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Medical Forum / Diseases and Disorders / Asthma / December 2003

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Asthma medication question

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Roy Tony - 19 Dec 2003 03:48 GMT
It says on my asthma medication info. sheet: "WARNING: Ratio Salmeterol
may be associated with rare serious asthma attacks (potentialy fatal).
Some patients prescribed salmeterol when their asthma is worsening may
have an increase ricks of this event."

It then says that if the medication is not working it "may be a sign of
worsening asthma which is a serious condition"

What do they mean? Do they mean that if I use too much when it's
getting worse it's not good?  

Signature

Tony
t2k@vcn.bc.ca
ttony_at@yahoo.com

Colin Campbell - 19 Dec 2003 03:57 GMT
>It says on my asthma medication info. sheet: "WARNING: Ratio Salmeterol
>may be associated with rare serious asthma attacks (potentialy fatal).
[quoted text clipped - 6 lines]
>What do they mean? Do they mean that if I use too much when it's
>getting worse it's not good?  

Basically salmeterol (albuterol in the US) does not treat asthma - it
merely reverses one of the symptoms.  So there is a risk that the
medicine can 'cover' deteriorating asthma until it gets to the point
where the patient is in serious danger.

The rule of thumb to use id that if you are using salmeterol more than
three times a week - you need to be on other medications that will
actually control the underlying disease process.

"...there is always a well-known solution to every
human problem--neat, plausible, and wrong."
  H. L. Mencken
Roy Tony - 21 Dec 2003 23:14 GMT
>>It says on my asthma medication info. sheet: "WARNING: Ratio Salmeterol
>>may be associated with rare serious asthma attacks (potentialy fatal).
[quoted text clipped - 6 lines]
>>What do they mean? Do they mean that if I use too much when it's
>>getting worse it's not good?  

> Basically salmeterol (albuterol in the US) does not treat asthma - it
> merely reverses one of the symptoms.  So there is a risk that the
> medicine can 'cover' deteriorating asthma until it gets to the point
> where the patient is in serious danger.

I see  Thanks. I haven't used it for a while now. I noticed that if I use
Flovent (Fluticasone) according to my doctors instructions I hardly need
Salmeterol.

> The rule of thumb to use id that if you are using salmeterol more than
> three times a week - you need to be on other medications that will
> actually control the underlying disease process.

> "...there is always a well-known solution to every
> human problem--neat, plausible, and wrong."
>    H. L. Mencken

Signature

Tony
t2k@vcn.bc.ca
ttony_at@yahoo.com

CBI - 19 Dec 2003 15:07 GMT
> It says on my asthma medication info. sheet: "WARNING: Ratio Salmeterol
> may be associated with rare serious asthma attacks (potentialy fatal).
[quoted text clipped - 6 lines]
> What do they mean? Do they mean that if I use too much when it's
> getting worse it's not good?

Well, first of all - that shouldn't be an issue since Salmeterol is
not normally a medication that is increased when you are having
increased symptoms. The normal dose is twice daily and there is not
much adjustment that is normally done.

The warning stems fromt he SMART trial. The kids that showed the
increased risk of death on Salmeterol were poor black children
(interestingly - not the poor white kids - make what you will of it)
who were at baseline poorly controlled and had a low usage of inhaled
steroids.

My interpretation of this study (shared by every expert I have read on
the subject) is that if you have poorly controlled asthma then just
covering up the symptoms with Salmeterol rather than treating the
inflammation with inhaled steroids is a bad idea. If you are on
inhaled steroids or have some other condition than asthma (like
COPD/emphysema) then the results of this study (and hence the warnings
that stem from it) probably do not apply to you.  On the other hand -
if you are having poorly controlled asthma while not on inhaled
steroids and the response of your doc was to just prescribe salmeterol
then you probably need to think about that.

Your doc should be giving you guidance - preferably in the form of a
written plan - on what to do if your symptoms worsen.

Signature

CBI, MD

Roy Tony - 21 Dec 2003 23:27 GMT
>> It says on my asthma medication info. sheet: "WARNING: Ratio Salmeterol
>> may be associated with rare serious asthma attacks (potentialy fatal).
[quoted text clipped - 6 lines]
>> What do they mean? Do they mean that if I use too much when it's
>> getting worse it's not good?

When I use Flovent according to doctor instructions (which everyone
should) I hardly need Salmeterol. Once in a while if I forget to use
Flovent for more then a day, an asthma attact occurs. And then of course I
have to use Salmeterol.

My asthma usually occurs when I get out of bed in the morning, sometimes
when hungry (when stomach is growling) and when going in from a cold place
to a warm place - Usually very predictable times.  

I've had it since around 1996. But It was just last week I noticed the
scary warning on the patient information sheet provided by my pharmacis.
I swear it wasn't the before.

Tony
t2k@vcn.bc.ca
ttony_at@yahoo.com

> Well, first of all - that shouldn't be an issue since Salmeterol is
> not normally a medication that is increased when you are having
> increased symptoms. The normal dose is twice daily and there is not
> much adjustment that is normally done.

> The warning stems fromt he SMART trial. The kids that showed the
> increased risk of death on Salmeterol were poor black children
> (interestingly - not the poor white kids - make what you will of it)
> who were at baseline poorly controlled and had a low usage of inhaled
> steroids.

> My interpretation of this study (shared by every expert I have read on
> the subject) is that if you have poorly controlled asthma then just
[quoted text clipped - 6 lines]
> steroids and the response of your doc was to just prescribe salmeterol
> then you probably need to think about that.

> Your doc should be giving you guidance - preferably in the form of a
> written plan - on what to do if your symptoms worsen.
CBI - 22 Dec 2003 02:24 GMT
> I've had it since around 1996. But It was just last week I noticed the
> scary warning on the patient information sheet provided by my pharmacis.
> I swear it wasn't the before.

The study that prompted the warning was just recently published. It probably
wasn't there before.

--
CBI, MD
Arrhae - 24 Dec 2003 22:12 GMT
On 12/21/03 18:27, in article bs5a8t$rd0$1@luna.vcn.bc.ca, "Roy Tony"
<t2k@vcn.bc.ca> wrote:

> When I use Flovent according to doctor instructions (which everyone
> should) I hardly need Salmeterol. Once in a while if I forget to use
> Flovent for more then a day, an asthma attact occurs. And then of course I
> have to use Salmeterol.

Salmeterol = Serevent, comes in a teal diskus or teal inhaler.  Salbutamol =
albuterol = Ventolin, comes in a blue inhaler.  I've never heard of using
the first for an acute asthma attack...?
 
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