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Medical Forum / Diseases and Disorders / Asthma / February 2004

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advair and heart attacks??

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Ensoul100 - 04 Jan 2004 06:47 GMT
just had a friend tell me abt that, nurse in respiratory therapy told her

anybody heard of that??

ensoul

I refuse to answer that question on the grounds that I don't know the answer.
~ Douglas Adams

When will our consciences grow so tender that we will act to prevent
human misery rather than avenge it?
~Eleanor Roosevelt
CBI - 04 Jan 2004 23:21 GMT
> just had a friend tell me abt that, nurse in respiratory therapy told her
>
> anybody heard of that??

I don't think she has any idea what she is talking about.

--
CBI, MD
Dave - 26 Jan 2004 16:35 GMT
Actually, she is some what correct.
If you read the warnings it states that "Advair can cause a change in
the heart rhythm".  This warning was also at the end of the
commericals that ran over about a year ago.  The one with the American
Indian lady at the ruins in the S.W.   There was a blurb stating the
exact same thing.
My father went through this episode and died after being on Advair for
4 months.  His cardiac enzymes were negative meaning he did not have a
heart attack, however he was in V-Fib when the paramedics connected
him to the defib.

I contacted Glaxo Smith Kline, and they blew me off, however,,, they
did remove the warning from the commerical.  Pull up thier web site,
and look at the warnings under "Cardiovascular"

dave

> > just had a friend tell me abt that, nurse in respiratory
>  therapy told her
> >
> > anybody heard of that??
>
> I don't think she has any idea what she is talking about.
CBI - 27 Jan 2004 02:18 GMT
> Actually, she is some what correct.

"Abnormal heart rhythm" and heart attack are not the same
thing.

I don't think there is any evidence that it is worse than
the albuterol that it is designed to reduce and the risk of
both is vanishingly small. FWIW low oxygen levels and lung
diaeases in general can also cause abnormal heart rhythms as
can coffee and alcohol.

Signature

CBI, MD

Sarr Blumson - 27 Jan 2004 15:30 GMT
>"Abnormal heart rhythm" and heart attack are not the same
>thing.
[quoted text clipped - 4 lines]
>diaeases in general can also cause abnormal heart rhythms as
>can coffee and alcohol.

I think there's an opportunity for some education, here. The Serevent
half of Advair is a beta agonist which, in my naive understanding, that
it has essentially the opposite affect of the beta "blockers" (eg Inderal)
that are used to control chronic arrhythmia and fibrillation. So I would
expect that a beta agonies would increase the risk of these. Is this not
so?

Understanding that whether the increased risk _matters_ will depend on a
particular individual's situation. Despite what I've said, I've been
using Advair for a couple of years and Serevent for several years before
that and have found the benefits to be significant. But I do wonder what
will happen as I age (57 now).
Signature

--------
Sarr Blumson                    sarr.blumson@alum.dartmouth.org
http://www-personal.umich.edu/~sarr/

CBI - 29 Jan 2004 03:25 GMT
> I think there's an opportunity for some education, here. The Serevent
> half of Advair is a beta agonist which, in my naive understanding,
> that it has essentially the opposite affect of the beta
"blockers"
> (eg Inderal) that are used to control chronic arrhythmia
and
> fibrillation. So I would expect that a beta agonies would
increase
> the risk of these. Is this not so?

Sort of - there are a  few considerations:

First of all, Serevent and albuterol are beta-2 agonists
(i.e.they stimulate that receptor) that are relatively
selective for the receptors in the lung* whereas nearly all
commonly used "beta blockers" (AKA antagonists) are
"cardioselective" meaning that they are selective for the
beta-1 receptors found in the heart. Each one will affect
the other receptor to some degree but not as much as the one
for which it is specific. For this reason there is now
considerable evidence that a beta blocker can be carefully
given to some patients with asthma (and most patients with
COPD) that have a compelling reason to take the drugs (like
heart disease).

Secondly, you must consider the dose and route of
administration. Anyone who has worked in a  hospital,
espeically an ICU, has seen the heart race as the albuterol,
given by neb in high doses, stimualtes the heart. However,
you must remember that a 2.5 mg albuterol neb is the
equivalent of about 10 puffs of albuterol from an MDI and
most asthmatics don't take that much every 1/4 to 4 hours.
Giving the drug by inhalation maximizes the amount getting
to the lung receptors while minimizing the amount getting
intot he blood and reachig the heart.

The point is that while it is certainly possible for the
albuterol to stimulate the heart the dose, route, and
pharmacology all act to make the amount of stimulation
generally low. I know that it is not rare for people to feel
shaky or jittery with using albuterol but I am not at all
sure that this is by the same mechanism as we have been
discussing.

> Understanding that whether the increased risk _matters_ will depend
> on a particular individual's situation. Despite what I've
said, I've
> been using Advair for a couple of years and Serevent for
several
> years before that and have found the benefits to be
significant. But
> I do wonder what will happen as I age (57 now).

The other thing to consider is that you do not have the
option of just taking it and being relieved of risk. If your
doctor has prescribed it then presumably your asthma is not
otherwise well controlled. I have posted my opinion many
times that I prefer other measures to control the asthma
before reaching for the Serevent but the drug does have a
place (and despite these statements I do use it quite a
bit - mostly in smokers). As I stated in the other post, low
oxygen levels and uncontrolled lungdisease also can cause
abnormal heart rhythms so if your asthma is not well
controled it may be a matter of choosing which risk you are
going to take - but not having the option of not being at
risk.

Signature

CBI, MD

* The beta receptors in the heart are beta-1. The lung has
beta-2. There is a beta-3 that si mainly int he kidney and
is much less well understood and sems to have a role in
regulating blood pressure (some of the beta blockers blood
pressure lowering effects may actually be due to renal
beta-3 blockade).

wenda hunt - 03 Feb 2004 18:19 GMT
I'm curious dave did you pursue the drug company even more?
wenda
Dave - 05 Feb 2004 17:00 GMT
> I'm curious dave did you pursue the drug company even more?
> wenda

Oh, I tried.  I sent numerous emails to Glaxo, and only one lady would
talk to me.  She was kind and even seemed concerned, and tried to get
me in touch with the legal department.  They would have nothing to do
with me.  They refused to return my phone calls, and email.  I left
messages on voice mail, so they knew what I wanted.  I spoke with the
FDA, and they were aware of deaths from Advair,,, however there
weren't a lot.  Hey, one is too many if it is YOUR father.
He agreed that there were issues with Advair, and really appreciated
me taking the time to file a complaint.  He explained that there needs
to be some more deaths before they can take action.
All I wanted to do was speak to the people at Glaxo, but they wouldn't
give me the time of day.
I spoke with 2 local attorneys and they admitted that they didn't have
the grapes to take on the big boys.  So, I filed for a class action
suit.  That is where we stand right now.  I'll know more down the
road.
Colin Campbell - 05 Feb 2004 17:38 GMT
>I spoke with 2 local attorneys and they admitted that they didn't have
>the grapes to take on the big boys.  So, I filed for a class action
>suit.  That is where we stand right now.  I'll know more down the
>road.

Has it occurred to you that if you win - the most likely result is
that this medication will be removed from the market?

How many lives may be lost if this happens?

--
"It's not American foreign policy, or the plight of the
Palestinians, or America's longstanding support for Israel.
A group of people with money and weaponry have simply
decided that we, as a civilization, are unfit to live, and
want, eventally, to exterminate us."
'Christian Century' magazine
Circe - 05 Feb 2004 17:43 GMT
>> I spoke with 2 local attorneys and they admitted that they didn't
>> have the grapes to take on the big boys.  So, I filed for a class
[quoted text clipped - 5 lines]
>
> How many lives may be lost if this happens?

Maybe mine, for starters. My heart stopped due to a severe asthma attack
*before* I started taking Advair. Since going on Advair 7 months ago, I have
needed my albuterol only perhaps a half a dozen times compared to about a
half a dozen times per *week* before. Frankly, I think Advair is a wonder
drug that may very well be saving my life.

I'm sorry for Dave's loss, but my family (including three very young
children) almost lost me without Advair. What will he tell them if the
medication is pulled from the market and I experience another sudden onset,
severe asthma attack and this time, I don't get to the hospital in time?
Signature

Be well, Barbara
(Julian [6], Aurora [4], and Vernon's [23 mos.] mom)

This week's special at the English Language Butcher Shop:
Financing for "5" years -- car dealership sign

Mommy: I call you "baby" because I love you.
Julian (age 4): Oh! All right, Mommy baby.

All opinions expressed in this post are well-reasoned and insightful.
Needless to say, they are not those of my Internet Service Provider, its
other subscribers or lackeys. Anyone who says otherwise is itchin' for a
fight. -- with apologies to Michael Feldman

Dave - 06 Feb 2004 01:09 GMT
> >> I spoke with 2 local attorneys and they admitted that they didn't
> >> have the grapes to take on the big boys.  So, I filed for a class
[quoted text clipped - 16 lines]
> medication is pulled from the market and I experience another sudden onset,
> severe asthma attack and this time, I don't get to the hospital in time?

You need to open your eyes and find another medication if you are so
worried.  There are others out there that are safer.
I'm a medic, and I can't count the number of calls that I've run where
a pt is in full arrest and there is an Advair inhaler sitting on the
table or night stand.  In EVERY event that the pt was on Advair, NONE
had an asthma attack prior to arrest.
How can I in good conscience sit back and not do anything.  People are
dying and there is a good chance that it is because of this
medication.   In 15 years of being a medic, I've only run 1 call where
the person had a fatal asthma attack.  I'm not saying that it doesn't
happen more often, I'm only saying that I've only been on 1, and I've
been on dozens of cardiac arrest where there was an Advair packet in
plain sight.  It could just be a concindence, and I'm sure that the
good Dr that has been poo pah-ing me will say so.  The FDA agrees that
it is dangerous.  There are even warnings from the FDA that Advair can
cause "sudden fatal asthma attacks".  It is the serevent in the
product that is a killer.
Look around before you continue to bag on me.  I have serious
concerns, and so does Glaxo, or they wouldn't be putting the warnings
out there.

And speaking of nonsense, who is the idiot that said the inserts in
the package aren't meant for the pts. information.   How bizare that
anyone with MD behind his name would make a statement like that.  Do
you wonder why they call your business "a Practice"?
CBI - 06 Feb 2004 04:30 GMT
> And speaking of nonsense, who is the idiot .....

So, Colin is a colon, circe needs to open her eyes, other
are sepaking nonsense, and I am an idiot. To support this
you list rather implausible anecdotes about how many cases
of dead people with Advair nearby you have seen and contrast
that with the relative banality of the asthma cases (not to
mention the obvious difficulty of how you took a history in
every one of these people in full arrest to determine if
they had recently had an attack).

Then you wonder why you are not making friends and
influencing people. It would work a heck of a lot better if
you would drop the personal insults and present some facts.
For the record - "Prescribing information" is logically
enough usually intended for the prescriber. When an
information sheet is composed for the patient they generally
call it something else.

Signature

CBI, MD

Bob - 06 Feb 2004 15:47 GMT
On Fri, 06 Feb 2004 04:30:27 GMT, "CBI" <00_doc@mindspring.com> wrote

>For the record - "Prescribing information" is logically
>enough usually intended for the prescriber. When an
>information sheet is composed for the patient they generally
>call it something else.

Yeah.  An ad.

Pharmacies are good about giving you a "patient advisor" printout with
a new prescription.  Not that they would necessarily give you any more
information than your doctor would, but since you will be putting the
drug in your body, it makes sense to definitely ask the pharmacist
yourself about any dangerous side effects, and ask their opinion, just
in case there is any confusion or unanswered questions you may have.  
CBI - 07 Feb 2004 14:05 GMT
> On Fri, 06 Feb 2004 04:30:27 GMT, "CBI" <00_doc@mindspring.com> wrote
>
>> For the record - "Prescribing information" is logically
>> enough usually intended for the prescriber. When an
>> information sheet is composed for the patient they
generally
>> call it something else.
>
[quoted text clipped - 6 lines]
> yourself about any dangerous side effects, and ask their opinion, just
> in case there is any confusion or unanswered questions you may have.

I'm all for giving the patients information. It can be
helpful for them to have something in writing about what
types of things to look out for since it is ahrd to cover it
all in the office, hard to keep all the possible side
effects in mind for all drugs, and hard for patients to
remember what you said. The one beef I do have with the
pharmacy print-outs that I have sen is that they tend to
just list all the reported side effects with no distinction
made between how firmly established they are or how likely..

However, there print outs are nott he same as the package
inserts and they are composed by the pharmacy (or someone
they contract to do it) , not the drug companies or doctors.

Signature

CBI, MD

Circe - 06 Feb 2004 20:45 GMT
>> Maybe mine, for starters. My heart stopped due to a severe asthma
>> attack *before* I started taking Advair. Since going on Advair 7
[quoted text clipped - 11 lines]
> You need to open your eyes and find another medication if you are so
> worried.  There are others out there that are safer.

And none of them ever successfully controlled my asthma to the extent that
the Advair has done. One of the reasons I got a bit lazy about taking
inhaled steroids before was that they didn't seem to make a quantifiable
difference in my symptoms. Advair does.

In any event

> I'm a medic, and I can't count the number of calls that I've run
> where a pt is in full arrest and there is an Advair inhaler sitting
> on the table or night stand.  In EVERY event that the pt was
> on Advair, NONE had an asthma attack prior to arrest.

My father had asthma and died of a heart attack *due, most likely, to his
symptomatic mitral valve prolapse which caused fibrillation) before Advair
was even on the market. Are you somehow trying to suggest that people who
are on Advair can't have heart disease that might lead to heart attacks
*independent* of their asthma?

This is sort of like saying that insulin causes heart attacks because you
found patients in full cardiac arrest who were insulin-dependent diabetics.

> How can I in good conscience sit back and not do anything.  People
> are dying and there is a good chance that it is because of this
> medication.   In 15 years of being a medic, I've only run 1 call
> where the person had a fatal asthma attack.  I'm not saying that it
> doesn't happen more often, I'm only saying that I've only been on 1,

Well, of course, *my* asthma attack wasn't fatal, but it was awfully damn
close. Had it taken another 5 minutes to get me to the hospital, I almost
certainly would have died or suffered serious brain damage.

That said, after my event, I heard a *lot* of stories about people who died
of asthma attacks similar to mine. Usually, they died because they were too
far from a hospital when the attack started. All the more reason for such
folks to use the best medication to keep their asthma in check, and for some
of us, that best medication seems to be Advair.

> and I've
> been on dozens of cardiac arrest where there was an Advair packet in
> plain sight.  It could just be a concindence, and I'm sure that the
> good Dr that has been poo pah-ing me will say so.  The FDA agrees
> that it is dangerous.  There are even warnings from the FDA that Advair
> can cause "sudden fatal asthma attacks".

A "sudden, fatal asthma attack" isn't a heart attack. You just claimed above
that *none* of the patients you'd found in full cardiac arrest had had an
asthma attack prior to the event, now you're saying that Advair is causing
asthma attacks which are leading to cardiac arrests. Well, which is it?

> It is the serevent in the product that is a killer.

I am well aware of the concerns about serevent. I believe, however, that it
is serevent not used in conjunction with an inhaled steroid that has been
linked to sudden asthmatic death. Because Advair contains serevent as a
constituent element, the FDA must issue warnings about it, but it is my
understanding that serevent used in conjunction with steroids when asthma is
well-controlled (and this, IMO, is the key element--if Advair isn't
controlling asthma symptoms very well, I do agree that serevent could
present problems in the event of a serious attack). In my case, my asthma is
extremely well controlled with Advair, such that my husband says for the
first time in the 15+ years he's known me, I breathe like a normal person.

Again, I *am* truly sorry that you lost your father and I understand why you
are concerned. Still, given my history, I wonder whom you'd recommend my
family sue in the event that Advair is pulled from the market, no other
medication controls my symptoms well, and I die from another SAD episode?
Signature

Be well, Barbara
(Julian [6], Aurora [4], and Vernon's [23 mos.] mom)

This week's special at the English Language Butcher Shop:
Financing for "5" years -- car dealership sign

Mommy: I call you "baby" because I love you.
Julian (age 4): Oh! All right, Mommy baby.

All opinions expressed in this post are well-reasoned and insightful.
Needless to say, they are not those of my Internet Service Provider, its
other subscribers or lackeys. Anyone who says otherwise is itchin' for a
fight. -- with apologies to Michael Feldman

Dave - 07 Feb 2004 04:11 GMT
"Circe" <guavaln@yahoo.com> wrote in message news:<e0TUb.16401$> And none of >

> > and I've
> > been on dozens of cardiac arrest where there was an Advair packet in
[quoted text clipped - 9 lines]
>
>OK, now you are just being stupid.  Read it again... I said that
Advair CAN CAUSE (as in it can ALSO cause "sudden fatal asthma
attacks")
So, I'll spell it out because you can't read.   The Advair warnings
state that "Advair can cause a change in the heart rhythm" AND the
warnings ALSO state that "Advair can cause SUDDEN FATAL ASTHMA
ATTACKS"
I don't make this stuff up, Glaxo puts these warnings out, because the
FDA makes them.  If you don't read them, they don't care.

Would you like me to cut and paste the entire paragraph?????
At one point, you sounded like a decent, understanding person, with a
good head on her shoulders, now it is more like I'm trying to take
away something that you refuse to realize has serious side effects.
Hey, it's your decision.  All I was trying to do is shed a little
light on the subject.  If you don't want to hear the other side, that
is fine.  Truthfully I'm getting sick of the stupid a.s comments.
Obviously you can't read and comprehend what I've said, so I won't
bother you anymore.
I hope that you don't see the down side of this medication.  Obviously
you don't even want to know that it exist.
Colin Campbell - 07 Feb 2004 05:05 GMT
>>OK, now you are just being stupid.  Read it again... I said that
>Advair CAN CAUSE (as in it can ALSO cause "sudden fatal asthma
>attacks")

And you can be struck by lightning sitting at your computer.  

The question is: is the risk enough to warrant a discontinuation of
the medication?

You are saying that it _can_ happen.  How about telling us how
_likely_ this event is?

--
"It's not American foreign policy, or the plight of the
Palestinians, or America's longstanding support for Israel.
A group of people with money and weaponry have simply
decided that we, as a civilization, are unfit to live, and
want, eventally, to exterminate us."
'Christian Century' magazine
CBI - 07 Feb 2004 14:27 GMT
>> OK, now you are just being stupid.  Read it again... I
said that
> Advair CAN CAUSE (as in it can ALSO cause "sudden fatal asthma
> attacks")
> So, I'll spell it out because you can't read.

Dave, again I simply don't understand why you think that
these types of insults don't unfavorably predispose people
to the rest of your arguments. it really makes me wonder if
yuo are trying to make a point (in which case you are doing
yourself a disservice) or just trolling.

> The Advair warnings
> state that "Advair can cause a change in the heart rhythm" AND the
> warnings ALSO state that "Advair can cause SUDDEN FATAL ASTHMA
> ATTACKS"
> I don't make this stuff up, Glaxo puts these warnings out, because the
> FDA makes them.  If you don't read them, they don't care.

That is not what it says. It says that there has been an
association with using Advair and asthma deaths and then it
goes on to specifically reference the SMART study which has
been discussed at length on this group. It is the study that
found that kids who took Serevent without a steroid had
problems. This presumably would not apply to Advair or
anyone else taking inhaled steroids. It also says that there
have been increased deaths in people who starte dthe drug in
the context of acutely worsening asthma. Thsi is not
purprising since the drug is not intended to be used in this
way.

As for the arrythmias - they are generally supraventricular
arrythmias which are usualy not fatal. In fact, they are the
exact same type of arrythmia generally caused by lung
diseases like asthma so it would be ahrd to tease out what
is happening. Albuterol and Serevent generally do not cause
the ventricular arrythmias that cause sudden deatha nd are
more commonly triggered by coronary artery disease or low
oxygen levels.

> Would you like me to cut and paste the entire paragraph?????

Yes, I think that would be helpful - and the link tot he
page from where it came.

Signature

CBI, MD

CBI - 07 Feb 2004 14:12 GMT
> My father had asthma and died of a heart attack *due, most likely, to
> his symptomatic mitral valve prolapse which caused
fibrillation)
> before Advair was even on the market. Are you somehow
trying to
> suggest that people who are on Advair can't have heart
disease that
> might lead to heart attacks *independent* of their asthma?

I'd go even further than that - low oxygen levels and lung
disease itself both increase the risk of arryhtmias. The
fact of the matter is that more people die of coronary
artery disease induced cardiac arrythmias with no priorly
known heart disease every year in the US than are currently
taking Advair.

> This is sort of like saying that insulin causes heart attacks because
> you found patients in full cardiac arrest who were
insulin-dependent
> diabetics.

Exactly.

> I am well aware of the concerns about serevent. I believe, however,
> that it is serevent not used in conjunction with an
inhaled steroid
> that has been linked to sudden asthmatic death.

Exactly - that is THE link that has been made so far. It is
possible that there will someday be a link between Serevent
and some other types of fatal arrythmias but it hasn't been
found yet. Even if it does exist it will always be a
miniscule player in comparison to heart disease.

Signature

CBI, MD

ARoberts - 06 Feb 2004 00:32 GMT
> > I'm curious dave did you pursue the drug company even more?
> > wenda
[quoted text clipped - 3 lines]
> suit.  That is where we stand right now.  I'll know more down the
> road.

I'm sure that you believe that you are pursuing the right course, but I
don't believe that the merits are with you.  If the attorneys that you spoke
with thought that they had a chance of prevailing, they would grow an arbor
full of grapes instantly.

Advair, like any drug, has risks.  For me, the risk/benefit mitigates in
favor of having it available.
Dave - 28 Jan 2004 15:53 GMT
> > just had a friend tell me abt that, nurse in respiratory
>  therapy told her
> >
> > anybody heard of that??
>
> I don't think she has any idea what she is talking about.

You are entitled to your opinion, however by making a statement like
"I don't think she has any idea what she is talking about"  shows your
ignorance.  Do some research man, before you spout off.   Read the
warnings that Glaxo puts out, then stand there and say that they don't
know what they are talking about.

99% of the people out there will hear about someone dying because of a
cardiac arrythmia and turn around and call it "heart attack".
Maybe YOU don't know what you are talking about.
Serevent can kill.  The FDA makes that statement as well.  Be careful.
Colin Campbell - 28 Jan 2004 17:28 GMT
>> > just had a friend tell me abt that, nurse in respiratory
>>  therapy told her
[quoted text clipped - 8 lines]
>warnings that Glaxo puts out, then stand there and say that they don't
>know what they are talking about.

There are risks to everything we do in life.  We can all choke to
death on our next bite of food.

What we have to decide is whether the risks of using this medication
are greater than the risks of not using it.

BTW, I have had several military doctors tell me that asthma symptoms
can trigger a heart attack.

--
"It's not American foreign policy, or the plight of the
Palestinians, or America's longstanding support for Israel.
A group of people with money and weaponry have simply
decided that we, as a civilization, are unfit to live, and
want, eventally, to exterminate us."
'Christian Century' magazine
Dave - 01 Feb 2004 15:31 GMT
> There are risks to everything we do in life.  We can all choke to
> death on our next bite of food.
>
> What we have to decide is whether the risks of using this medication
> are greater than the risks of not using it.

The bigger issue is not whether we will die taking a bite  of food, or
stepping off a curb into traffic etc. but whether the drug companies
are doing a fair job of informing us that the medication that we take
will end up killing us.  Granted a lot have serious side effects, but
when they bury a warning deep inside their documents and disguise the
warning with language that the layman wouldn't understand, that is
criminal.
The warnings that come in the Advair package doesn't serve the public.
And who is to say that the benefit out weighs the risk.  NOT ME!  Not
when you lose a loved one.  I hope that no one else has to go through
what we have.
Colin Campbell - 01 Feb 2004 17:27 GMT
>> There are risks to everything we do in life.  We can all choke to
>> death on our next bite of food.
[quoted text clipped - 9 lines]
>warning with language that the layman wouldn't understand, that is
>criminal.

First of all - how do you _know_ that the heart attack resulted from
Advair use?  Or did you simply make an assumption?

IMO, unless there is actual evidence supporting cause-and-effect in
this particular case - coincidence is more likely.

--
"It's not American foreign policy, or the plight of the
Palestinians, or America's longstanding support for Israel.
A group of people with money and weaponry have simply
decided that we, as a civilization, are unfit to live, and
want, eventally, to exterminate us."
'Christian Century' magazine
CBI - 05 Feb 2004 19:42 GMT
> First of all - how do you _know_ that the heart attack resulted from
> Advair use?  Or did you simply make an assumption?
>
> IMO, unless there is actual evidence supporting cause-and-effect in
> this particular case - coincidence is more likely.

I've been avoiding going there but you are, of course,
correct. About 25% of cardiac disease, a leading killer,
presents for the first time with sudden death/ventricular
arryhtmia. Arrythmias from Serevent are rare. Even if the
two are temporaly related the odds are still overwhelming
that the drug had nothing to do with it.

Signature

CBI, MD

Dave - 06 Feb 2004 01:19 GMT
Colin Campbell <activated_95b@earthlink.net  (remove underscore)>
wrote in .

> First of all - how do you _know_ that the heart attack resulted from
> Advair use?  Or did you simply make an assumption?
>
> IMO, unless there is actual evidence supporting cause-and-effect in
> this particular case - coincidence is more likely.

Colon, make sure that you read my statements carefully before you make
comments like that.  I was very clear that my father did NOT have a
heart attack.  I tried to make it clear that his cardiac enzymes were
negative.  Did I lose you with such big words???

If Glaxo makes the statement that Advair can "cause a change in the
heart rhythm", and my father had a change in the heart rhythm, then
yes, I made an assumption.  The chemist from the FDA agreed with me,
that it was most likely from Advair.   Should I call him back and tell
him that you don't think so?  You must be sooooo smart.
You know, I'm starting to get sick of your ignorant comments when all
I was trying to do is point out some things that are happening, and
that many people aren't aware of.
Did you bother to read the warnings before you started taking this
medication?  I really doubt it.  Most people, including my father
don't.  I doubt that his physician did either.  It would be very
difficult to read all of the fine print that drug companies throw out
there.
CBI - 05 Feb 2004 19:39 GMT
> The warnings that come in the Advair package doesn't serve the public.

The package insert is not intended for the public. It is a
medico-legal document and so there is no reason on earth why
it shoul be worded in such a way as to allow a "layman" to
be able to read it.

> And who is to say that the benefit out weighs the risk.  NOT ME!  Not
> when you lose a loved one.

No, it was not a decision for you. It was a decision to be
made jointly by your father and his doctor. Ultimately, it
was your father's decision to take the drug every time he
did so. You keep focusing on the extremely low risk of the
drug (and I do mean extremely) while ignoring the risk of
poorly controlled.

> I hope that no one else has to go through
> what we have.

So do I. And I hope no one gets asthma, has an automobile
crash, gets cancer, has a heart attack, etc, etc.
Unfortunately I plan on being disappointed.

Signature

CBI, MD

CBI - 29 Jan 2004 03:33 GMT
> "CBI" <00_doc@mindspring.com> wrote in message

news:<4e1Kb.8418$6B.674@newsread1.news.atl.earthlink.net>...
>>> just had a friend tell me abt that, nurse in respiratory
>>  therapy told her
[quoted text clipped - 13 lines]
> Maybe YOU don't know what you are talking about.
> Serevent can kill.  The FDA makes that statement as well.  Be careful.

Dave,

I understand that you have suffered a loss and that this
issue is near to your heart. For that reason I am trying not
to get into a flame war with you. However, calling me
ignorant is simply not supported by the facts and is not
appropriate. The fact is that while Serevent does have some
cardiac risks "heart attack" is not known to be amongst
them. I understand that some people call any arrest a heart
attack but we were not discussing "99%" of people. The
person in question was a medical professional, specifically
a respiratory nurse, who should know the side effects and
risks (and the proper names for them) of this very commonly
prescribed medication.

At this point you have stated your concerns and I have
acknowledged them. I doubt that there is much more for the
two of us to say on the topic. If you do decide to continue
this discussion I would advise you that calling names while
arguing contrary obvious facts does not tend to be
persuasive.

Again, I am sorry for your loss.

Signature

CBI, MD

Dave - 29 Jan 2004 14:36 GMT
> > "CBI" <00_doc@mindspring.com> wrote in message
> >
[quoted text clipped - 38 lines]
> risks (and the proper names for them) of this very commonly
> prescribed medication.

A point well taken,,, My apologies.
Dave - 06 Feb 2004 01:41 GMT
http://www.cbsnews.com/stories/2003/12/17/eveningnews/main589058.shtml
SJF - 06 Feb 2004 15:34 GMT
> http://www.cbsnews.com/stories/2003/12/17/eveningnews/main589058.shtml

A typical example of sensationalized reporting.  I would be embarrassed to
cite such an article as a source of usable  information.  It would be
interesting to see the studies upon which this article was founded.  They,
likely, would present an entirely different view of the referenced problem.

SJF
Dave - 07 Feb 2004 04:24 GMT
> > http://www.cbsnews.com/stories/2003/12/17/eveningnews/main589058.shtml
>
[quoted text clipped - 4 lines]
>
> SJF

Don't be so lazy,,, the information is on the Glaxo web site.  Look it
up your self, unless you are emberrassed!
CBI - 07 Feb 2004 14:33 GMT
http://www.cbsnews.com/stories/2003/12/17/eveningnews/main589058.shtml

> A typical example of sensationalized reporting.  I would be
> embarrassed to cite such an article as a source of usable
> information.  It would be interesting to see the studies
upon which
> this article was founded.  They, likely, would present an
entirely
> different view of the referenced problem.

They don't list the study they are refering to but it is
pretty clearly the SMART study. And yes, most reasonable
people present it in an entirely different light.

The bottom line from what should be taken from the warnings
is two things:

1) If your asthma is so poorly controlled that you need a
constant dilator, like Serevent, then you need to be on an
inhaled steroid, like the fluticasone found in Advair.

2) If you are having a severe asthma attack - go to a doctor
and get the proper treatment. Don't just restart your
Serevent - it is not meant for the treatment if acute
attacks.

Signature

CBI, MD

Dave - 07 Feb 2004 14:38 GMT
> > http://www.cbsnews.com/stories/2003/12/17/eveningnews/main589058.shtml
>
[quoted text clipped - 4 lines]
>
> SJF

http://us.gsk.com/products/assets/us_advair.pdf
Here you go smart guy.  Look on page 19.  I would have cut and pasted
so I can spoon feed you, but it wouldn't allow it.

From everything that I've read on this site I have become a firm
believer that a few of you people believe that "Ignorance is bliss".
You have found your miracle drug, and you don't want to know that
there are serious side effects.  And how typical of a man that
"practices" his chosen profession to dispute everything that he can.
Any idea just how many deaths occur each year from the mis guidence of
their Doctor?  Why do you think malpractice insurance is so expensive.
Could be because our Dr's that can do no wrong are killing us with
their holier than thou attitudes.
It is a shame that a few of you won't open your eyes and realize that
the risk are greater than you realize.  How dare anyone point out the
fact that there is a possibility that the medication that they are
taking can be harmful.
I've said my piece,,, I'm done!
CBI - 07 Feb 2004 14:45 GMT
> From everything that I've read on this site I have become a firm
> believer that a few of you people believe that "Ignorance is bliss".
[quoted text clipped - 9 lines]
> fact that there is a possibility that the medication that they are
> taking can be harmful.

IOW - you can't refute what is being said so you just insult
the person saying it.

> I've said my piece,,, I'm done!

That is the second time you have made this promise.

Signature

CBI, MD

Bob - 07 Feb 2004 15:07 GMT
>I've said my piece,,, I'm done!

Go in peace.
ARoberts - 07 Feb 2004 17:25 GMT
> >I've said my piece,,, I'm done!
>
> Go in peace.

But go...
 
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