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Medical Forum / Diseases and Disorders / Breast Cancer / December 2003

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advexcin Proteen-P53

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gabnet' - 04 Dec 2003 02:56 GMT
Hello Everyone:

Today, my husband while listening to Finacial netwoek news heard about a
new drug for cancer.  It is called advexcin proteen-p53.  Has anyone
hard anything about this?

Thanks.
Signature

Hugs,

Laura K.*
I'm out of estrogen and I have a gun!

Tim Jackson - 04 Dec 2003 09:13 GMT
Advexin is an engineered virus which delivers a gene for the P53 protein
which is suppresses growth in many cancers and is the target of much
research.  P53 causes cells who's DNA is damaged to hibernate or die.  One
of the mutations required for cancers to grow is destruction of subversion
of the cells normal p53 mechanism.

Advexin is currently in phase III trials for head and neck cancer.

There was a phase II trial this year at MD Anderson for locally advanced
breast cancer where this drug was added to a neo-adjuvant (pre-surgery)
chemotherapy regime.  The results so far appear encouraging.

Tim Jackson

> Hello Everyone:
>
[quoted text clipped - 8 lines]
> Laura K.*
> I'm out of estrogen and I have a gun!
*shaz^ - 05 Dec 2003 17:16 GMT
Hi Laura,
I don't know if this new drug for cancer you have heard of, is the same as
the one which I have been told about, but this does sound very encouraging.
Lets hope the research pays off huh?
I was told by a friend who lives in the U.S, that there is some kind of
trials going on over there, which have been very encouraging with regards to
tests that have been done so far on lab rats. It does sound to be something
very similar to what you and subsequently Tim, have been describing.
Let's all hope that these tests go on to be as successful in humans?

Take care,

Shaz x
> Hello Everyone:
>
[quoted text clipped - 3 lines]
>
> Thanks.
 
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