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Medical Forum / Diseases and Disorders / Breast Cancer / January 2004

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Sleep, Tamoxifen, Arimidex, Menopause, Chocolate

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A. P. Thorsen - 16 Jan 2004 18:05 GMT
I may've mentioned that I've been wrangling with sleep interruption
since BC treatment started.  I go to sleep easily, but wake up
frequently (going back to sleep is also easy).

I've done *everything* I can think of (self-hypnosis CDs, way more
exercise, dim lights in the evening, manipulating bedtime/rising time,
avoiding naps, yoga, meditation, aromatherapy pillow sprays, drug (OTC &
prescription), sleep clinic, and more I'm forgetting.)

The sleep doc wanted me to try going off Tamoxifen for 3 weeks (pure
speculation based on timing of the problem starting, I believe).  My
oncologist said "Nope".

So, they pow-wowed, and the latest is that the oncologist wanted me to
try switching to Arimidex.

As background, I'm 48, and on another front have been having some slighy
vaginal blood spotting we're looking into . . . but I think maybe the
old bod' is just trying to have a last-gasp menstrual cycle if it can
work its way up to it.  Last time my FSH levels were checked, around 2
years ago, they were ambiguous -- solidly in a range where
"pre-menopausal" overlaps with "normal reproductive phase".

I thought aromatase inhibitors were only for the menopausal, so I
cross-examined the oncologist's nurse when she advanced the Arimidex
plan.  (She said, "Gosh, you really have researched a lot about this
stuff, haven't you?" <g> I'm thinking "Um, it is life-threatening,
right?") The onco doc won't be in until Monday, so I'm in "wait & see" mode.

Since this group usually seems more tuned in that most medical
professionals, I thought I'd run the whole mess by y'all & see if any
one has any thoughts on the Sleep/Arimidex/Tamoxifen/Menopause subject.

Oh -- and I just put "chocolate" on the subject line so fellow
choco-holics would read it.  I don't think it has anything to do with
anything else in this post, but it *is* good, innit? (I know it has
caffeine, so it might keep me awake if I eat too much. <g>)

P.S. - on another front, I'm about to try a hypnotherapist -- for the
sleep interruption, not the chocolate!

Thanks, as always, for whatever comments you may have,

Ann T.
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Kaye301 - 16 Jan 2004 18:54 GMT
Ann wrote << I may've mentioned that I've been wrangling with sleep
interruption
since BC treatment started.  I go to sleep easily, but wake up
frequently (going back to sleep is also easy). >>

Hi Ann, just wondering are you having any caffeine in the later afternoon?  
Also, perimenopausal as well as menopausal conditions can interrupt sleep.  One
thing that I find helpful and find that has helped me sleep better is getting
regular exercise--particularly sometime in the evening--such as 30 min. on the
treadmill.
Now, I have a question.  If you go to sleep easily and then after you wake up
are able to get back to sleep easily, why is it a problem?
I think sleep is important but I am not so sure that there is any one way that
is best to get it.
A. P. Thorsen - 16 Jan 2004 19:19 GMT
Thanks for answering, Kaye!

> Hi Ann, just wondering are you having any caffeine in the later afternoon?  

No, I try to avoid that.

> Also, perimenopausal as well as menopausal conditions can interrupt sleep.  One
> thing that I find helpful and find that has helped me sleep better is getting
> regular exercise--particularly sometime in the evening--such as 30 min. on the
> treadmill.

Three (occasionally more) nights a week, I row (rowing machine in
winter, boat in summer) for half an hour to an hour and a half (in 2-20
minute chunks with 2-3 minutes rest in between, depending on training
objectives).  Normally, that gets my average heart rate in the 150-170
bpm range during the "work" part of the cycle.

I weight train twice a week, maybe 8-12 exercises, depending on the
workout plan, 2-3 sets of 3 (if I'm working strength) to 15 (if I'm
working endurance) reps each, trying to work at a weight where the last
rep or three are quite difficult.

I've just started swimming lessons, practicing half an hour or so 2-3
times per week.  Most of that happens after 6PM in the evening.  Yoga
and other stretching, 10-30 minuts most days.  Plus occasional long
walks, biking, cross-country skiing, canoeing, aerobics, and such
miscellany in the course of enjoying myself, of course!

I had expected increased exercise to improve my sleep; it didn't.  It
*did* improve my energy level during the waking hours, and pepped up my
metabolism generally.

For those of you wondering whether evening exercise is getting my pumped
up & is therefore part of the problem:  I don't think it is.  The sleep
interruption has been more-or-less unchanged since before I started the
exercise.

> Now, I have a question.  If you go to sleep easily and then after you wake up
> are able to get back to sleep easily, why is it a problem?
> I think sleep is important but I am not so sure that there is any one way that
> is best to get it.

I'm not getting enough deep sleep.  I have cognitive problems (memory,
concentration, complex reasoning) that -- from my perspective, but
thankfully so far not from my boss's perspective -- interfere with my
ability to do my job.  Some of that is probably chemo-brain, some may be
Tamoxifen-related, but I'm hopeful that getting more REM sleep might
improve the picture.

I appreciate your help, Kaye!

Ann T.
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Kaye301 - 16 Jan 2004 22:37 GMT
Ann wrote << I'm not getting enough deep sleep.  I have cognitive problems
(memory,
concentration, complex reasoning) that -- from my perspective, but
thankfully so far not from my boss's perspective -- interfere with my
ability to do my job.  Some of that is probably chemo-brain, some may be
Tamoxifen-related, but I'm hopeful that getting more REM sleep might
improve the picture.

I appreciate your help, Kaye!

This my 2nd attempt to answer--wrote out a long response and was knocked
off-line just as I was about to send it--aahhh aol...anyway,
I do understand your concerns re memory and concentration.  I am not so sure
that sleep makes that much of a difference, per se because I don't think
studies have controlled for hormonal changes that co-occur.
My mom was concerned about regular sleep habits as we were growing up--she was
an R.N., and made sure she slept regularly--good amount each night.  The only
one with sleep probs in our family, I think, was my dad--who snored and had a
hard time getting up each morning.
I do know that I resisted sleep--thought it was a waste of time ;-)  I know we
need it and the purpose for it and on some days when deprived I am so
exhausted, but I have learned a few coping techniques.  One that helps me the
most is a power 'nap' or actually meditative state for about 20 min.  On those
nights when I have had very little sleep, two of these 'meditations' is
generally all it takes for me to get back into the thick of it.
I think each person's sleep habits are very different due to their physiology
and know they vary amongst family members.  I am not sure who came up with what
is 'best' for all (if anything can be).  Each of our 3 kids have had very
different sleep patterns--and still do--basically the same that they had since
they were infants.
My oldest didn't sleep much--since day '1'   She was premature by 5.5 weeks and
had to be re-hospitalized after her wt. dropped and she became hypothermic.  I
recall her dr. saying how alert she was and that smarter babies slept less (not
true for all, though).  She didn't sleep much as a baby--had 2 sitters quite on
us--one let her scream 3 hours; another let her scream 6 hours.  I tried the
modification programs--they didn't work.  Finally we found a sitter that said
her kid was the same.  She put her daughter in the backpack and walked around
the house with her.  She did that for my daughter and all was fine and then
when she could move around on her own--all was more than fine.  (that is not
true for all, of course).  She always craved stimulation and still does.  When
she was 4 she asked if we could move to another state because she thought it
was so 'boring' being in the same place.  She went on to graduate high school a
year early with honor of 'best academic-all around student.  She was accepted
to medical school, during her sophmore year of college, pending completion of
her B.A.  She could easily have done it in 3 years but decided to take some
classes she always wanted to take and then last semester--reduced load in order
to dance professionally.  She graduated with 2 B.S. degrees (neuroscience and
dance/human movement).  If she took one more class she would have had a B.S. in
biology and if she wrote a paper she could have had a B.S. in biology--all
within 4 years.  She is currently both a professional dancer/choeographer and
3rd year medical student.  She has applied to take off next year to do research
in some 3rd world country.  (I am not overly thrilled about that nor do I think
her current boyfriend is either...we shall see...).  I forgot to mention it is
not unusual for her to go 48 hours without sleep--she is the only person I have
ever known to do that without a problem.  Then she will sleep hard--very hard
which she has always done.     Then there was our middle daughter--the complete
opposite who needed so much more sleep---took 2 naps/day until she was in
kindergarten, and if she didn't or doesn't get enough sleep everyone around her
is sorry.  She was always a light sleeper--would wake up easily though if there
were any noise.  She is also quite bright but definately needs her sleep, a
structured environment, and likes things to be more calm.  
Our youngest daughter seems to be in between in terms of need for sleep.
I grew up hating to nap--recalling the feelings of torture when I was made to
nap.  I remember putting on a flashlight to read after I had gone to bed.  My
sister, on the other hand, always needed more sleep and still does.
Again, I think that everyone's need for sleep varies, and is biologically
based.  It may or may not be genetic but assume there must be some predisposed
factors involved.  Again, it is a different story though if the lack of sleep
is seriously affecting one's performance.  

<< I'm not getting enough deep sleep.  I have cognitive problems (memory,
concentration, complex reasoning) that -- from my perspective, but
thankfully so far not from my boss's perspective -- interfere with my
ability to do my job.  Some of that is probably chemo-brain, some may be
Tamoxifen-related, but I'm hopeful that getting more REM sleep might
improve the picture.

I appreciate your help, Kaye!

This my 2nd attempt to answer--wrote out a long response and was knocked
off-line just as I was about to send it--aahhh aol...anyway,
I do understand your concerns re memory and concentration.  I am not so sure
that sleep makes that much of a difference, per se because I don't think
studies have controlled for hormonal changes that co-occur.  I guess I don't
have much of a problem--although not sure how someone would view my sleep
patterns, objectively.  I fall asleep during movies, plays--whenever I sit down
and am passively taking in information--including afternoon lectures--coffee
doesn't even help...
Tony Lima - 24 Jan 2004 23:57 GMT
>Thanks for answering, Kaye!
>
>> Hi Ann, just wondering are you having any caffeine in the later afternoon?  
>
>No, I try to avoid that.

Ann, some chocolate candy has some caffeine content.  Caveat
chocoholic. - Tony

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J - 16 Jan 2004 18:58 GMT
> I may've mentioned that I've been wrangling with sleep interruption
> since BC treatment started.  I go to sleep easily, but wake up
> frequently (going back to sleep is also easy).

Maybe an overnight sleep study to see if there's a treatable sleep disorder.
J
A. P. Thorsen - 16 Jan 2004 19:30 GMT
>>I may've mentioned that I've been wrangling with sleep interruption
>>since BC treatment started.  I go to sleep easily, but wake up
>>frequently (going back to sleep is also easy).
>
> Maybe an overnight sleep study to see if there's a treatable sleep disorder.

Been there twice -- I'm embarrassed I left that out of my original post
(duh)!  Diagnosed with mild sleep apnea, now using a C-PAP mschine
nightly, which seems to have improved my soundness of sleep, but not the
waking up periodically.   When they did the titration for the C-PAP,
they gave me a sleeping pill (the name escapes me now; one of the
current popular darling drugs for insomnia).  I slept through the night
that night, for the first time in 3 years, but never again . . . despite
trying the same pills again later.  All they did was leave me groggy in
the morning; I still woke up at the same intervals.

BTW, I have the same sleep interruption schedule away from home that I
do at home, so I don't think it's environmental.

The sleep studies were the basis for the sleep doc getting the idea that
stopping Tamoxifen was the next good idea (!).  As a stopgap, he's given
me Sonata (a short-acting hypnotic) to take the first time I wake up
each night.  It seems to slightly prolong my second sleep interval of
the night, which is definitely a help, but after that interval I wake up
every hour an a half or so just like before.

Digression that may not make sense outside the U.S.:  A friend loaned me
her stuffed-animal Serta Counting Sheep when I went to the sleep clinic.
 Since there was a bunch of waiting around involved, I amused myself by
taking digital photos of said sheep filling out paperwork, investigating
the sleep-monitoring equipment, trying on my C-PAP, eating breakfast,
getting into the shower, etc., and was able to return the stuffed animal
to my friend with a captioned photo scrapbook . . .

Thanks, J, for your suggestions!

Ann T.
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J - 16 Jan 2004 20:10 GMT
> Been there twice -- I'm embarrassed I left that out of my original post
> (duh)!  Diagnosed with mild sleep apnea, now using a C-PAP mschine
[quoted text clipped - 5 lines]
> trying the same pills again later.  All they did was leave me groggy in
> the morning; I still woke up at the same intervals.

if it's a tricylic sleep med (which are long-acting) example Elavil/amitriptyline
(and there's others)  it can cause:
dry mouth and groggy, so you would perhaps need:
heated humidifier for your CPAP
take it split at night: half around dinner time, the other half as usual before
bedtime, so less groggy in the a.m.
oh and when I was on those, I had to go to bed by 10 to be up at 6a.m and drink
lots of coffee to wake up, so I wish I'd known at the time about splitting the
dose in case it would have made a difference.

(it's clear to me you are not getting good quality sleep, even if you are going
back to sleep quickly)

Tricyclics can cause/exacerbate RLS (restless leg syndrome) which can cause
frequent wakeups.
The only way to know for sure on perhaps all of those is a sleep recheck on the
medication(s) and trial of heated humidifier, and they put wires on the legs to
check for Restless leg syndrome. If that's the case, a different type of sleep
medicine is better.
(of course, sometimes the dose is too high also)

> .  As a stopgap, he's given
> me Sonata (a short-acting hypnotic) to take the first time I wake up
> each night.  It seems to slightly prolong my second sleep interval of
> the night, which is definitely a help, but after that interval I wake up
> every hour an a half or so just like before.

Do you take both? My brother and many others do, as long as there's no
contra-indcative reasons.

> Digression that may not make sense outside the U.S.:  A friend loaned me
> her stuffed-animal Serta Counting Sheep when I went to the sleep clinic.
[quoted text clipped - 3 lines]
> getting into the shower, etc., and was able to return the stuffed animal
> to my friend with a captioned photo scrapbook . . .

:-) not aware of what that is but I'm certainly aware of being one of the sheep.
One night, the staff ordered out pizza for some of us who were at the end of the
line on the preparation (wires etc)
Yummy, but I still can never sleep good in those places, I prefer my own bed.
J
A. P. Thorsen - 16 Jan 2004 20:58 GMT
> if it's a tricylic sleep med (which are long-acting) example Elavil/amitriptyline
> (and there's others)

Ambien.  It was Ambien.  I don't think I've taken a tricyclic.  OTC
sleep aids (diphenhydramine hydrochloride), Xanax, and . . . mmmm, what
was the other anti-depressant I tried? . . . BuSpar, I think -- didn't
have any dramatic effect on the sleep cycle.  (To be clear, I was
prescribed the Xanax & BuSpar for cancer-related anxiety, not for sleep
interruption.)

> it can cause:
> dry mouth and groggy, so you would perhaps need:
> heated humidifier for your CPAP

I have one of those, too!  Hey, I've got *all* the cool toys <g>!

> take it split at night: half around dinner time, the other half as usual before
> bedtime, so less groggy in the a.m.

Good thought! I'm not sure this will work with Ambien, though . . . the
info sheet says "Ambien works very quickly. You should only take Ambien
right before going to bed and are ready to go to sleep."  I've got a
couple around, though, I think.  Perhaps I can experiment on a weekend,
when it won't matter if I conk out at 7PM.

> The only way to know for sure on perhaps all of those is a sleep recheck on the
> medication(s) and trial of heated humidifier, and they put wires on the legs to
> check for Restless leg syndrome. If that's the case, a different type of sleep
> medicine is better.

When the did the C-PAP titration study, I had taken Ambien and they were
using the humidifier.  That time, and in the previous study, they did
have me wired to check for RLS.

Personally, I believe that I tighten the muscles in my neck, back & jaw
while asleep, to the point where it may be waking me, but the sleep doc
says the sleep studies don't show that (and would if it were happening).
 In case this occurs to you, yes, I do have a bite guard for night wear
because of tooth-clenching.

The sleep doc said the only thing that looked unusual when they did the
C-PAP titration was abnormally short REM periods, which could just have
been REM rebound.  One of the techs after the first study told me I
seemed to wake up every time just as I was going into REM.  Sigh!

> Do you take both? My brother and many others do, as long as there's no
> contra-indcative reasons.

I don't have a quote handy, but from memory I believe the Sonata/Ambien
combo is a no-no.

>>Digression that may not make sense outside the U.S.:  A friend loaned me
>>her stuffed-animal Serta Counting Sheep when I went to the sleep clinic.
>
> :-) not aware of what that is but I'm certainly aware of being one of the sheep.

It started as a mattress commercial with *excessively* cute claymation
sheep fussing that the mattresses were putting them out of work as
"counting sheep".  For visual, see:

https://secure.serta.com/Merchant2/merchant.mvc?Screen=CTGY&Category_Code=TH

> One night, the staff ordered out pizza for some of us who were at the end of the
> line on the preparation (wires etc)
> Yummy, but I still can never sleep good in those places, I prefer my own bed.

The first sleep study nightI slept extraordinarily poorly at the clinic
-- unlike usual, had trouble getting to sleep.  Every time I started to
drift off, I'd think "I wonder what my brain waves look like now" or
somesuch, and wake myself up again <g>!  But for the C-PAP titration,
the combo of my first Ambien & my first night on the C-PAP overcame that
impulse.  Pity the effect didn't last!

Thanks, J --

Ann T.
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J - 16 Jan 2004 22:20 GMT
Hi Ann,
I have an awful time inserting text.  I will check out the web page you posted. (thank
you)

No, do not split the Ambien and take it earlier or you will conk out.
http://www.rxlist.com/cgi/generic/zolpid_ids.htm
It's a sedative/hypnotic. I've never tried it myself, but it says there
"Zolpidem tartrate has been shown to decrease sleep latency and increase the duration
of sleep for up to 5 weeks in controlled clinical studies " (whatever that means).
And I don't even know if that type of tablet is scorable/splittable or should not be,
so please don't try.
And no, probably should not be combined with Sonata.

The other Elavil/amitriptyline is supposed to be known to increase REM sleep stages.
I do not think it can be combined with Ambien, but perhaps with Sonata.
http://www.rxlist.com/cgi/generic/amitrip.htm

Gee, I'll have to think about all this, just firing this off (for now) before you leave
(maybe) for the weekend to not split the Ambien.
J
A. P. Thorsen - 16 Jan 2004 22:32 GMT
> Gee, I'll have to think about all this, just firing this off (for now) before you leave
> (maybe) for the weekend to not split the Ambien.

Got it!  Thanks; your information & experiences are helpful!

I know this probabaly really isn't a big enough deal for me to be
bugging ASCB about, but I'm not sure where else to turn for independent
ideas about what to suggest to my docs.

Appreciatively,

Ann T.
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J - 18 Jan 2004 00:58 GMT
> Personally, I believe that I tighten the muscles in my neck, back & jaw
> while asleep, to the point where it may be waking me, but the sleep doc
[quoted text clipped - 6 lines]
> been REM rebound.  One of the techs after the first study told me I
> seemed to wake up every time just as I was going into REM.  Sigh!

Well you seem to have covered a lot, but we still don't know what's causing these
wakeups.
titration set too high?

I know when I tried CPAP, the machine does not breathe with me, but against me.
It was breathing in, and I wasn't finished breathing out (or vice versa).
Same happened to my brother, so he had to go to BiPap, the breathing in rate can be set
differently to the breathing out rate. Despite that he was still waking up.  Air
leakage around the mask, he tried duct taping and finally changed types of masks.
The above also can cause neck etc discomfort. I believe there's a home oxymeter to
measure oxygen levels at home, instead of having to go in for the test.

Other causes of wakeups:
anxiety which you mentioned
partner with sleep disorder - boot him out or send him for sleep test
noises
dreams (some meds can cause that)

he (brother) sleeps on his side
sometimes I use a bone-shaped pillow under my neck which puts my head at a slight
backward slant, therby opening up the airway more. (sleeping on the back).. (see your
neck discomfort above)

poor sleep hygiene:
baths or showers too close to bedtime can wake a person up
exercise (other than sex) too close to bedtime can wake a person up
caffeine containing products  - ditto
things on the mind  - I have a routine where I get them off my mind in the evening and
onto paper if they're unresolved.
Massage (neck area - tension) and deep breathing relaxation while watching TV or before
getting into bed.
Turn computer and phone off.
TV lulls me to sleep especially if it's boring. (some are the reverse)..ditto for
books.
turn brain (and worries and any discussion that stimulates your brain) off - you want a
brain and physcial winddown time leading up to bedtime. (if that includes someone
calling you with their problems late at night, don't answer the phone..or a partner
talking about an exciting project, tune him out :-)

Some people have sucess with zoloft.
Wellbutrin wakes me up (no sleepy)
I forgot to mention that the tricyclics can sometimes cause weight gain (in some
persons), but they're the best meds to achieve longterm sleep (REM), but sometimes
difficult to tolerate in us oldies. Oh, if you have hot flashes, then perhaps Elavil is
not the one, because it can have heat intolerance associated with it).

Whew ! hope I haven't forgotten anything.
J
A. P. Thorsen - 19 Jan 2004 13:34 GMT
<much helpful information about sleep problems>

J, thank you so much for taking the time to pull all this together.
Some good food for thought for me here; I'll be taking time to review,
research, and mull it over.

Appreciatively,

Ann T.
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J - 18 Jan 2004 00:36 GMT
> Digression that may not make sense outside the U.S.:  A friend loaned me
> her stuffed-animal Serta Counting Sheep when I went to the sleep clinic.
[quoted text clipped - 3 lines]
> getting into the shower, etc., and was able to return the stuffed animal
> to my friend with a captioned photo scrapbook . . .

ROTFLMAO
I thought you were referring to the patients filling out paperwork etc.(and I
wondered if you'd asked their permission to take their photos first).
Duh me !
:-)
J
Tim Jackson - 16 Jan 2004 21:11 GMT
> I may've mentioned that I've been wrangling with sleep interruption
> since BC treatment started.  I go to sleep easily, but wake up
[quoted text clipped - 3 lines]
> speculation based on timing of the problem starting, I believe).  My
> oncologist said "Nope".

What reasons does your oncologist give for being so hard against a three
week break in Tamoxifen.  I thought Tamoxifen mainly worked by holding
cancer growth in check.  How far could a cancer grow in three weeks?  I
don't see why a short break should be seen as such a disaster.

> So, they pow-wowed, and the latest is that the oncologist wanted me to
> try switching to Arimidex.
[quoted text clipped - 4 lines]
>
> I thought aromatase inhibitors were only for the menopausal

Indeed.  Why not get another FSH test to see if it's gone pedal to the metal
yet?

> Since this group usually seems more tuned in that most medical
> professionals, I thought I'd run the whole mess by y'all & see if any
> one has any thoughts on the Sleep/Arimidex/Tamoxifen/Menopause subject.

I seem to get bouncy sleep like that when I'm bored, or if I drink too much
beer, but I suspect you are right that this is a combination of apnea and
hormones.

Tim
A. P. Thorsen - 16 Jan 2004 21:56 GMT
>>The sleep doc wanted me to try going off Tamoxifen for 3 weeks (pure
>>speculation based on timing of the problem starting, I believe).  My
>>oncologist said "Nope".
>
> What reasons does your oncologist give for being so hard against a three
> week break in Tamoxifen.

I haven't talked to the onco doc directly yet (working through the nurse
so far), but I may be partly to blame for this . . . I have a low level
of enthusiasm for going off the Tam even temporarily, and communicated
that.  It's probably paranoia, but I'd rather push for a different
solution.  If going off Tam worked, where would that leave me?  Off
permanently is Not Worth It, in my book, desperate as I am to resolve
the sleep problems.  I've got two years yet to go for the standard course.

>>I thought aromatase inhibitors were only for the menopausal
>
> Indeed.  Why not get another FSH test to see if it's gone pedal to the metal
> yet?

I'm rather hoping that will be the outcome, unless the onco gives me
some rational sounding thinking about the aromatase inhibitor mitigating
the effect of going off Tam temporarily, or something.

> I seem to get bouncy sleep like that when I'm bored, or if I drink too much
> beer, but I suspect you are right that this is a combination of apnea and
> hormones.

Indeed -- 3 years would be a long time for me to have been bored or
beer-y (especially when I've drunk perhaps 1 or two in the whole
period)!  The apnea's theoretically treated now, though, so that should
be out of the picture.

For us middle-aged women, as for adolescents of both genders, it seems
like everything eventually boils down to hormones!  (OT:  A masters'
women's rowing team in Boston is called the "Hot Flashes" . . . they
have Really Swell black t-shirts with a neon-bright team name on the
front, and "Never underestimate the power of hormones." on the back.)

Thanks, Tim -- you seem to be thinking along the same lines I am, which
is reassuring.

Ann T.
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Tim Jackson - 17 Jan 2004 00:04 GMT
> > For us middle-aged women, as for adolescents of both genders, it seems
> like everything eventually boils down to hormones!

I have yet to reach an age when it doesn't.
I find the world makes a lot more sense if you assume everyone is slave to
hormones.

Tim
 
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