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Medical Forum / Diseases and Disorders / Breast Cancer / May 2007About Zometa
My daughter has been on it for a yr now, I was reading your remarks about it before. She went to Dentist yesterday, and he said Zometa stays in your body for 10 yrs???? He said he has done work on people who were on it, and had no problems. If a tooth has to be extracted, it just has to be. >My daughter has been on it for a yr now, I was > reading your remarks about it before. She > went to Dentist yesterday, and he said > Zometa stays in your body for 10 yrs???? He > said he has done work on people who were > on it, and had no problems. I would love to know where that dentist got his information from about Zometa and how long it stays in the body. Maybe he should share it with Zometa's drug company, Novartis so they can research if it is the truth and share it with people like myself who want to know this. Maybe the dentist also has found additional information on precautions to take with Zometa patients which other dentists should be made aware of, in my opinion. I am very glad to hear he seems to have had success with doing work on Zometa patients. I would hope he would share his good success with other dentists so others can be protected from possible problems also. Thanks for sharing the good news! Bea 'NO FORWARDS OR SPAM, PLEASE" >> My daughter has been on it for a yr now, I was >> reading your remarks about it before. She [quoted text clipped - 18 lines] > > 'NO FORWARDS OR SPAM, PLEASE" The dentist is probably making an educated guess based on the available information. Given what is known it would be a reasonable way to proceed. Yes it is known that some of the drug stays in your body more or less forever, the unknown is whether it is the stored drug or the circulating drug that gives rise to the increased risk of disease. Do appreciate how rare this condition is: given the available statistics, any one dentist would have to operate on at least 300 long-term Zometa patients before having an evens chance of encountering a case of necrosis. And given the incidence of Zometa patients in the general population, that adds up to an awful lot of root-canal work and extractions. It's something most dentists are never going to encounter in their whole career. All surgery and dental surgery has a calculated risk attached, eg drug resistant infection, anaesthetic reaction, etc. This is just one more. Tim Jackson louella65@webtv.net wrote >>> My daughter has been on it for a yr now, I was >>> reading your remarks about it before. She >>> went to Dentist yesterday, and he said >>> Zometa stays in your body for 10 yrs???? He >>> said he has done work on people who were >>> on it, and had no problems. >> I would love to know where that dentist got his information from about >> Zometa and how long it stays in the body. Maybe he should share it [quoted text clipped - 24 lines] >All surgery and dental surgery has a calculated risk attached, eg drug >resistant infection, anaesthetic reaction, etc. This is just one more. Not only that, but speaking as someone who frequently suffers dental abscesses and needs remedial root canal work, I can't see that there's any alternative, unless removing teeth has no negative effects. I would have far fewer teeth than I now have if I'd had to have an extraction every time I needed dental work done, and I wouldn't be very happy about that. Fortunately for me, I don't have to make the decision, but I'm pretty sure I would take the risk and have the work done. Dental pain is the worst I've ever suffered.  Signature"It's easier to get forgiveness than permission." Rear Admiral "Amazing" Grace Hopper >All surgery and dental surgery has a > calculated risk attached, eg drug resistant > infection, anaesthetic reaction, etc. This is > just one more. >Tim Jackson "This is just one more"???? You are comparing Osteonecrosis of the Jaw to "normal" risks of dental surgery?? I can't believe what I read. It's ok, Tim. It's healthy for people to disagree once in a while. Bea 'NO FORWARDS OR SPAM, PLEASE" >> All surgery and dental surgery has a >> calculated risk attached, eg drug resistant [quoted text clipped - 10 lines] > > 'NO FORWARDS OR SPAM, PLEASE" What I mean is that the risk is in the same ball-park as things like the risk of a life-threatening infection such as MRSA or c.difficile after surgery. I am not belittling the risk or the unpleasantness of the condition, but to keep it in proportion it puts the hazards of invasive dental surgery on a par with say an appendectomy. I think the original story rather over-hyped the danger, and we all tend to forget that there are some small risks of major complications in just about any intervention. While this is certainly an increase in risk and an unpleasant disease, it does not constitute a massive increase in the overall risk of something nasty happening. I think the issue is compounded by the attitudes of (dentists') insurance companies. Inevitably when faced with a new hazard that they have not yet been able to assess the actuarial cost of, they are likely to take an attitude of "just say no". And anyway, as another poster wrote, there isn't really a lot of choice. Tim I am still going through the process of root canal when I first posted the problem of Zometa and have to accept that its there in my body. I am also praying that this root canal treatment is 'successful' and not going to get reinfected. I am new to dental problems as i have only suffered with minor cavities all of my 52 years! I probably wont have another infusion of this drug and will reassess my decision next year. I really am worried about having an extraction at this stage (I had Zometa in March). Looking at my xrays now there could be 2 other molars that may need 'root canal' in the future due to how deep the cavities were. Hopefully I will sail out of this problem unscathed for another 15 years!! Mary E. >>> All surgery and dental surgery has a >>> calculated risk attached, eg drug resistant [quoted text clipped - 31 lines] > > Tim > I am still going through the process of root canal when I first > posted the problem of Zometa and have to accept that its there in my [quoted text clipped - 7 lines] > the future due to how deep the cavities were. Hopefully I will sail > out of this problem unscathed for another 15 years!! Mary E. One important point is that if (as appears to be the case) the risk of ONJ is due to accumulation of bisphosphonates in the bone, then the risk is cumulative too. So if you haven't been on the drug for long, your risk right now should be minimal. But that does imply that if you are anticipating future dental surgery then you need to discuss this with your oncologist. Tim |
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