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Medical Forum / Diseases and Disorders / Breast Cancer / January 2004

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Sleep, Tamoxifen, etc. -- The Next Chapter

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A. P. Thorsen - 19 Jan 2004 22:10 GMT
OK, so I previously mentioned that my sleep doc wanted my onco doc to
take me off Tamoxifen to see whether it was causing my sleep
interruption problems.  My onco didn't want to do that, and suggested
switching me to Arimidex, which concerned me because I'm not sure I'm
truly menopausal.  (This is starting to sound like a soap opera summary!)

Just had a phone conversation with the onco, *not* through the nurse
this time, and here's where we are now:  He wants to have my FSH levels
checked, then, if menopausal, put me on Arimidex; or, if not menopausal,
try injections of Fulvestrant (Faslodex) every 28 days.

I'm just starting to research this on the web, but have some questions:

#1 - Has anyone comments on their experiences with Arimidex or
Fulvestrant, especially vs. Tamoxifen?

#2 - Also, Fulvestrant's prescribing info also indicates it's for
post-menopausal women, but I see that the mechanism of action is the
drug binding to the estrogen receptors of tumors, presumably in a
similar way to Tamoxifen.  From reading between the lines, perhaps the
"post-menopausal" indication is based only on how the drug was tested.
I'll keep reading up, but if anyone's been down this research track
ahead of me and can offer pointers, that would be very much appreciated.

Thanks!

Ann T.
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allan grossman - 20 Jan 2004 12:33 GMT
> OK, so I previously mentioned that my sleep doc wanted my onco doc to
> take me off Tamoxifen to see whether it was causing my sleep
[quoted text clipped - 19 lines]
> I'll keep reading up, but if anyone's been down this research track
> ahead of me and can offer pointers, that would be very much appreciated.

Ann, Deborah just started Arimidex on New Years' Eve.  We're not
really sure she's post-menopausal so he added Zoladex every month to
make sure her ovaries aren't producing estrogen.

Last time we tried Zoladex Deborah had awful hot flashes and
discontinued the treatment after one injection - but that was three
years ago.  This time everything's going pretty smoothly.  Zoladex is
pretty well-tolerated.
 
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