Benign breast lumps cancer link  

http://news.bbc.co.uk/1/hi/health/4699621.stm

Breast lesions can be picked up by scans

Women who have certain types of benign breast disease have a far
higher risk for breast cancer, say US researchers.

Identifying and closely monitoring these women could help save lives,
the Mayo Clinic team believe.

Although most non-cancerous breast lumps do not increase future risk
of breast cancer, they found faster growing and more abnormal types
did.

This finding, in the New England Journal of Medicine, held even if
there was no family history of breast cancer.

Benign breast lumps

The lifetime risk for breast cancer in women is one in nine, with over
38,000 new cases each year.

The first sign may be a lump in the breast.

However, often the lump is actually not cancerous, which doctors had
thought meant there was no increased future risk of a malignant
tumour.

 Our goal is to do a better job of risk prediction for women

Lead researcher Dr Lynn Hartmann

The only way to tell for sure whether or not a lump is cancerous is to
take a sample of cells, called a biopsy, and examine this in the lab.

In the Mayo Clinic study, the researchers looked at biopsy samples
from 9,087 women aged 18 to 85 with benign breast lumps that had been
taken at their clinic between 1967 and 1991.

They asked a pathologist who did not know the diagnoses of the women
to assign the lesions to one of three categories - proliferative
(faster growing), non-proliferative and atypical (abnormal).

The risks

The researchers then checked how many of the women went on to develop
breast cancer - 707 cancers were found over a period of 15 years.

With this information they were able to check at whether the category
of the benign lesion examined was linked to future cancer risk.

Women with proliferative or atypical benign tumour samples were more
likely to have developed breast cancer than those who had
non-proliferative benign breast lumps.

According to the study, six out of 100 women with a non-proliferative
benign breast lump would develop cancer within 15 years, compared to
10 out of 100 women with proliferative benign breast lumps and 19 out
of 100 women with atypical benign breast lumps.

For women of the same age, in general the risk of developing breast
cancer over 15 years is five per 100.

Advice

Lead researcher Dr Lynn Hartmann suggested women who have a breast
lump biopsy that is benign might want to discuss the possibility of
additional risks with their doctors.

"Our goal is to do a better job of risk prediction for women," she
said.

Emma Pennery, nurse consultant at Breast Cancer Care, said: "It is
important for women of all ages to be breast aware. This means knowing
how your breasts look and feel normally.

"If someone notices unusual changes in the breast, it is important
that they see their GP."

Professor Charles Coombes at Cancer Research UK said: "This is an
important study which demonstrates that patients who have had a breast
operation for benign breast disease showing abnormal cells should be
closely monitored and be on long-term follow-up.

"Patients who are uncertain of their diagnosis should ask their
doctors for confirmation. Patients with a strong family history of
breast cancer should continue to be followed up closely, but
especially if they have had a biopsy for benign breast disease."


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