meyer.
"In the same way the cell of the tumorlike met?stasis penetrates around
the membrane to enter the circulatory system".

It says that the maquillaje of enzymes of the poison differs but the
molecules have the same structure fundamentally that have the cancerous
cells. Its model constructed in 3? dimension with a program of special
computer shows to the structure with a mouth opened with a Zinc atom and a
water molecule in means. This present Zinc in both (cancerous cell and
poison of serpent) begins to destroy the healthy weave.

The scientific challenge has been to find a form to block the opening,
thus this way prepares the process from the beginning. "If You Want to
control the degenerative process, You Must go behind Zinc," said "" This
is the action mechanism ".

"This is a powerful chain that makes a first cut in a link. This is
debilitated and the hole can be made more and greater until the chain
becomes broken completely "Meyer added.
The biochemist noticed that the cancer is an extremely complex disease,
"but these are steps that they define that it happens and when. Soon You
See inhibitors that are good to stop this process ".

To understand this process was possible behind Dachuan Zhang, one of the
students graduated as Meyer, that found a way to let grow crystals of the
enzyme of the poison. This it gave to the equipment an atom puzzle him
that was located together in a molecular structure in 3? dimension within
a computer.

Using eyeglasses of 3? dimension in the laboratory of Meyer in the
University of Texas, the equipment can visualize "a unique cavity within
which the inhibitor has entered" as ring the finger ".

The investigation showed that Batimastat, deeply thus ties to the
structure, this way coming up that the poison or the cell of the tumor
begins their destructive work.

Meyer said that the hard enzymes of human cancer are available, the viper
poison enzyme was useful in this test because it is a very stable molecule
available and quickly susceptible to be cloneada easily.

A difference with the new experimental drug, said he, is that the present
methods of chemotherapy "poison" the body filling first by a fast growth
of the cancerous cells but causing indirect effect on the other side in
the healthy system of the body, Batimastat is an example of a new
developed drug generation to go direct to the problem and to close those
detrimental enzymes without affecting the others.

In experiments with humans the drug has been injected in a solid form,
which slowly goes within the solution, he said.

"This is another challenge (to administer the drug orally). This has
passed secretly the system digestive and circulatory to turn it the target
"Meyer it added.

It said that these new discoveries are promising, but some questions are
still without responding like doing that the process "to chew the healthy
cells" begins, and once the process begins how to make stop it.

The equipment has designed drugs of pending proposals with the U.S.
National Cancer Institute Cooperative Drug Discovery Group, said he.

STRUCTURE OF COMPLEX CROTOXINA

Jaap Brink and Wah chiu

Center W. M. Keck for Computerized Biology and the Department of
Biochemistry Verna and Marrs McLean, School Baylor de Medicina.

The Crotoxina complex is the main neurotoxina of the South American
serpent of bell, Crotalus durissus terrificus with a molecular weight of
24 kDa. The protein is to heterodimer of the subunits To and B, with the
subunit To assigned to a function of chaperone and the B drive that the
neurotoxic activity takes. This last activity is exerted in both sides of
the neuro-muscular functions. Still they lack to determine solely the
physiological and farmacol?gicos aspects of the protein for a structural
base. The crotoxina complex crystallizes easily in two dimensions (2D) and
thin crystals of three dimensions (3D) that are treatable in a
cristalogr?fico electronic study. Series Inclined with patterns of
electronic crystal diffraction absorbed in glucose of 128 ? of thickness
were reunited in 400 an electron microscope JEOL4000EX kV using a camera
CCD of scanned slow Gatan 679. This profit is useful because it
facilitates combined information of several crystals, which can be
difficult to obtain due to the variation of thickness between crystals, or
due to the lack of plain of crystals. The combination of 6 series inclined
with patterns of diffraction 353 was complimented with scale of PROTEIN
use and computerized factors of temperature from found reflections common
in any film game. The refinement of the direction of the patterns of
individual diffraction in the information game took place 3D combined by
variation of the azimuth and rakes using MERGEDIFF. The continuous
diffraction in z * of the information game 3D refined was fixed using a
function sinc with a wide one of 17196.A1 using SYNCFIT.
The game of intensity information combined 3D was included/understood by
55.000 reflections corresponding to 75% of 3,3 integrity and extended to ?
in hk0 and 4,2 the plane ? in direction z *. the total of Rmerg is 0,26
with a Rsym of 0.15. Some curves turned out to adjust enough good with a
Rmerg of 0.16, inasmuch as others combined poorly enough to Rmerg 0.45.
the analysis of individual inclined series revealed the absence of the
symmetry waited for in plane. These observations suggest a problem in the
packing of the crystals, that we hoped to direct negatively by means of
the processing of inclined series of colored complex crystal images of
crotoxina.

FEEDING

The pharmacy is in verduler?a

Prog. Cientifica and Tecnica de Fundacion Campomar

Source: Cancer Research Vol. 52,7 - April 1992
Cience Vol. 257 - September 1992

The investigations agree: as the grandmother said, the health begins in
the table.

For the specialists in nutrition, the nourishing habits of most of people
let so much wish, as far as the quality and composition of the diet, that
some have gotten to perhaps affirm - somewhat exaggerated that "the man
digs his tomb with his own teeth".
But, what has of the many foods that, on the contrary, they are beneficial
for the health?
For a long time studies have been known epidemiologists who demonstrate
the existence of a direct correlation between the habitual consumption of
determined vegetal and the diminution the risk of contracting certain
types of cancer.
However, recent scientific researches have been able to determine or the
active principles responsible for the anticancerigenic action of such, in
agreement with a report published in the magazine Cancer Research.

Green and healthy
The list of vegetables and fruits that conform the arsenal of "enemies of
the cancer" is as extensive as varied.
A place of privilege in the same one occupies vegetables pertaining to the
group of the cruc?feras. Among them we found to the coliflor, repollo and
br?coli. An equipment of investigators of the American Foundation for the
health, of New York, found that comjunto of known compounds as
organosulfurados - present in these vegetables they can inhibit the cancer
of laboratory animal colon, according to the Science magazine. This
finding has individual importance for the Americans, considering who such
disease represents the second cause of death by c?nceren the United
States.
The cruc?feras also could be effective to prevent the development with the
lung cancer, in individual in people smokers, in agreement with Fung-Lung
Chung, chemistry of the same foundation. One of the main people in charge
of the damages produced by the tobacco at pulmonary level is a group of
chemical substances - the nitrosaminas - of which most injurious is
well-known generically like NNK. The expert of Chinese origin found that a
set of compound - called isotiocianatos-, presents in the coliflor and its
relatives, they inhibit the production of the cancer of animal lung
exposed in experimental form to the NNK. Equal property demonstrates
certain extracts of citrus (D-limonenos); of vegetables of the family of
the lili?ceas - garlic, onion, puerro, ?chalotte- (also organosulfurados),
and of the plant of the tea.
For that they are not used to incorporating no of these vegetables in the
daily diet still is left the soybean sauce. Michael Pariza, an
investigator of the University of Wisconsin, discovered that this
condimento has the property to inhibit the cancer of laboratory animal
stomach. According to the scientist, the active principle responsible for
such action would be a well-known chemical substance by the experts like
HEMF. "Only one small portion of the pure extract of HEMF -25 parts by
million in the diet of the animals - it was sufficient to reduce to a 75%
the number of stomach tumors", affirms Pariza.

Moment of action
The specific mechanisms of anticancerigenic action of many of vegetables
are not still well included/understood by the specialists.
According to Lee Wattenberg, of the University of Minnesota, the contained
antitumorlike compounds in vegetables can be classified in three
categories, in agreement with the moment for exerting their activity. In
this sense, a first group is conformed by those substances that prevent
the development with a tumor inhibiting to precursory chemical compounds
of this process. Secondly are those that they prevent that the carcinogen
agents can arrive or react with the cells "white" of each corporal weave.
Finally they are those substances that act suppressing the tumorlike
growth of cells that previously have been exposed to carcinogen doses of
sufficient to develop the disease.
Beyond the determination of the reasons by which certain vegetables have
anticancerigenic properties, the nutricionistas experts recommend to
consume generous rations of vegetables and fruits with the daily diet.
Something that stops the Argentineans seems to be a custom difficult to
incorporate in "Mecca of the garlic sausage steak".

GRASS And IMMUNITY

Citrus (Citric)

Citrus (several species)

Here is a good well-known oil class with many properties just discovered.
D-limonene is the main component of the essential oil of the orange and
other citric fruits. Also it happens coarsely in the vegetal kingdom,
particularly in those species that produce essential oils, flavors and
aromas.
This compound belongs to a known natural compound class like terpenos,
that next will equal to the carotenoid bioflavonoides and in their
applications.
Near ten animal studies they have been published, which demonstrate that
d-limonene in medicinal diets is able to reduce the incidence of the
chemically induced cancer as well as to delay its appearance. Elson and
some colleagues of the University of Wisconsin are at the moment the
leaders in this field. In several studies, they demonstrated that
d-limonene in medicinal diets reduced the cancer of breast noticeably
induced by dimetil-benzatraceno. The used dose is this study was of 1000
parts by million, or 1 gram by kg of diet. Using the same system model,
later they demonstrated that the essential oil of orange (85% d-limonene)
was more effective than d-limonene pure in the prevention of the formation
of the tumor. Thus, the natural occurrence of terpenos in the oil of
orange more than in d-lomonenes also has activity anticancer. Deeper
investigations of this group revealed that d-limonene in medicinal diets
is effective to revert preformed tumors, as were demonstrated by an
increase of the regime of regression of the tumor. Finally, Elson and its
associate observed recently that d-lomonene in medicinal diets was
effective to reduce the number of chemically induced mammary tumors in
rats when was provided so much during the phase with initiation like
during the phase of promoci?n/progreso.
The mechanisms of action of d-limonene against the cancer well are not
included/understood, but they can involve the improvement of the systems
of metabilizaci?n of drugs like glutathione-S-transferases. The capacity
of d-limonene to revert tunores preformed and to inhibit the growth of the
tumor during the phase of promoci?n/progreso of the cancer suggests a
inmunoestimulante action, and some recent evidence maintains east
concept.
As an extra benefit, d-limonene is a powerful reducing natural compound of
the cholesterol. It acts inhibiting the same enzyme (HMG-coenzima To
reductasa) that prescriptas of the cholesterol is object of several
reducing drugs such as lovostatin. If these actions will not be
sufficient, d-limonene is also powerful a dissolvent agent of
calculations.

- Presentation: In bottles of 60 500 soft capsules of mg. Of essential Oil
of orange,
certificate in a harassing concentration of d-limonene of 85% each one.

- Recommended Use: 1-2 daily capsules preferredly during the meals.

Email:  pacientes@canceralternativo.com.ar

www.canceralternativo.com.ar

NATURAL TREATMENTS
POISONS OF?DICOS IN THE TREATMENT OF THE CANCER

B. Cobraminol?tico: Solution Gal?nica Antitumoral

"the concentrated protoenzim?tico arsenal in the of?dico poison,
denominated Direct L?tico Factor technically, responds to digestive
necessities exclusively"

The poisons drive according to a "strategy" in which two different
although synchronous effects can be distinguished clearly: "the
curarizantes" tractions of the effect (neurotoxinas), that immobilizes the
prey, which is swallowed whole (not chewed nor salivada); and the
fractions of the poison of proteolytic effect, which have a specific
predilection by certain visceral weaves, depending this selectivity to the
sort to which ofidio belongs.

Although the chemical structure of poisons has an enzymatic composition
common, present in all of them, each of?dico sort has catalytic
concentrating that distinguishes them.

Thus for example, the Crotoxina is a polypeptide structure with a basic
component and another only present acid in the Crotalidae; which outside
defined chemically like L-Arginina ?sterhidrolasa (TAME: this one methylic
one of the toluensulfonil L-Arginina), Peptide-peptide hidrolasa (3.4.4)

The numbers indicate the number of order of the of?dicos biocatalizadores
in the Classification the International of the Enzyme Committee of the
Union the Biochemical International.

In the course in which doctor Calmette and doctor Guerin worked associate,
which among other advances even resulted in vaccine BCG, by
Calmette-Guer?n Bacillus, used in Melanomas, was developed a febrile
international investigation, initiated in fact to principle of century in
France, on chemistry, biochemistry and pharmacology of of?dicos poisons.

Although already in 1883 doctor Ameden used successful the poison of
Cr?talus to prevent the convulsions caused by the Tetanuz, was just until
1915 when the antielap?dico serum was standardized like "isof?nica
solution of the hyperimmunized equino animal globulins".

He was in the years 20 that doctors Vital Brazil and Monoelesser developed
exhaustive investigations on the action of the of?dico poison in the
treatment of the Leprosy.

The clinical conclusions, casuistry and the enzymatic segments used by
these investigators, Brazilian and North American respectively, were
communicated doctor Calmette who was excited by the full effects obtained
on lepers in Cuba.

By then Calmette already had finalized him clinical experimentation in
hundreds of patients, as much with the "fractions of Curarizante effect",
like with those of Selective Proteolytic effect of the poison of Elapidae
- Naja attenuated Tripudians- 1/100.000. Obtaining by a powerful side
analgesia without toxicity nor secundarismos, as well as remission in the
great majority of the patients with cancer, mainly in which they
presented/displayed carcinoma of ovary, intestine and prostate.

Monoelesser and Taguet summarize all the aspects of these investigations
in a communication that outside presented/displayed in the Medicine
Academy by illustrious professor Dr. Gassel the 14 of March of 1933.

The same Gassel 1? of April of 1933 presented/displayed the confirmation
of the capacity analgesic, discovered years before, experienced in more
than 1200 cases of patients with nonatenuables pains not even with
injectable morphine.

But the beginning of 2da. World war interrupted and darkened all these
efforts and advances; mainly so that some fractions of of?dicos poisons
became "strategic factors" like antidotes against the chemical and
bactereol?gica war. In addition to the irruption at the end of the war of
"panacoa" metil bis (2 cloroetil) amine (nitrogenadas mustards) and its
manifold variant in the treatment of the cancer.

In 50 years doctor Vital Brazil (son) next to doctor Avelino District
(eminent Argentine doctor), made important investigations on poison of
Cr?talus durissus terr?ficus discovering the Veratr?nicas properties of
these.

At the moment many deprived international laboratories make use of the
most valuable of?dica investigation, in the drug design for human use.

For this specific enzyme separation, of the total mosaic that constitutes
the poison, we did not use chemical reagent some, but a novel methodology
of automatically controlled emptiness and a rank of condensation that goes
of the room temperature to -20? C, separating selectively the looked for
enzymes.

The rank of purity of each of each fraction we identified it with
spectrometer equipped with a registry of aspects that registers above of
17000 active principles, although in some phases of the process we must
make use to the GCD - chromatography with mass spectrometry -.

Although all the saying until is secondary here in relation to the
high-priority thing, that means the sterility of the atmosphere in which
it is processed, as well as the temperature in the same one, our sterile
area works to controlled atmosphere, all the air happens through
activated-carbon filters, which maintains the atmosphere free of esporas,
they polen, steam of water and to 5? C, but even so the manipulations must
be made under Flow Laminate Horizontal.

These are, we say, single some of the salient aspects of the complex
methodology of elaboration.

ACTIVE PRINCIPLES OF OFIDEOS:

COBRA: Citol?tico, analgesic, regulating par excellence metabolic, because
fosfolipasas A2 of naja is a fraction purified in this case one naja, when
entering the organism "sticks" to the tumorlike cell very "loaded" this
one of phospholipids and it begins it to lisar of this form: it does not
touch any other affected cell.

BELL: Analgesic - Citol?tico, but of greater being able analgesic. It is
also a purified fraction chromatographically of Crotalus Durissus
Terrificus, happening to become one fosfolipasa A2 of crotalus.

INDICATIONS CLINICAS

ONCOLOG?A

Tumors of head and neck
Tumors of breast
Tumors of the urogenital apparatus (masculine and feminine)
Hematol?gicos tumors
Tumors of soft parts (Melanomas-Sarcomas-Cordomas, etc.)
Tumors of lung and esophagus
Tumors of the gastrointestinal apparatus
Tumors of skin

COLGENOPAT?AS

Sist?mico erythematous lupus
Reumatoidea arthritis
Progressive sist?mica sclerosis
Knotted Poliartritis
Anquilosante Espondilitis
Syndrome of Reiter
Psoriasica arthritis
Youthful reumatoidea arthritis

NEUROLOGICAL

Sclerosis in plate
Angioesclerosis or disease of Alzehimer
Idiop?tica acute Polineuritis
Progressive muscular atrophy

The Morning of the South - (regional Information of Neuquen and Ri'o
Negro.) EXTERNAL RECOGNITION FOR CROTOXINA; CREOLE POVERTY

PARANA. - The magazine Clinical Cancer Research, official organ of the
American College of Clinical Cancer Research of the United States, by the
end of published the results of a faced investigation the decade last in
Parana, over the effects of the crotoxina in the cure of the cancer. In
his conclusions it is specified almost that the drug demonstrated
statistically, in the 80 percent of the oncol?gicos patients treated
experimentally, a diminution or disappearance of the pains, and a greater
general well-being of the patients. Nevertheless, it was not possible here
to be followed with the investigation by the lack of resources.
The mentioned magazine put under the work of the Argentine scientists an
evaluation in which, due to the specificity of the subject, they also
participated like investigating consultants of the Research laboratory of
the General Massachussets Hospital of Boston (University of Harvard).
After a detailed analysis, the magazine decided to publish the work with
the title "Phase I and Pharmacokinetics Study of Crotoxin in Patients UIT
Advanced Cancer (vol. 8, 10033-1041), - Phase I. Farmacocin?tico Study of
the Crotoxina in Patients with Advanced Cancer granting thus international
recognition to him to the investigation developed in our country, that had
to be suspended by lack of resources.
The studies on the effects of the crotoxina, a mediation that some years
ago appeared as an alternative for the cure of the cancer, were made in
the hospital San Mart?n of Parana and were in charge of an equipment
directed by the technical associate of the Conicet and director of
Medicine the Educational Unit of Parana (UDAM), Jorge Cures.

THE STUDY OF THE POISON OF THE BELL SERPENT CAN LEAD DRUG ANTI-CANCER

Subject of study: The surprising molecular similarity of enzymes of the
poison of bell serpent and the cells of the human cancer can help
naturally to destroy the disease with new powerful drugs.

Batimastat, a manufactured experimental drug in England, was found to stop
the invasion of the cells. "Like putting a sticky tape in the mouth of a
lizard" according to the Dr Edgar Meyer, a biochemist of the Experimental
Department of Agriculture of Texas. The findings of the equipment of
investigation of Meyer are reported in the "April Proceedings of the
National Academy of Sciences". The work was a collaboration between the
University of Texas and the Dr Sends to Liotta of the laboratory of
pathologies of the National Cancer Institute de Betheseda, Md.

The previous observation of Meyer on the molecular structure of enzymes of
the bell poison, that is almost identical to the cell of human cancer, has
helped the finding of ways to block the extension of the cancer leaving
the search of new inhibitors.

"When the poison is injected the human who is pricked by a serpent the
fluid it penetrates around the weave to enter the blood" explained Meyer.
"In the same way the cell of the tumorlike met?stasis penetrates around
the membrane to enter the circulatory system".

It says that the maquillaje of enzymes of the poison differs but the
molecules have the same structure fundamentally that have the cancerous
cells. Its model constructed in 3? dimension with a program of special
computer shows to the structure with a mouth opened with a Zinc atom and a
water molecule in means. This present Zinc in both (cancerous cell and
poison of serpent) begins to destroy the healthy weave.

The scientific challenge has been to find a form to block the opening,
thus this way prepares the process from the beginning. "If You Want to
control the degenerative process, You Must go behind Zinc," said "" This
is the action mechanism ".

"This is a powerful chain that makes a first cut in a link. This is
debilitated and the hole can be made more and greater until the chain
becomes broken completely "Meyer added.
The biochemist noticed that the cancer is an extremely complex disease,
"but these are steps that they define that it happens and when. Soon You
See inhibitors that are good to stop this process ".

To understand this process was possible behind Dachuan Zhang, one of the
students graduated as Meyer, that found a way to let grow crystals of the
enzyme of the poison. This it gave to the equipment an atom puzzle him
that was located together in a molecular structure in 3? dimension within
a computer.

Using eyeglasses of 3? dimension in the laboratory of Meyer in the
University of Texas, the equipment can visualize "a unique cavity within
which the inhibitor has entered" as ring the finger ".

The investigation showed that Batimastat, deeply thus ties to the
structure, this way coming up that the poison or the cell of the tumor
begins their destructive work.

Meyer said that the hard enzymes of human cancer are available, the viper
poison enzyme was useful in this test because it is a very stable molecule
available and quickly susceptible to be cloneada easily.

A difference with the new experimental drug, said he, is that the present
methods of chemotherapy "poison" the body filling first by a fast growth
of the cancerous cells but causing indirect effect on the other side in
the healthy system of the body, Batimastat is an example of a new
developed drug generation to go direct to the problem and to close those
detrimental enzymes without affecting the others.

In experiments with humans the drug has been injected in a solid form,
which slowly goes within the solution, he said.

"This is another challenge (to administer the drug orally). This has
passed secretly the system digestive and circulatory to turn it the target
"Meyer it added.

It said that these new discoveries are promising, but some questions are
still without responding like doing that the process "to chew the healthy
cells" begins, and once the process begins how to make stop it.

The equipment has designed drugs of pending proposals with the U.S.
National Cancer Institute Cooperative Drug Discovery Group, said he.

STRUCTURE OF COMPLEX CROTOXINA

Jaap Brink and Wah chiu

Center W. M. Keck for Computerized Biology and the Department of
Biochemistry Verna and Marrs McLean, School Baylor de Medicina.

The Crotoxina complex is the main neurotoxina of the South American
serpent of bell, Crotalus durissus terrificus with a molecular weight of
24 kDa. The protein is to heterodimer of the subunits To and B, with the
subunit To assigned to a function of chaperone and the B drive that the
neurotoxic activity takes. This last activity is exerted in both sides of
the neuro-muscular functions. Still they lack to determine solely the
physiological and farmacol?gicos aspects of the protein for a structural
base. The crotoxina complex crystallizes easily in two dimensions (2D) and
thin crystals of three dimensions (3D) that are treatable in a
cristalogr?fico electronic study. Series Inclined with patterns of
electronic crystal diffraction absorbed in glucose of 128 ? of thickness
were reunited in 400 an electron microscope JEOL4000EX kV using a camera
CCD of scanned slow Gatan 679. This profit is useful because it
facilitates combined information of several crystals, which can be
difficult to obtain due to the variation of thickness between crystals, or
due to the lack of plain of crystals. The combination of 6 series inclined
with patterns of diffraction 353 was complimented with scale of PROTEIN
use and computerized factors of temperature from found reflections common
in any film game. The refinement of the direction of the patterns of
individual diffraction in the information game took place 3D combined by
variation of the azimuth and rakes using MERGEDIFF. The continuous
diffraction in z * of the information game 3D refined was fixed using a
function sinc with a wide one of 17196.A1 using SYNCFIT.
The game of intensity information combined 3D was included/understood by
55.000 reflections corresponding to 75% of 3,3 integrity and extended to ?
in hk0 and 4,2 the plane ? in direction z *. the total of Rmerg is 0,26
with a Rsym of 0.15. Some curves turned out to adjust enough good with a
Rmerg of 0.16, inasmuch as others combined poorly enough to Rmerg 0.45.
the analysis of individual inclined series revealed the absence of the
symmetry waited for in plane. These observations suggest a problem in the
packing of the crystals, that we hoped to direct negatively by means of
the processing of inclined series of colored complex crystal images of
crotoxina.

FEEDING

The pharmacy is in verduler?a

Prog. Cientifica and Tecnica de Fundacion Campomar

Source: Cancer Research Vol. 52,7 - April 1992
Cience Vol. 257 - September 1992

The investigations agree: as the grandmother said, the health begins in
the table.

For the specialists in nutrition, the nourishing habits of most of people
let so much wish, as far as the quality and composition of the diet, that
some have gotten to perhaps affirm - somewhat exaggerated that "the man
digs his tomb with his own teeth".
But, what has of the many foods that, on the contrary, they are beneficial
for the health?
For a long time studies have been known epidemiologists who demonstrate
the existence of a direct correlation between the habitual consumption of
determined vegetal and the diminution the risk of contracting certain
types of cancer.
However, recent scientific researches have been able to determine or the
active principles responsible for the anticancerigenic action of such, in
agreement with a report published in the magazine Cancer Research.

Green and healthy
The list of vegetables and fruits that conform the arsenal of "enemies of
the cancer" is as extensive as varied.
A place of privilege in the same one occupies vegetables pertaining to the
group of the cruc?feras. Among them we found to the coliflor, repollo and
br?coli. An equipment of investigators of the American Foundation for the
health, of New York, found that comjunto of known compounds as
organosulfurados - present in these vegetables they can inhibit the cancer
of laboratory animal colon, according to the Science magazine. This
finding has individual importance for the Americans, considering who such
disease represents the second cause of death by c?nceren the United
States.
The cruc?feras also could be effective to prevent the development with the
lung cancer, in individual in people smokers, in agreement with Fung-Lung
Chung, chemistry of the same foundation. One of the main people in charge
of the damages produced by the tobacco at pulmonary level is a group of
chemical substances - the nitrosaminas - of which most injurious is
well-known generically like NNK. The expert of Chinese origin found that a
set of compound - called isotiocianatos-, presents in the coliflor and its
relatives, they inhibit the production of the cancer of animal lung
exposed in experimental form to the NNK. Equal property demonstrates
certain extracts of citrus (D-limonenos); of vegetables of the family of
the lili?ceas - garlic, onion, puerro, ?chalotte- (also organosulfurados),
and of the plant of the tea.
For that they are not used to incorporating no of these vegetables in the
daily diet still is left the soybean sauce. Michael Pariza, an
investigator of the University of Wisconsin, discovered that this
condimento has the property to inhibit the cancer of laboratory animal
stomach. According to the scientist, the active principle responsible for
such action would be a well-known chemical substance by the experts like
HEMF. "Only one small portion of the pure extract of HEMF -25 parts by
million in the diet of the animals - it was sufficient to reduce to a 75%
the number of stomach tumors", affirms Pariza.

Moment of action
The specific mechanisms of anticancerigenic action of many of vegetables
are not still well included/understood by the specialists.
According to Lee Wattenberg, of the University of Minnesota, the contained
antitumorlike compounds in vegetables can be classified in three
categories, in agreement with the moment for exerting their activity. In
this sense, a first group is conformed by those substances that prevent
the development with a tumor inhibiting to precursory chemical compounds
of this process. Secondly are those that they prevent that the carcinogen
agents can arrive or react with the cells "white" of each corporal weave.
Finally they are those substances that act suppressing the tumorlike
growth of cells that previously have been exposed to carcinogen doses of
sufficient to develop the disease.
Beyond the determination of the reasons by which certain vegetables have
anticancerigenic properties, the nutricionistas experts recommend to
consume generous rations of vegetables and fruits with the daily diet.
Something that stops the Argentineans seems to be a custom difficult to
incorporate in "Mecca of the garlic sausage steak".

GRASS And IMMUNITY

Citrus (Citric)

Citrus (several species)

Here is a good well-known oil class with many properties just discovered.
D-limonene is the main component of the essential oil of the orange and
other citric fruits. Also it happens coarsely in the vegetal kingdom,
particularly in those species that produce essential oils, flavors and
aromas.
This compound belongs to a known natural compound class like terpenos,
that next will equal to the carotenoid bioflavonoides and in their
applications.
Near ten animal studies they have been published, which demonstrate that
d-limonene in medicinal diets is able to reduce the incidence of the
chemically induced cancer as well as to delay its appearance. Elson and
some colleagues of the University of Wisconsin are at the moment the
leaders in this field. In several studies, they demonstrated that
d-limonene in medicinal diets reduced the cancer of breast noticeably
induced by dimetil-benzatraceno. The used dose is this study was of 1000
parts by million, or 1 gram by kg of diet. Using the same system model,
later they demonstrated that the essential oil of orange (85% d-limonene)
was more effective than d-limonene pure in the prevention of the formation
of the tumor. Thus, the natural occurrence of terpenos in the oil of
orange more than in d-lomonenes also has activity anticancer. Deeper
investigations of this group revealed that d-limonene in medicinal diets
is effective to revert preformed tumors, as were demonstrated by an
increase of the regime of regression of the tumor. Finally, Elson and its
associate observed recently that d-lomonene in medicinal diets was
effective to reduce the number of chemically induced mammary tumors in
rats when was provided so much during the phase with initiation like
during the phase of promoci?n/progreso.
The mechanisms of action of d-limonene against the cancer well are not
included/understood, but they can involve the improvement of the systems
of metabilizaci?n of drugs like glutathione-S-transferases. The capacity
of d-limonene to revert tunores preformed and to inhibit the growth of the
tumor during the phase of promoci?n/progreso of the cancer suggests a
inmunoestimulante action, and some recent evidence maintains east
concept.
As an extra benefit, d-limonene is a powerful reducing natural compound of
the cholesterol. It acts inhibiting the same enzyme (HMG-coenzima To
reductasa) that prescriptas of the cholesterol is object of several
reducing drugs such as lovostatin. If these actions will not be
sufficient, d-limonene is also powerful a dissolvent agent of
calculations.

- Presentation: In bottles of 60 500 soft capsules of mg. Of essential Oil
of orange,
certificate in a harassing concentration of d-limonene of 85% each one.

- Recommended Use: 1-2 daily capsules preferredly during the meals.

Email:  pacientes@canceralternativo.com.ar

www.canceralternativo.com.ar

My cancer was Curied with 150mCi of 131I.
But I don't think that's what this guy means.
bj

http://www.hoovers.com/usana-health-sciences,-inc./--ID__51987--/free-co-factshe
et.xhtml

Health is a matter of science at USANA Health Sciences. The company makes
nutritional, personal care, and weight management products mainly sold
through a network of more than 85,000 independent distributors in North
America, the UK, and Pacific Rim countries. Nutritional supplements,
including top-sellers USANA Essentials and Proflavanol, account for about
two-thirds of the firm's sales. Additional products include sunscreen,
shampoos, lotions, and toothpaste, in addition to the L*E*A*N (Lifestyle,
Education, Activity, and Nutrition) Team weight-management program. Founder
and CEO Myron Wentz owns over half of the company"

Filter another Quack/spammer !

Poster : Figjamok
email :   figjamok@optusnet.com.au

<figjamok@optusnet.com.au>
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