> My wife has just completed her post surgery A/C chemotherapy with the
> usual side effects and one episode of Absence Seizure after the fourth
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> probability of a patient being able to use their hands, walk, sleep
> and do gentle Taoist Tai Chi several months after the Taxol treatment.
I don't know if that particular statistic is available. It might be worth
reading the Taxol prescribing sheet, if you are comfortable with statistical
analysis. (http://bmsoncology.com/data/taxolx.pdf).
The main long-term reaction to Taxol is peripheral neuropathy, which seems
to be what you are concerned about. The term of reaction is not recorded,
but "severe" reaction occurs in around 1% of patients. I would think the
level of permanent symptoms you fear is rather rarer than that, the great
majority of (even severe) symptoms do disappear within a few months.
Hope this helps
Tim Jackson
A. P. Thorsen - 05 Aug 2004 14:48 GMT
>>What is the success rate with Taxol in respect to non-lasting side
>>effects? What I am looking for here is a rough estimate on the
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> level of permanent symptoms you fear is rather rarer than that, the great
> majority of (even severe) symptoms do disappear within a few months.
For most of us, the peripheral neuropathy is trivial, if present at all.
I'm about 3 years post-Taxol. When I get tired, my hands & feet start
to feel ever so slightly numb. If I walk or stand a lot (relative to my
usual activity level), the soles of my feet feel slightly numb. None of
this is sufficient to prevent any activity, or even render it difficult.
For me, the issue is not predominantly pain (though it does "feel
funny"), but mainly sense-perception through the affected area. If it
were necessary to read Braille, that might possibly be a problem at
times (I dunno, though -- I can't read Braille!)
The most severe case of neuropathy from taxanes I know of is a friend
who's about 6 years out from Taxotere (not Taxol). She can *do*
everything she ever did, to the best of my knowledge. But she's more
inclined to (say) drop things, get minor cuts or burns, etc., because of
the decreased sensitivity. Tasks that require fine sensory feedback
from the fingers (e.g., certain hand-crafts) are more difficult, and
require more focused attention.
I've talked to at least 10, and maybe as many as 20, people who've had
taxanes; this is the basis for my perceptions.
Based on that, it would seem very unlikely that your wife would have any
difficulty doing the things you describe. I was able to do a Tai Chi
spear form, without either dropping my spear, or skewering anyone <g>!
Ann T.
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>My wife has just completed her post surgery A/C chemotherapy with the
>usual side effects and one episode of Absence Seizure after the fourth
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>John_M_H
>
I had taxol at the end of 2000. I have been clog dancing since Jan. of
2003. I believe I could have sooner if I had found a class. The worst
thing about it is that when I sit for long periods of time I have
trouble getting straight when I stand. After getting upright I am fine.
The same in the AM when heading for the toilet, My legs are a little
stiff, after a few steps all stiffness is gone. I did drop a few things
at first, a pork roast for example, but am not sure it was the taxol
effects. Good luck to your wife. I think it is pretty doable...Pat from
Apple Valley, CA
According to my oncologist and verified from personal experience, the major
side effect is being tired. The effect is cumulative with successive
treatments.
I did not experience any peripheral neuropathy. I did gain weight but that was
because of the steriods given in conjunction with the treatment.
For about a year, when I would get up in the morning, I felt about a hundred
years old joint wise. The doctor thought that could be a side effect of the
Taxol. It might also have somethibg to do with Tamoxifen.
Women in a breast cancer support group might have additional ideas.
Sassy