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Medical Forum / Diseases and Disorders / Breast Cancer / December 2003

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Lupron Side Effects?

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passedpast - 18 Dec 2003 18:51 GMT
My wife has stage 4 breast to bone to liver ca.  She was informed that she
received by error 2 three month Lupron shots in consecutive months.  She is
concerned about the side effects, although her oncologist told her it should
be minimum.  Does anyone have any info on this or a website I could refer
to?  Thanks.
allan grossman - 19 Dec 2003 00:35 GMT
>My wife has stage 4 breast to bone to liver ca.  She was informed that she
>received by error 2 three month Lupron shots in consecutive months.  She is
>concerned about the side effects, although her oncologist told her it should
>be minimum.  Does anyone have any info on this or a website I could refer
>to?  Thanks.

Here's one -

http://www.endofacts.com/expect/productinfo.htm

Hope this helps -
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Kaye301 - 21 Dec 2003 16:37 GMT
One of our daughters received monthly Luprpn shots for 2 years, from the ages
of 10 to 12.  The only side effect that she had was related to the reduced
estrogen levels which was the why she was given the Lupron--to delay onset of
menstruation because of her age and short stature in comarisone to other family
members, and family risk of breast cancer.  
Yhe side effect she had was one that she had first experienced about 3.5 to 4
years before she started the Lupron-both motor and vocal tics which began at
the age of 6 yrs.  3 mos.  which worsened to the point at which we felt
medication was indicated when she reached the age of 7 rs. 10 mos.  The
medication (nortriptyline) worked within 10 to 14 days--all tics and related
behaviors were gone.  (By the way, Nortriptyline was not developed or
researched for this condition--its positive effects were discovered
accidentally--and if given at low dosages was found to be one of the best of
medications for such with least side effects).  Anyway, after being on the
medication for 10 mos, at a time when she seemed to no longer need it, we
decided to take her off of the Nortriptyline for the summer wich she remained
off it for 18 mos.  However, during this time she began early pubertal
development (which has been seen in both sides of family for some).  Because of
the family hx of breast cancer (in addition to her short stature compared to
her older sisters and earlier rate of development compared to them as well) she
started Lupron injections the month of her 10th birthday.  Within the first
month after she had it the tics returned at a level they had been when they
were at their worst.  I felt quite 'guilty' even allowing her to take the
Lupron.  We went back to her pediatrician and endocrinologist.  She asked for
the medication for the tics because she said she "can't stop doing them."   She
went back on the Nortriptyline and again within about 10 to 14 days the tics
were gone.
The dr's used her case as anecdotal research--that estrogen levels have a
protective effect against tics and related obsessive compulsive disorders in
those who are predisposed.
The Lupron did not cause the tic disorder.   It was something that had
developed 4 years earlier.  The reduced estrogen levels brought it back.   She
took additional medication to control that without a problem.
She stopped the Lupron at the age of 12.  The estrogen levels slowly returned,
and she did not get her period until she was 13.  She has not had any problem
since.  She stopped the Nortrptyline at a time she told us she was ready--12
years 9 mos.  She had a slight rebound effect for about 4 to 6 weeks, but no
problems since.
She currently is doing great--just finished her freshman year at a private
university (to which she had earned an academic scholarship), and is and has
always done well socially, too.  She is in a sorority, has tons of friends,
continues to do well, and 'loves' her lifee.  We feel that the medication
interventions--including the Lupron--greatly contributed to her
success--enabled her to be her best 'self.'
Again, the Lupron did not cause the tic disorder.  That was something she
developed or was first seen at the age of 6 (and runs in the family--my
husband's first cousin, my first cousin, my sister (although she denied ot),
children of my mom's first cousins, also), and I had mild tics as a child.  The
reduced estrogen levels may bring it back in those who are predisposed.  (I
have not had any difficulty with such since chemmo, having my ovaries out, or
being on Arimidex).

<< My wife has stage 4 breast to bone to liver ca.  She was informed that she
received by error 2 three month Lupron shots in consecutive months.  She is
concerned about the side effects, although her oncologist told her it should
be minimum.  Does anyone have any info on this or a website I could refer
to?  Thanks.
Kaye301 - 21 Dec 2003 20:48 GMT
oops, sorry for all the typos--was in process of proof reading when former post
was accidentally sent--and that is because my right hand/arm has lymphedema
bandage  same side as mouse
 
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