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Medical Forum / Diseases and Disorders / Breast Cancer / May 2005

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Can Arimidex Cause UTIs??

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Bea - - 11 May 2005 14:49 GMT
Tim once posted that no subject is too sensitive for us to discuss here
so I hope I can ask my question without causing anyone embarrassment.
Does anyone know if taking Arimidex for ER+ bc can cause any type of
urinary or urinary tract infections?

I am taking it and have developed a "weird" problem which my gyn and
urologist do not seem to know what is causing it.  All they want to do
is fill me full of antibiotics (Bactrim DS) and Nitrofurantoin which is
not eliminating the problem but just giving me all sorts of "other"
problems including upsetting my stomach.  When I saw them I told them
about my bc and that I was on Arimidex but no one seemed to tie it with
the problem.  They did urine tests which showed I did not have a UTI
but gave me the drugs "as a preventative measure".  

I have had Cystitis in the past "many" years ago and this is not the
same symptoms.  This is why I think it is somehow connected to the
Arimidex.  However, I don't see urinary problems listed as a side effect
of Arimidex in my PDR.  

Since Estrogen is very important to a woman, can taking the Arimidex
which basically shuts it off (from what I think I understand) cause
problems in the urinary or bladder area?  I am Post-Menopausal.  This
has been going on for about 2 months now and if any one has any
information which can help me, it will be greatly appreciated, as usual.
Thanks so much!

Bea
A. P. Thorsen - 11 May 2005 17:24 GMT
> Tim once posted that no subject is too sensitive for us to discuss here
> so I hope I can ask my question without causing anyone embarrassment.
> Does anyone know if taking Arimidex for ER+ bc can cause any type of
> urinary or urinary tract infections?

I don't know . . . I'm on Arimidex, and haven't had any UTIs, despite
some history of getting them every once in a while.

What are the symptoms?  With UTIs in the past, I've had a burning
sensation (in general & when urinating) around the urethra and a feeling
of needing to urinate frequently even when my bladder was actually
empty.  Sometimes the urine would be darker than usual, and I think once
might have had a small trace of blood.

For what it's worth, I've also found that local irritation can have
similar symptoms to a UTI.  That kind of irritation could come from a
change in sexual activities; new underwear in a different fabric; bike
riding if it's not a regular activity; perhaps a sensitivity to a new
laundry detergent, powder, lotion, scented or otherwise different toilet
paper, or the like; or any one of a jillion similar things.

And yes, nothing is too sensitive to discuss (well, maybe the relative
"goodness" of medical systems in the UK & US is too sensitive <grin>,
but nothing about symptoms, diseases, side effects, coping, etc., is too
sensitive!).  Rest assured, this topic doesn't even come close to being
the most extreme that's been discussed in this group since I've been here!

I hope you're able to figure out what's going on . . . I've always found
UTI symptoms *very* annoying.

Ann T.
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Bea - - 11 May 2005 19:07 GMT
>What are the symptoms?

Thanks so much for the quick response Ann.  My symptoms are nothing like
what you described and what I know from experience with UTI.  I tried to
explain this to the doctors  but they seemed more interested in giving
me an RX and the gyn did not even bother to exam me.  It could not have
been caused by any of the examples you so kindly shared either for
personal reasons.

I did some reading while waiting for any responses and what I did find
out is that when a woman lacks Estrogen to lubricate the walls of this
area it can thin out and cause the symptoms you described and the
rawness I have developed.  I think the Arimidex shutting off my Estrogen
to protect me from a recurring bc (hopefully) has caused this problem
and guess what the remedy mentioned for it was?   Estrogen cream or
pills!!  Well I guess I am out of luck unless I can find a gyn who will
understand what is going on and find something else to help me.  

Thanks for making this so easy to discuss.  I am from a generation who
were not allowed to say the word "pregnant" so I sure have come a long
way since I found you fantastic people.  
(Not "all" Americans are as liberated as some think.<g)

Thanks again!

Bea
Tim Jackson - 11 May 2005 22:35 GMT
>>What are the symptoms?
>
[quoted text clipped - 22 lines]
>
> Bea

Could it be a fungal infection?

Tim
A. P. Thorsen - 12 May 2005 00:51 GMT
> I did some reading while waiting for any responses and what I did find
> out is that when a woman lacks Estrogen to lubricate the walls of this
> area it can thin out and cause the symptoms you described and the
> rawness I have developed.  

I wonder if it would help any to apply one of the "personal lubricant"
products that are used (usually for sexual reasons, I admit) to reduce
friction and restore moisture, such as Astroglide?  It's available over
the counter, and is not an estrogen-based thing.  It's basically sort of
a water-soluble lotion.  It can be bought online from mainstream-type
stores, if it seems worth trying but buying it at a local drugstore
seems embarassing.

Their web site (www.astroglide.com) also claims that vaginal dryness
(not exactly what you're reporting, I know) can be eased by drinking
plenty of water, and doing Kegel exercises to improve circulation in the
lower pelvic area.  If you're having some difficulty related to tissue
dryness caused by low estrogen, maybe (I hope?) there's some potential
for those things to help your symptoms even though in a slightly
different area?

I'm sorry, I'm speculating a bunch here -- probably not helpful.

Hope you figure out something!  Perhaps a new OB/Gyn doc, or being a
little more assertive with the one you've got so s/he at least does an exam?

Best wishes,

Ann T.
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Mary Fisher - 12 May 2005 16:23 GMT
> Tim once posted that no subject is too sensitive for us to discuss here
> so I hope I can ask my question without causing anyone embarrassment.
> Does anyone know if taking Arimidex for ER+ bc can cause any type of
> urinary or urinary tract infections?
>
> I am taking it

How long have you been taking Arimidex?

Mary
Bea - - 13 May 2005 03:32 GMT
>How long have you been taking Arimidex?

>Mary

Over a year ago my first Oncologist had me on Tamoxifen for a few months
but when I changed to my new Oncologist, he said since I was
post-menopausal I was supposed to be on Arimidex.  I have been on it for
about a year now and the problem I am having started about a month ago.
It is definitely not a yeast infection.  I think the recommendation
given in another post about a cream would be very helpful if I can get
hold of the cream.  I am due to see my gyn in June and I will see if she
knows of something I can get locally.  Thanks to all for the
recommendations and the advice.

Bea
Mary Fisher - 13 May 2005 10:53 GMT
> >How long have you been taking Arimidex?
>
[quoted text clipped - 4 lines]
> post-menopausal I was supposed to be on Arimidex.  I have been on it for
> about a year now and the problem I am having started about a month ago.

I just wondered why you think the cause might be the Arimidex, especially
since you've been taking it so long. I suppose we clutch at straws ...

I hope you find some relief, it must be very distressing.

Mary
Bea - - 13 May 2005 14:42 GMT
>I just wondered why you think the cause might
> be the Arimidex, especially since you've been
> taking it so long. I suppose we clutch at
> straws ...
>Mary

The reason I am suspicious of the Arimidex is because I always
understood that Estrogen was very important to women for their bones and
in this area.  Since the Arimidex shuts off my Estrogen and is causing
me all these other menopause symptoms (hot flashes etc.) I wondered if
the lack of it could be the reason for unusual dryness and problems in
the vaginal area.  Maybe it just takes a while being on it for some of
the symptoms to show up.  

I posted my question on this site because I wondered if other women on
Arimidex had noticed this type problem with it.  Evidently it must not
be the cause or is not common to all women.  I'm clutching at straws
because my gyn and urologist prefer to stuff me with antibiotics even
though my tests show I have no UTI.  If I don't get some better answers
from them in June, I will seek new doctors.

Bea
Passerby @midnight.com - 16 May 2005 02:25 GMT
> >I just wondered why you think the cause might
> > be the Arimidex, especially since you've been
[quoted text clipped - 18 lines]
>
> Bea

Hi Bea...

My sister has been on Arimidex for 2 years and experienced vaginal bleeding
and some pelvic discomfort sometime back...not sure exactly when.. She saw
her primary care physician, after mentioning it to her oncologist who
suggested she do so, and was treated with antibiotics for a UTI, though
tests came up negative for an infection.  She recently started experiencing
the same symptoms, was tested again and no signs of a UTI were evident.
She's going to talk to her oncologist about it again.

See Less Common Side Effects (both UTI and vaginal bleeding are listed)

http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ari1028.shtml

She is going to speak to her oncologist about this development, since it
doesn't appear to be a UTI.

Good luck getting to the bottom of the problem.  I heartily concur with
seeing new doctors if you get the same non-answers and treatment.
A. P. Thorsen - 16 May 2005 14:47 GMT
> I think the recommendation
> given in another post about a cream would be very helpful if I can get
> hold of the cream.

If you're talking about the astroglide or equivalent, and you're in the
U.S., you should be able to get it in any of the big chain drug stores
(CVS, Rite-Aid, Walgreen's . . . hmm, what is that one out West . . .
Osco?).  It'd likely be near either "feminine hygiene products" (i.e.,
 treatments for yeast infections, "intimate" deodorants, etc.) or near
condoms.  It's an over-the-counter thing.  Or you can get it or similar
products at (for example) www.drugstore.com  .

Ann T.
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