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Medical Forum / Diseases and Disorders / Breast Cancer / January 2006FEC-100 and Taxotere protocol
Hi all I'm not sure if you remember but I started chemotherapy for breast cancer in October. I was to have 6 cycles of FEC-100. Since then my oncologist has told me that there is a new clinical trial showing 3 cycles of FEC-100 and 3 cycles of taxotere to be slightly more effective. This protocol is not yet approved in Canada and with our public health system I cannot buy taxotere privately so I am going to Ireland for 2 taxotere treatments as I can get it there. Has anyone heard of this treatment. I have searched the company site and the fda sites on taxotere and cannot find anything combining FEC-100 and taxotere in this manner. Apparently it was a Swiss trial, does that mean it would not be referenced in the fda site? If someone could even suggest where to look I'd be grateful. My oncologist is now on maternity leave so I can't go to her. I have committed to the treatment but would like to find some more information if possible. Thanks Moz > Hi all > I'm not sure if you remember but I started chemotherapy for breast [quoted text clipped - 17 lines] > Thanks > Moz I don't know of that trial, what I remember is trials with AC and Taxotere, that showed in principle that "classic" chemo and a taxane combined sequentially (often known as TAC therapy) gave an advantage over classic chemo alone (such as AC, CAF, FEC combinations). This is now standard treatment in some countries. Here is (among other things) a report on such an AC/TAC trial in 2001 that showed a significant improvement in response, which it concludes should be reflected in future survival. www.medscape.com/viewarticle/412804 Tim Jackson > Here is (among other things) a report on such an AC/TAC trial in 2001 > that showed a significant improvement in response, which it concludes > should be reflected in future survival. > > www.medscape.com/viewarticle/412804 I think this may be the Phase 3 version of the Phase 2 TAC trial Deborah did in 2000. She did 8 cycles of TAC and got great response. The trial protocol wouldn't allow for more than 480mg/m2 of Adriamycin, though - so after 8 cycles they dropped the A and she continued on C + Taxotere for another four cycles, then got dropped from the trial for disease progression. But - at least in our case the TAC thing was extremely effective; considering she was Stage 4 at dx back in August 1999 I think she's doing a hell of a job ;-) > I'm not sure if you remember but I started chemotherapy for breast > cancer in October. I was to have 6 cycles of FEC-100. Since then my [quoted text clipped - 13 lines] > committed to the treatment but would like to find some more information > if possible. What's not approved in Canada? Alberta seems to have FEC100 with 4 cycles of Taxotere but I think it's for stage III http://www.albertabreast.com/patientmd/stage3.php (bottom of the page) I thought I saw one but Luxembourg http://www.clinicaltrials.gov/ Docetaxel or taxotere and breast that gives me 50 clinical trials - have to wade through each. The other way, I searched was with taxotere AND each name of FEC, AND breast Ontario http://www.cancercare.on.ca/pdf/pebc1-20s.pdf Dec 2004 seems to be the latest Practice Guidelines (PEBC) Maybe there are no Practice Guidelines nor clinical trials for someone your age. Would these people and/or a different oncologist help you sort it out? http://www.cancercare.on.ca/ J Hi Thanks for the responses. What isn't approved is using Taxotere in Stage II adjuvant treatment. I know it's used for Stage III and above and for other forms of cancer but using it in earlier stages hasn't yet been approved. It is good to see the combination of the FEC-100 and taxotere though, although mine is 3 sessions of each, it does ease my mind. When I looked at the treatment for Stage II, even high risk, which I am it has FEC-100 X 6 which is the same as in Ontario. Thanks Moz |
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