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Medical Forum / Diseases and Disorders / Breast Cancer / December 2003

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Cancer Gone, Then Heart Failure?

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su-texas@webtv.net - 23 Nov 2003 15:55 GMT
Several people have told me, that their relatives died from heart
failure (although no heart problems had been previously noticed or
diagnosed), ... a short time (weeks or months?) after their advanced
cancer had suddenly & mysteriously cleared-up/disappeared.

???

Susan, Su_Texas  my opinions

PS  One of the people who told me this, appeared to be a wealthy &
powerful woman.  [I met her at a hospital cafeteria in Shreveport, & she
told me about her brother's dying this way.]  

Medically, everything possible had been done for him (because they could
afford it), ... but he was in hospital & appeared to be dying from the
cancer.  

Then, all trace of the cancer was gone.  [I believe the cancer might
have been partly esophagial (sp?).]

They (he & relatives) celebrated his sudden & unexpected recovery from
cancer, & his return to good/better health.  Shortly after that, he died
from heart failure.

Since then, a few other people have told me similar stories.

------------

I do know that the cancer treatments can damage the heart some (which
could partly explain the heart failure), ... but that doesn't explain
the sudden disappearance of advanced cancer, right before heart failure.
Kaye301 - 23 Nov 2003 16:28 GMT
Su wrote << I do know that the cancer treatments can damage the heart some
(which
could partly explain the heart failure), ... but that doesn't explain
the sudden disappearance of advanced cancer, right before heart failure.>>

It's not quite the same...but...my husband's aunt was dx'd with congestive
heart failure (which cleared up) before her cancer dx.   (She was a heavy
smoker at the time (and may still smoke).  She was dx'd with stage IV breast
cancer 5 years ago--at the age of 80--with mets to her abdomen, uterus, colon,
and somewhere else (can't recall).  She opted for a lumpectomy and radiation
based on what she felt would impact the quality of her life.  She was a former
nursing professor who was widowed.  Anyway, after initial treatment they redid
the scans and found no cancer.  She refused to believe it--and basically sat
around waiting to die.  I know I have told the story here before--although had
goofed on her age--I thought she was in her 70's.  Anyway, her daughter with
whom she moved in, told her--'look ma, you're gonna die--but its not gonna be
from cancer.'  That made her re-think things and her attitude improved.
Anyway, she is now 85--and there is no sign of cancer.   She did have a set
back with congestive heart failure this past summer and almost didn't make it.
She rallied through.  I talked with her recently--I wish my memory was as good
as hers.  She is also a diabetic now, and I think she is on insulin.   (She
developed diabetes somewhere between 10 and 20 years ago, I think).  I thought
the insulin might be helping with the cancer.  Anyway, she does have congestive
heart failure--but had it before the cancer dx--and did go into spontaneous
remission.   I had thought that they might have mixed up the films--but the dr.
showed them to her and her daughter and son-in-law.  All are amazed at how well
she has done.  
madiba - 23 Nov 2003 19:03 GMT
> Several people have told me, that their relatives died from heart
> failure (although no heart problems had been previously noticed or
> diagnosed), ... a short time (weeks or months?) after their advanced
> cancer had suddenly & mysteriously cleared-up/disappeared.
Adriamycin/Doxorubicin  is cardiotoxic and is extensively used by
oncologists, so its not surprising that heart failure can occur. Whether
the patients were 'cured' or not is hard to tell as they didn't live
long enough for serial documentation. You could say they were in
remission at the time of death..
Here's a list of the 'approved' malignancies for Adriamycin in Canada:
Acute lymphocytic leukemia, Acute myeloblastic leukemia, Bladder cancer,
Breast cancer, Endometrial cancer, Gastric cancer, Head and neck cancer
- squamous cell, Hodgkin's disease, Lung cancer - non-small cell,
Neuroblastoma, Non-Hodgkin's lymphoma, Osteogenic sarcoma, Ovarian
cancer, Sarcoma - soft tissue, Testicular cancer, Thyroid cancer, Wilms
tumour.
Other uses include:
Adrenocortical cancer, Carcinoid syndrome (small bowel) Ewing's sarcoma
Gynecological sarcoma Hepatic cancer Islet cell cancer Multiple myeloma
Pancreatic cancer Prostate cancer Retinoblastoma Rhabdomyosarcoma

Signature

madiba

su-texas@webtv.net - 23 Nov 2003 20:52 GMT
Adriamycin/Doxorubicin is cardiotoxic and is extensively used by
oncologists, so its not surprising that heart failure can occur.

Whether the patients were 'cured' or not is hard to tell as they didn't
live long enough for serial documentation.

You could say they were in remission at the time of death.

=========

According to his sister, her brother had cancer treatments earlier
[maybe only radiation (?), the best I can remember today], ... but the
cancer hadn't responded to this & was progressing.  He was in agony.
[The cancer was advanced when it was found, so they gave him little
hope.]

Later, he was in the hospital (& expected to die soon), when the cancer
(which had been confirmed by testing) suddenly disappeared.  There was
no trace of it.  And he was pain-free.

He recuperated some & was expected to go home, when he suddenly died of
heart failure.

Several people have told me similar stories, of people about to die from
cancer, who've gone into spontaneous remission, ... only to die a short
while later, of heart failure.

Since these are people I met in passing, I can't go back & question them
for more details.

Susan, Su_Texas  my opinions

PS  If this story is true, then somewhere in this mix might be some
answers in how to beat cancer, how to cause spontaneous remission, ...
but to do it in safer ways, which won't cause heart failure.
marvin - 24 Nov 2003 16:17 GMT
> Adriamycin/Doxorubicin is cardiotoxic and is extensively used by
> oncologists, so its not surprising that heart failure can occur.
[quoted text clipped - 31 lines]
> answers in how to beat cancer, how to cause spontaneous remission, ...
> but to do it in safer ways, which won't cause heart failure.
marvin - 24 Nov 2003 16:19 GMT
> Adriamycin/Doxorubicin is cardiotoxic and is extensively used by
> oncologists, so its not surprising that heart failure can occur.
[quoted text clipped - 31 lines]
> answers in how to beat cancer, how to cause spontaneous remission, ...
> but to do it in safer ways, which won't cause heart failure.

i've got no cancer symptoms now but i've got attrial fibrillation from the
chemo - symptoms - fluttering heart and swollen ankles ... taking digoxin
and warfarin ...this has controlled my heart and taken away my swollen
ankles.
madiba - 24 Nov 2003 16:34 GMT
> PS  If this story is true, then somewhere in this mix might be some
> answers in how to beat cancer, how to cause spontaneous remission, ... but
> to do it in safer ways, which won't cause heart failure.
So what you're insinuating is that there may be some treatment for heart
failure which is getting rid of the cancer..  or the the heart failure
itself (depriving the tumor of O2 or the injured heart sending out
hormones which shink the tumors?) is doing the job.
Interesting, but unlikely.
The more likely explanation is that all the attention is turned to
treating the heart failure, in the mean time the tumor shinks, and all
of a sudden someone notices that its gone.

Signature

madiba

marvin - 25 Nov 2003 01:06 GMT
> > PS  If this story is true, then somewhere in this mix might be some
> > answers in how to beat cancer, how to cause spontaneous remission, ... but
[quoted text clipped - 7 lines]
> treating the heart failure, in the mean time the tumor shinks, and all
> of a sudden someone notices that its gone.

huh - no - just saying these stoopid oncologists can kill ya.
madiba - 25 Nov 2003 15:58 GMT
> > > PS  If this story is true, then somewhere in this mix might be some
> > > answers in how to beat cancer, how to cause spontaneous remission, ...
[quoted text clipped - 10 lines]
>
> huh - no - just saying these stoopid oncologists can kill ya.
Stoopid is as stoopid does, Marvin. I was replying to Su_Texas..

Signature

madiba

*shaz^ - 26 Nov 2003 18:53 GMT
Yikes! I've had 2 courses of A/C chemo, 1 was for a Wilms tumour i had as a
child and the other I finished earlier this year, which was for stage 2 b.c.
So does this mean that i'm a candidate for heart failure sometime soon, or
in the near future??????

I'm worried now!

Shaz x

> > Several people have told me, that their relatives died from heart
> > failure (although no heart problems had been previously noticed or
[quoted text clipped - 16 lines]
> Gynecological sarcoma Hepatic cancer Islet cell cancer Multiple myeloma
> Pancreatic cancer Prostate cancer Retinoblastoma Rhabdomyosarcoma
madiba - 29 Nov 2003 16:30 GMT
> Yikes! I've had 2 courses of A/C chemo, 1 was for a Wilms tumour i had as a
> child and the other I finished earlier this year, which was for stage 2 b.c.
> So does this mean that i'm a candidate for heart failure sometime soon, or
> in the near future??????
>
> I'm worried now!
If you've been able to play sport etc since the Wilms treatment or since
the BC treatment without getting breathless and your ankles aren't
swollen you're ok.  The frequency of heart failure is dose-dependent and
considered an acceptable risk for the excellent tumoricidal effect it
brings. If you received the newer version of adriamycin/doxorubicin
(epirubicin) then the risk is even smaller and ranges from 1-27%,
depending on the cumulative dose.

Signature

madiba

Kaye301 - 29 Nov 2003 17:40 GMT
Madiba wrote: << If you received the newer version of adriamycin/doxorubicin
(epirubicin) then the risk is even smaller and ranges from 1-27%,
depending on the cumulative dose.>>

I began my research before I started chemo and read of the advantages of
epirubicin over adriamycin re. cardiac risk.  And since I was born with a
congenital heart condition (I know, something else 'wrong' with me, I am a
walking disaster--but for the most part a good-working one), I asked if I could
have epirubicin instead.  I was told that it wasn't used here (the states)
except in very unusual circumstances.  From what I gather it is more political
than anything else.  For whatever reason, adriamycin was the drug that came
aboard first and somehow gained a foothold in standard protocol.  
And in regard to standard protocol of the 4 AC regimen that was adopted--not
all approved.  It was adopted out of convenience and compromise based on the
fact that  6 FAC was better than 6 CMF.   4 AC was never evaluated against 6
FAC or 6 CMF directly.  I think I got that right--have that listed somewhere in
my files.   The decision to go that route was not based on valid testing; yet,
in order to receive a new treatment, it cannot become standard without several
phases of trials.  There is no consistency in how this is done, let alone
fairness when it comes to saving lives.  We, the U.S., used to be the
forerunners or models for medical gains and research--at least for awhile--and
for the 'right' reasons.  Now, competition and profit have taken the lead.  I
don't think it is the fault of the dr. or researcher.  They went into this for
the 'right' reasons but because they were focused on doing their job for
altruistic reasons, they became easy prey for the profit-oriented "middle-man."
I am sure, there were a few or maybe some (dr's and researchers) who sold out
and then convinced many of their gullible colleagues, who were too busy doing
their jobs and not becoming involved, to follow-suit--often by default.  It
happened in other health-care fields, too.
Most recently I recall glancing at one of my husband's dental
journals--headlines were how to increase one's earnings by 200 to 300 thousand
dollars.  The article talked about how to become a good sales
person--convincing patients about services, which may weaken their tooth/teeth
that they do not or do not yet need.  When my husband first became a dentist,
they could not join the ADA (Amer.  Dental Society) if they did any
advertising.  That changed and the rest is history.  As I mentioned, I married
a guy who went into the field for the 'right' reasons.  He was carefully
selected by the former dentist whose practice he bought for those very reasons.
He is called upon by attorneys today to be an expert witness.  He is
well-respected by his patients and specialists (to whom he still sends
appropriate referrals rather than doing not needed procedures) himself.   He
can do the procedure if needed, and will but only if appropriate.  I don't mean
to give this field a 'bad' name.  There are still plenty of dentists around who
do practice old-fashioned dentistry according to the previous protocol that was
considered the ethics of that time.
I am sure there are still dr's around who do the same, too.  I am not sure
where this is going and am beginning to bore myself here--as well as see the
time creeping up on me and need to get ready to go somewhere...so get off my
'soapbox' and end.  Hope all enjoy the day...
*shaz^ - 30 Nov 2003 18:11 GMT
And in regard to standard protocol of the 4 AC regimen that was adopted--not
all approved.  It was adopted out of convenience and compromise based on the
fact that  6 FAC was better than 6 CMF.   4 AC was never evaluated against 6
FAC or 6 CMF directly.

I was also wondering about that, ie the standard protocol of 4 AC, as I was
given 6 doses. I have often wondered why this was. As most people I know
who've had AC chemo, tend to have 4 AC doses and not the 6 that I was given.
Any of you medical boffs got any idea why this was?

Shaz x
bell-lady - 29 Nov 2003 18:59 GMT
I'm curious to hear from a medical person on the '2 treatments of AC" the
poster was given.
I had 12 monthly treatments of AC for lymphoma in 1983. I was told at the
end of that year there could be NO more Adriamycin as I'd had the limit for
my lifetime.

Is it possible to get more if it is needed - I'd mentally written off that
as a possiblity..I'll ask by onc, but what say you all? Some of you are
quite med-wise folks!

Ann in PA
marvin - 02 Dec 2003 12:38 GMT
> > Yikes! I've had 2 courses of A/C chemo, 1 was for a Wilms tumour i had as a
> > child and the other I finished earlier this year, which was for stage 2 b.c.
[quoted text clipped - 9 lines]
> (epirubicin) then the risk is even smaller and ranges from 1-27%,
> depending on the cumulative dose.

that's right - y'r ankles swell terribly- i take digoxin and they don't
swell anymore and it also reduces atrial fibrillation wot i got from
radiation on my spine.

my legs went weak on saturday night and i was sweating and white in the
face - went to the local doc on monday and he had no idea what it was and
gave me more pain tablets - as i was walking to the chemist on my crutches
it all came well again and i returned to perfect health in a few minutes -
must have been a pinched nerve in my spine between my shoulder blades which
i just had the met radiated a couple of months back, eh?
Kaye301 - 02 Dec 2003 18:37 GMT
Marvin wrote: << my legs went weak on saturday night and i was sweating and
white in the
face - went to the local doc on monday and he had no idea what it was and
gave me more pain tablets - as i was walking to the chemist on my crutches
it all came well again and i returned to perfect health in a few minutes -
must have been a pinched nerve in my spine between my shoulder blades which
i just had the met radiated a couple of months back, eh? >>

How frightening!  Sorry, I don't have any answers as to what it may have been
but do think you should consult your treating physician(s) re this incident.  I
am glad that you are okay now.  Take care...
Tim Jackson - 23 Nov 2003 22:47 GMT
> Several people have told me, that their relatives died from heart
> failure (although no heart problems had been previously noticed or
> diagnosed), ... a short time (weeks or months?) after their advanced
> cancer had suddenly & mysteriously cleared-up/disappeared.
>
> ???

Just a thought.  Maybe the incipient circulatory failure starved the cancers
of oxygen/nutrients/etc, killing the cancer just before it killed the
patient.  Maybe the normal symptoms of the heart condition were masked by
cancer/chemo side effects.

Tim
su-texas@webtv.net - 24 Nov 2003 09:43 GMT
Thanks Tim.

Susan, Su_Texas
 
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