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Medical Forum / Diseases and Disorders / Breast Cancer / October 2003

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mets to.....?

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DebITRC - 28 Oct 2003 00:15 GMT
I thought breast cancer mets typically went to bones.  Is it common for them to
first appear in the lung?

Deb
Tim Jackson - 28 Oct 2003 08:46 GMT
> I thought breast cancer mets typically went to bones.  Is it common for them to
> first appear in the lung?
>
> Deb

Yes.

Bone, lung and brain are the commonest mets, skin and other organs are also
possible sites.

Tim Jackson
Kaye301 - 28 Oct 2003 15:44 GMT
Tim wrote << Yes.

Bone, lung and brain are the commonest mets, skin and other organs are also
possible sites.

Tim Jackson

I was told that breast  cancer can metastasize anywhere if there is
lymphovascular invasion.  However, when talking about 'common' one for breast
mets to be found, it is generally assumed that one is referring  to both the
most common area(s) for mets to occur as well as this being for the most common
of the breast cancers--invasive ductal.
The second most common cancer, found in about 12 ro 15% tends to have a
different metastatic pattern.  It is more common for that to metastasize in the
abdominal areas and gastrointestinal tract, including colon, I believe.  The
3rd most common site for metastases for lobular is the retroperitoneum.

Interestingly, I recently learned that this is not common knowledge amongst
radiologists, I learned.  We had a discussion with an acquaintance/friend who
is a general radiologist who works in a private hospital setting.  He was
unaware that lobular metastasized differently and that the retroperitoneal area
was a common site for mets from lobular.

Thus, that makes us even further question the findings from the first CT scan
I had.  Although it was 'clear' for metastatic disease, it reported that there
were several enlarged retroperitoneal nodes (up to 1 cm in size)  not likely
associated with breast cancer.
That statement is true for the majority of breast cancers but not true for
lobular.  Retroperitoneal node involvement can be associated with colon/rectal
cancers.

Prior to my first surgery (bilateral mastectomy) which was done 23 days after a
somewhat invasive biopsy (core biopsy where 5 areas were taken) at a time when
my nipple had begun to show daily change and 9 mos. after mass was first shown
to dr.s, I first had rectal bleeding.  It surprised me.  Since it happened in
the dr's office, in a small restroom, I showed it to the surgeon.  She thought
it possibe hemmrhoids (sp?) or fissure.  I guess those are plausible
explanations but no further evaluation was done.  It coninued over the next
month or two--bright red blood.  It stopped though after I completed the first
4 rounds of the first chemo I had (4 AC).

Interestingly, I also learned that doctors are only held responsible for
knowing what most doctors are assumed to know.  I am guessing that perhaps he
is required to know only the 'most common' of expected events that occur in the
majority of cases.  I have no idea if the radiologist who interpreted my first
CT scan was aware of the different metastatic pattern for lobular.  I also
don't believe that he was even aware of the type(s) of b.c. that I had nor was
he requred to know.  In addition, he never had any direct contact with me--the
patient.  

I didn't know  most of the above until recently.  I am not sure I would have
wanted that information from the start, though.  It does lead me to think that
this may contribute to one of the reasons cancer patients tend to have a better
outcome, overall, if treated at a specialized cancer center.  Just some food
for thougt...

Again, I may be a bit of a rebel here but it is hard for me to accept the
rhetoric that early treatment of metastases does not increase overall survival.
There is lack of standardization in which metastases are diagnosed.  There may
be general guidelines, but they are not strict enough in terms of being
followed or in their interpretation to insure valid standardization.  In
addition, patients are monitored under differing schedules.

On another board one patient questioned whether or not she was receiving too
many scans.  After treatment of stage II bc with I believe 2 positive nodes,
she was receiving both bone and CT scans every 3 mos.  Most wrote back to her
that was excessive.  She finally asked her oncologist who told her this is the
protocol he uses for those with aggressive (high grade) cancers in which there
was positive node involvement for the first year after treatment.

I also found my oncologist more aggressive after the first year.  Now, if early
treatment of metastases does not improve long-term survival, why would this be
a practice used by some oncologists?

I also recently found a medical site which discusses the lack of consistency
used in terms of deciding when/what to use for treatment (of mets) I think.
So, if this lack of consistency is widespread with so many of these related
issues, there have been no valid studies to evaluate the efficacy of early
treatment of metastases.

Latest studies of initial adjuvent treatment, though, are showing that those
who have sequential, polychemotherapy seem to do better than those who have
only a single regimen.  And, although the following may have some confounding
ascertainment bias, but the only two women I know who are alive for more than
10 years who had many positive nodes (one had 14 and the other had over 20
positive nodes) and were somewhat younger at time of dx, had one thing in
common.  They were both given weekly chemotherapy for over a year.  The gal who
had 14 nodes was dx'd in her early 30's with a very aggressive form of b.c.
although she doesn't remember the type.  As far as her treatment, she was given
3 different drugs, and one of them was not or not yet a commonly used drug (had
some obscure number).  Her dr. told her she was going to be given a higher
dose, more frequently because of her young age.  This was 16 years ago, and she
had had no signs of recurrence as of this time.
Pat from Apple Valley, CA - 28 Oct 2003 19:08 GMT
This was very interesting, as I had Lobular also. I will certainly keep
an eye on my nether regions more closely..Pat frpm Apple Valley, CA

>Tim wrote << Yes.
>
[quoted text clipped - 91 lines]
>
>  
Kaye301 - 28 Oct 2003 22:28 GMT
Pat in  Apple Valley wrote<<
This was very interesting, as I had Lobular also. I will certainly keep
an eye on my nether regions more closely..Pat frpm Apple Valley, CA>>

The scarey part of al this is that it further reinforces the need for us to
take an advocational role which we shouldn't be fell forced into the necessity
of doing--at least not all the time and for something like cancer.   It is
emotionally and mentally exhausting.  It resulted in a fear that I if I leg go
and give some of this up it is going to come back to haunt me--and it has.
What I reported was only one small part of all this.  It keeps happening almost
every step of the way (and NO I am NOT paranoid).  I am amazed that it has
happened again and again--both with the non-profit HMO system and with private
dr.'s as well.
I won't bore you guys with a repeat of all the details but will add one that
comes to mind--and that was the protocol for radiation.   Now, again, at time
of my dx, I knew nothing about b.c. or treatment.   An acquaintance/friend who
also had b.c. told me I should ask for a boost when having radiation.  Now, I
had no idea what radiation involved, let alone what a boost was.  However, I
did inquire about the possible need for such.
The radiation oncologist told me that it wasn't needed.  He was basing my
treatment on the main tumor I had--a 2.5 cm invasive lobular carcinoma that was
stage II.  I asked him if he was sure I didn't need a boost.  He said I didn't.
During the course of radiation one is checked by a radiation oncologist
several times--usually by dr's different than the one who was the initial rad.
onc. you  met wit I needed it.  Hmm, interesting food for thought--got me
thinking--shouldn't I be given a choice?  I wasn't.  Anyway, after radiation
was completed and before I started Taxol I saw my regular oncologist (in
10/01).  I now knew a little more about b.c. than when I did at time I first
saw him in 4/01.   I asked him if I did or didn't have inflammatory b.c.  I had
read in a standard b.c. text that we checked out from the library that I was in
the gray area for that too.  He said he felt that what was going on was IBC
(and according to criteria for IBC it is/was, although a rarer presentation).
I then asked him if I had IBC wasn't the cancer more advanced than stage II?
He said it was and changed my staging on the reports to stage III.
Looking back, however, the radiation oncologist based his treatment protocol on
the fact that the initial tumor was stage II with clean margins.  Also, I don't
understand why the radiation oncologist did not take into account that I also
had the IBC (separate tumor in the nipple within dermal lymphatics) as well as
high grade DCIS with comedo necrosis in his decision about treatment protocol.
I have also since learned that the location of my tumor--upper inner
quadrant--made me at higher risk for internal mammary node involvement and risk
of local recurrence.  I do not believe that parameter was considered either.
I did have a chance to discuss this at a later time with a different radiation
oncologist who indicated that in my situation he would have given a radiation
boost, based on those parameters.
This whole thing is so mind-boggling, I am not sure which way to go sometimes.
Interestingly, there was a gal online on a different support group who took her
dog to a vet for a problem and wound up getting opinions from 4--each
different.  One recommended euthanasia.  Another recommended medication, using
steroids.  I am not sure which of the others recommended what--but she took the
combined recommendatins of two fo them and gave her dog supplements and
chiropractic adjustments (for neck disc problem).  Sje wemt on to say it took
her 6 months of diligent effort but it paid off and the dog was alive and well.
She learned to apply that 'lesson' to herself.  Different dr's have different
education and different ways of dealing with the same problem area.   There may
also be an art to treatment as well...Just some more food for thought...  
Kaye301 - 28 Oct 2003 23:54 GMT
Kaye wrote/or didn't quite write<< During the course of radiation one is
checked by a radiation oncologist
several times--usually by dr's different than the one who was the initial rad.
onc. you  met wit I needed it.  Hmm, interesting food for thought--got me
thinking--shouldn't I be given a choice?  I wasn't.  >>

AOL must have  hiccoughed.   shoud havr read after onc. you met with, I asked
this other rad. onc about boost and was told that I was in the 'gray area' for
a boost.
Pat from Apple Valley, CA - 29 Oct 2003 21:09 GMT
I was supposedly a IIB quarter size mass with 4 of 19 nodes positive,  
Lobular Carcinoma. I was given a boost of 6 or 7 treatments. a total of
36 radiation treatments. I had 4 A/C and 4 taxol's.... My Onc now won't
order the CA27/29 or what ever it is as he says it just makes you
worry...So no tumer markers...Mine were going up, so I guess I just have
to guess. Now every ache I get I wonder...I'm usually not prone to
aches....Pat

>Kaye wrote/or didn't quite write<< During the course of radiation one is
>checked by a radiation oncologist
[quoted text clipped - 7 lines]
>
>  
A. P. Thorsen - 28 Oct 2003 18:11 GMT
> Bone, lung and brain are the commonest mets, skin and other organs are also
> possible sites.

IIRC, the liver is also a fairly common site.

Ann T.
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