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Medical Forum / Diseases and Disorders / Breast Cancer / February 2005

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Coming off Dixarit & Efexor

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News - 22 Jan 2005 19:58 GMT
My wife was diagnosed with breast cancer 14 months ago, she had a lumpectomy
and then radiation. She was taking tamoxifen for about 12 months and more
recently she has been switched to Arimidex.  She has also been taking
venlafaxine(Efexor) and clonidine (Dixarit) to help suppress the terrible
hot flushes.   Also because she was getting hardly any sleep her GP
perscribed Zopiclone. She is very keen to stop taking the venlafaxine &
Clonidine, because of the side effects.   She has tried stopping both at
once and has suffered severe headaches, shiverings and dramatic temperature
swings and generally feeling unwell.   Her GP said just to stop taking them
and the withdrawal symptoms would  pass.

Has anyone else had experience of coming off these drugs, what advice can
you give.  At the moment my wife has gone back to taking minimal doses of
each, which seems to help a little.
Many thanks

Nick & Chrissie
eveline - 22 Jan 2005 21:36 GMT
> My wife was diagnosed with breast cancer 14 months ago, she had a lumpectomy
> and then radiation. She was taking tamoxifen for about 12 months and more
[quoted text clipped - 13 lines]
>
> Nick & Chrissie
Both drugs - especially the Clonidine have warnings about withdrawing them
abruptly.
If your doctor is not able to give you a safe withdrawal schedule, I suggest
you call the pharmacist and let him help you with a withdrawal schedule.
Most of these type drugs should not be stopped abruptly without a gradual
withdrawal.

My best wishes,
eveline
Whataday - 15 Feb 2005 21:05 GMT
Hi Nick

I am very curious on how your wife is doing.  At the age of 36, I was
diagnosed with Breast Cancer (19 months ago), had a lumpectomy, chemo and
radiation and then started taking tamoxifen in June, 2004.  I too am
suffering from the terrible hot flushes.  I just found out about Effexor
but my doctor thinks I should try Dixarit.  Currently I am not taking
either one and after reading this about your wife I am not sure I want to
take anything.  My doctors will not switch me to Arimidex because I was
not postmenopausal prior to chemo.  Aside from the hot flushes and not
sleeping did she have any other side affects?  Please let me know how she
is doing.  I will soon have to make a decision on if I want to take either
one of these drugs to get rid of the hot flushes.  I have contemplated even
stopping the tamoxifen. Thanks
Stephi - 16 Feb 2005 07:19 GMT
I was first DX'd 17 years ago in 1988, and had a lumpectomy followed by
radiotherapy and then was prescribed tamoxifen for several years - I was 34
at the time.

I loathed it because of the hot flushes and night sweats it gave me, and
stopped before the 5 years because I hated it so much. My doc described
tamoxifen as belt and braces, and I felt that if that made my life almost
intolerable, then I'd rather do without the braces and just rely on the
belt!!

Steph

> Hi Nick
>
[quoted text clipped - 11 lines]
> even
> stopping the tamoxifen. Thanks
 
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