> This group is only place I have seen this mentioned and have read some books
> on bc, and am wondering what the heck it is, what it does, etc. Enlighten a
> dummy please.
In brief, and in generalities rather than scientifically precise detail:
When breast tumors try to move out of the breast and invade other parts
of the body, often the first outside-the-breast spot where they
migrate is into lymph nodes in the underarm area.
The theory is that a tumor in a particular spot is most likely to first
invade a specific lymph node (or couple of 'em) that are most closely
connected to the area where the tumor started.
But, it's hard to tell exactly which lymph node(s) that would be, as we
all have slightly different lymphatic systems.
So, the doctors inject a dye at the location of the tumor. The dye
seeps through the lymphatic system. The first lymph node(s) where the
dye appears are the node(s) most likely to contain cancer cells.
They're called the "sentinel node(s)" be cause they sort of stand guard
between the tumor and the rest of the lymphatic system (and body).
The doctors then remove the sentinel nodes and examine them under a
microscope. If there are no cancer cells in them, it is unlikely that
the cancer has migrated into the lymph nodes at all. So, they don't
remove any more lymph nodes.
If there -are- cancer cells in the sentinel node, then many doctors go
ahead & remove other lymph nodes in the area to check things further.
The older alternative to the sentinel node procedure is for the docs to
simply go straight to removing many of the lymph nodes in the underarm
area to check them all microscopically, instead of looking at just the
sentinel node.
Does that make sense? (I'm sure that if someone else thinks this is an
inaccurate explanation, they'll correct me . . . . )
Ann T.
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Tim Jackson - 18 Dec 2004 09:53 GMT
>> This group is only place I have seen this mentioned and have read some
>> books
[quoted text clipped - 40 lines]
> Ann T.
> Remove 'dontsendspam' from address to reply by email
I might just add that this is a relatively new procedure and not adopted
everywhere, for two reasons.
Firstly the doctors need training in order to do the procedure
successfully, it's quite easy to mess up, which means falling back to
removing the nodes anyway.
Secondly because there is a significant percentage of false negatives,
where the found sentinel node does not contain cancer, but others do.
This seems to improve as training of doctors improves, and there is some
dispute over how significant it is in terms of outcome.
No one seems to be quite clear how much benefit is obtained by removing
these lymph nodes which contain (presumably microscopic) traces of
cancer, and so it is difficult to assess the risk of a few extra
terminal cancer cases against a lot of non-lethal but uncomfortable and
long term lymphedema cases.
Tim Jackson
Eva - 18 Dec 2004 22:33 GMT
> I might just add that this is a relatively new procedure and not adopted
> everywhere, for two reasons.
[quoted text clipped - 13 lines]
> terminal cancer cases against a lot of non-lethal but uncomfortable and
> long term lymphedema cases.
-------------
Welllllll.....I just had to deal with this issue. Just came home from the
hospital. Had modified radical mastectomy day before yesterday. Had asked
my doctor about doing the sentinel node biopsy procedure. She stated she is
well experienced with the procedure but didn't think it was a good idea in
my case since she knew from the beginning that I had some lymph node
involvement (prior to chemo).
Yes, I was disappointed. I dread lymphedema....but nowhere near as much as
I dread death. So, I consented to axillary node dissection, and we shall
see what happens.
Eva
Well here's my 2 cents on sentinel node. When the dye drains to a node the
very first one that it drains to is called the sentinel node. Or the first
node. And that's the one they remove to check for cancer. And if there is
no cancer in the "first node" then they believe that it has not spread.

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Kathy
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In God We Trust
> This group is only place I have seen this mentioned and have read some
> books
> on bc, and am wondering what the heck it is, what it does, etc. Enlighten
> a
> dummy please.