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Medical Forum / Diseases and Disorders / Breast Cancer / January 2004New Support of Explanation of Breast Cancer: Smoking and Breast Cancer
New Support of Explanation of Breast Cancer Copyright 2003, James Michael Howard, Fayetteville, Arkansas, U.S.A. Two articles add support to my hypothesis regarding testosterone in women and breast cancer. (Find "An Explanation of Cancer and the Increase in Cancer," about the middle of www.anthropogeny.com/physiology.html .) That is, I suggest increased testosterone is involved in triggering cancer, including female breast cancer. In the first article from the January, 2004, Journal of the National Cancer Institute, U.S.A., you will read the finding that "active smoking may play a role in breast cancer etiology." The second article demonstrates that smoking in women is connected with increased testosterone. "Current smokers had the highest testosterone concentrations with decreasing values in former and nonsmokers (p = 0.0001)." Again, I suggest this adds support to my explanation of the mechanism of cancer and I invite you read my article. jmhoward wrote: << I suggest increased testosterone is involved in triggering cancer, including female breast cancer. In the first article from the January, 2004, Journal of the National Cancer Institute, >> I won't argue that there may be a connection between testosterone levels and its association with breast cancer, and I don't have any information re. women, smoking, and testosterone levels so can't really comment about that. However, I have never smoked and avoid being around those that do (which is not hard to do in California), but I still got breast cancer and have had higher than normal testosterone levels. I am not sure if other females in my family have or had the same, but I suspect that in my case it may be genetic. I believe women who have polycystic ovaries also have higher than normal testosterone levels and also have an increased risk of developing breast cancer. Again, I don't know if female smokers do or don't have higher estrogen levels but suspect that even if there was some increase that it is not across the board. In addition not all female smokers get breast cancer. I am thinking of my husband's aunt who smoked heavily. She did develp cancer--pancreatic cancer--but not until the age of 85. >jmhoward wrote: << I suggest >increased testosterone is involved in triggering cancer, including female [quoted text clipped - 16 lines] >husband's aunt who smoked heavily. She did develp cancer--pancreatic >cancer--but not until the age of 85. Thank you for your response. In my original post to this newsgroup, I included a working url for my explanation in detail. I invite you to go there to read my article. All supporting citations are there. However, since you responded, I will answer your statements / questions. In 2002, the Journal of the National Cancer Institute U.S.A. said that "testosterone might be more strongly associated with [breast cancer] risk than estradiol." (citation at page) Also on my page, I suggest that my mechanism triggers "oncogenes," cancer genes. One does not have to smoke for this mechanism to trigger breast cancer oncogenes, one has to have high testosterone and low DHEA, with low DHEA being the key. (In fact the 2004 JNCI article that caused me to repost my explanation of breast and smoking found that second hand smoke has no relationship with breast cancer, only smoking in women.) Since smoking does increase testosterone in women, the smoking is connected with breast cancer in women who have the oncogenes. Yes, increased levels of free testosterone are part of pos and, if a woman's family has breast cancer oncogenes, there is increased risk of breast cancer in pos. Yes, not all female smokers get breast cancer; they are more likely if breast cancer genes are in their families just like in pos. My mechanism also explains the increased cancer of old age as due to low DHEA. James Michael Howard jm howard << In 2002, the Journal of the National Cancer Institute U.S.A. said that "testosterone might be more strongly associated with [breast cancer] risk than estradiol." >> I do not disagree that testosterone may be more associated with breast cancer than other hormones, although not necessarily estradiol. What about estrogen? Anyway, I did ask that question at the time of my dx or at least at some point when my testosterone levels were higher. I was not given an answer. I then tried to research it. I was quite surprised to learn that many knew that higher levels of testosterone were associated with an increased risk of breast cancer and that many older women who got breast cancer had higher levels of such. However, there has been almost no medical research in this area? Why? Is it because of the social implications of testosterone and that, at least in the past, science research and related funding has had a male dominated field? The effects of smoking may be a trigger for some and is not as far-fetched as the suggestion that someone recently made that breast cancer is due to the wearing of high heeled shoes, but it is not a definative trigger. Not all women with breast cancer, even ER+ breast cancer, have higher levels of testosteron, and neither do all female smokers have higher levels of testosterone. And I am also quite sure that some smokers who have higher levels of testosterone don't get breast cancer. That doesn't mean that testosterone levels aren't involved for some, though. What does pos mean? >jm howard << In 2002, the Journal of the National >Cancer Institute U.S.A. said that "testosterone might be more strongly [quoted text clipped - 19 lines] >testosterone levels aren't involved for some, though. >What does pos mean? Estradiol is a one form of "female hormone" in the category "estrogen." I cannot explain why your physician was rude to you. It is my idea that estradiol increases cancer risk in the same manner as does testosterone. You will have to read the article to understand the mechanism. Therefore, not all women with breast cancer will exhibit higher testosterone levels. Again, the research reported: "Our study provides evidence that active smoking may play a role in breast cancer etiology ..." (Journal of the National Cancer Institute, Vol. 96, No. 1, 29-37, January 7, 2004). You may choose to believe the findings or not. One has to have an oncogene that may be triggered by this mechanism to begin breast cancer. Therefore, smoking, smoking induced increases in testosterone, or simply having high testosterone does not mean one will have breast cancer. jmhoward wrote: << Estradiol is a one form of "female hormone" in the category "estrogen." I cannot explain why your physician was rude to you. It is my idea that estradiol increases cancer risk in the same manner as does testosterone. >> Huh??? I never said my physician was rude to me. I am not sure where or how you came up with that. I did imply that my physician had no understanding of the role of testosterone and breast cancer. That area does not appear to have been researched much. My thoughts are that it may be a sensitive area of research because of associations re. 'testosterone' in a male-dominated field. I<< Our study provides evidence that active smoking may play a role in breast cancer etiology ..." (Journal of the National Cancer Institute, Vol. 96, No. 1, 29-37, January 7, 2004). >> I don't disagree at all with the above. However, not all smokers develop higher than normal testosterone levels, and as we both agree, not all women with high levels of testosterone, who do develop cancer, with smokers. There appears to be a very strong causal relationship between hormonal breast cancer and higher than normal levels of testosterone in women, irregardless of the cause. Again, I was quite surprised myself to learn that this area was not better researched. And although estradiol and estrogen are hormonal agents they are the same and do not react in the same way to intervention. |
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