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Medical Forum / Diseases and Disorders / Breast Cancer / October 2003

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Kathleen Howard - 24 Oct 2003 14:14 GMT
hi everyone,
in the forum at www.breastcancer.org, there was a discussion about
taxanes,specifically Taxol and Taxotere.It stated 'they delay recurrence and
improve survival most clearly in women with positive lymph nodes and without
hormone receptors'.
Because I am ER- I was interested but confused.
Now, I may have read this piece out of context,but is it saying that these
taxanes can be taken as a precautionary measure by someone who had not had a
recurrence yet,or are they taken by those with more advanced cancers ?
I'm happy to 'eat my word' folks !!  I normally have to !
thanks
Kathleen
Kaye301 - 24 Oct 2003 14:39 GMT
Kathleen wrote << Now, I may have read this piece out of context,but is it
saying that these
taxanes can be taken as a precautionary measure by someone who had not had a
recurrence yet,or are they taken by those with more advanced cancers ?

Yes, many are given a taxane as standard adjuvent and now even neoadjuvent
treatment for early stage b.c. with positive nodes.
I had AC, 5 weeks of rads, then 2 Taxol and 2 Taxotere along with weekly
Herceptin for a year.  My intitial dx was stage IIb but because I had an
inflammatory component it was changed to stage III.
Tim Jackson - 24 Oct 2003 15:48 GMT
> hi everyone,
> in the forum at www.breastcancer.org, there was a discussion about
[quoted text clipped - 8 lines]
> thanks
> Kathleen

This statement is probably true of (adjuvant) chemotherapy in general: the
greatest benefit accrues to the patients at the highest risk of recurrence,
and to those for whom other treatments are not available, so node+ and ER-
has the most to gain

Taxanes were when first introduced restricted to stage IV patients, who have
less to lose when taking a treatment whose side effects and
contra-indications are not well known.  They are now becoming established
and accepted as suitable for use in earlier stages, and trials are
suggesting that they offer a benefit over previous chemotherapies.  From
what I have read the current gold standard for 'heavy' chemo, for women at
high risk, is I think a sequence of two different cocktails one of which
contains a taxane.

Tim Jackson
Kathleen Howard - 26 Oct 2003 18:49 GMT
thankyou folks for your help.!
Yes, as I remember,Taxol was  in the 'Trial', as an added extra on my ECMF
programme,but only if  you were one of the lucky ones to be chosen it have
it.......I wasn't.I do remember asking here at this site if I could have
'bought' the Taxol,knowing it could have given me that little bit extra
something.
Anyway,
again,thanks.
Kathleen

> > hi everyone,
> > in the forum at www.breastcancer.org, there was a discussion about
[quoted text clipped - 27 lines]
>
> Tim Jackson
 
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