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Medical Forum / Diseases and Disorders / Breast Cancer / January 2004Tamoxifen effects?
My wife has finished with A&C, Taxol and Herceptin and the next step it seems will be tamoxifen. What side effects should she expect? TIA > My wife has finished with A&C, Taxol and Herceptin and the next step it > seems will be tamoxifen. What side effects should she expect? My attitude to this is that if you're told to expect side effects you'll probably get them. Why not just take the stuff and report anything which might be related to the practitioner? There are many side effects to every drug and most are very slight. Few people suffer all of them, most people I reckon have none. I had no side effects from what I took. Mary > TIA >My wife has finished with A&C, Taxol and Herceptin and the next step it >seems will be tamoxifen. What side effects should she expect? She should expect no side effects - if she expects to have trouble she's probably more likely to get it. I've been on it for 2 years now - still waiting for the first side effect. Some women DO have side effects, but unless there's some reason to expect your wife will have some side effect triggered by the drug, why not just go into it with an open mind and assume she'll do perfectly fine??? Sue - DivaofDVC aka WDW1972 DVC '97 OKW, Beach Club, Vero Beach, & Hilton Head >>My wife has finished with A&C, Taxol and Herceptin and the next step it >>seems will be tamoxifen. What side effects should she expect? > She should expect no side effects . . . > Some women DO have side effects, but unless > there's some reason to expect your wife will have some side effect triggered by > the drug, why not just go into it with an open mind and assume she'll do > perfectly fine??? I agree with that sentiment . . . but truth in advertising compels me to admit that I, and a percentage of others I've talked with, do experience hot flashes from Tamoxifen. In most, these can be alleviated with vitamins or, if necessary, stronger drugs; and for most, they seem to subside over time on their own. Not a biggie in my world, especially in light of Tamoxifen's benefits. Ann T. Remove 'dontsendspam' from I was not told of any side effects but did gain 30 lbs and have horrid hot flashes. After checking with my doctor I was told that " some" people have these problems. I was one of the "lucky" ones maybe your wife will not have any side effects at all. Barbara > >>My wife has finished with A&C, Taxol and Herceptin and the next step it > >>seems will be tamoxifen. What side effects should she expect? [quoted text clipped - 15 lines] > Ann T. > Remove 'dontsendspam' from Since we are on the subject of Tamoxifen and I, too, will be starting it in about 2 weeks, can anyone answer a question for me which my Onc could not. I thought I had read someplace that on one of these type drugs, either Tamoxifen or Arimidex that one was not supposed to take anti-depressants. I use Elavil and Remeron together at night for sleep and wonder if there will be a problem with continuing them the 5 years I will be on Tamoxifen? My Onc says he never heard of any interactions between the drugs. Do any of you know anything about this? The Elavil may also help with any hot flashes I may get and other problems so I would not want to have to stop it. Thanks for any info you may have on this. Bea > Since we are on the subject of Tamoxifen and I, too, will be starting it > in about 2 weeks, can anyone answer a question for me which my Onc could [quoted text clipped - 9 lines] > > Bea I think you are referring to this: A study of 12 women were given paroxetine, a "selective serotonin reuptake inhibitor" (SSRI) type of anti-depressant used to control hot flushes, over four weeks and it was found that this reduced the activity of some enzymes involved in the active pathway through which Tamoxifen works (J National Cancer Institute 3 Dec 2003) This is not proof that there is a problem but it is evidence that there is an interaction between these types of drugs which would bear investigating. The authors of the study recommended that no changes in prescribing were justified at this time. Tim Jackson >A study of 12 women were given paroxetine, a > "selective serotonin reuptake inhibitor" (SSRI) > type of anti-depressant used to control hot > flushes, Yes, Tim, that was it. Thank you so much! I found the report on it on another bc website and I don't think Elavil is in that class of anti-depressants (or I hope not!). I also tried to do a "drug interaction" thing on a pharmacy page to see what happened when I put in Elavil and Tamoxifen and it did not give me any precautions or interactions. So...I guess until further studies come forth, I am ok with the two drugs. Bea > >A study of 12 women were given paroxetine, a > > "selective serotonin reuptake inhibitor" (SSRI) [quoted text clipped - 8 lines] > interactions. So...I guess until further studies come forth, I am ok > with the two drugs. Something so vague and preliminary wouldn't be on pharmacy interaction lists (yet). I don't know which drugs fall into this class, the person to ask is the doctor who prescribed the drugs - show him the article. Yes, carry on, I don't think that even if the interaction they found has an effect on cancer protection, that it will reduce the effectiveness of Tamoxifen by much. Tim Jackson >Something so vague and preliminary wouldn't > be on pharmacy interaction lists (yet). I don't > know which drugs fall into this class, the > person to ask is the doctor who prescribed > the drugs - show him the article. >Tim Thanks for the additional info, Tim. BTW, I did ask my Oncologist who prescribed the Tamoxifen and he said to ask my pharmacist because he was not aware of such a problem. I'll do that when I go get it filled next week. I notice when I ask such questions of my phamacist, all he/she does is pull up an internet site and see what it says. If what you post is correct, and I have no reason to doubt you, then they won't be able to find out either. Either way, I need to try the Tamoxifen and I need my other meds so we'll just see what happens. Thanks! Bea I noticed in your address that you're from Vero Beach. I live in Vero Beach too! Small world. I used to have Webtv and read this discussion board all of the time. I gave the Webtv to my Dad (I'm at his house visiting) and got a computer. I wonder if there's anyway I can still correspond with this discussion group. Maybe the moderator can e-mail me and let me know. alexiskrasotkin@hotmail.com By the way, I was diagnosed in April and had a mastectomy, six months of CMF chemo (no lymph node involvement) and have been on Tamoxifen for four months now, with no side effects. >I noticed in your address that you're from Vero > Beach. I live in Vero Beach too! Small world. I > used to have Webtv and read this discussion > board all of the time. I gave the Webtv to my > Dad - snip Are you talking to me (Bea??) Where did you get the idea I was from Vero Beach? I don't think I mentioned where I was from but it's not Vero Beach. I guess that means we are only related now by our bc problems and you were a former Webtver.<g You do know that you can still access this discussion group through Google too, don't you. Just type in "alt.support.cancer.breast" and it should bring it up. BTW, thanks for sharing the info that you are doing ok on the Tamoxifen. I need all the "thumbs up" I can get since I am really nervous about starting this drug. (Especially now since our dear Su-Texas is stating something about it being an anti-fungal.<g) Bea > BTW, thanks for sharing the info that you are doing ok on the Tamoxifen. > I need all the "thumbs up" I can get since I am really nervous about > starting this drug. (Especially now since our dear Su-Texas is stating > something about it being an anti-fungal.<g) I've said it lots of timed but am very happy to repeat it ad nauseam. I was on a research programme for five years and was taking either tamoxifen or arimidex. I had no side effects of any kind - except that it seems to be harder to keep my weight down since I stopped. That might or might not be related, there are always other influences in ours lives. My thumbs are well up! Mary > Bea |
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