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Medical Forum / Diseases and Disorders / Asthma / November 2003

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Flovent  and Advair

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GRW - 26 Nov 2003 16:11 GMT
I would like to know what kind of response people have had using
either Flovent or Advair.

I have been using Flovent (220 ug / 2 x daily) for several years
(using a spacer device), along with an Advair 100 2 x daily.  I have
not gotten very good results from that and have had terrible problems
with hoarseness.

Last week my Dr. switched me to Advair 500 2 x daily.  It seems to
work better (and doesn't give me the hoarseness problem), but I don't
really understand why.

Theoretically, I was getting 1080 ug of Flovent per day (220 ug x 4
plus 100 ug x 2).  However, I read the prescribing information, and
according to the data for Flovent and Advair, the Flovent inhaler has
about a 30% absorption rate, while the Advair only has about 17%.

Therefore, at my previous dosages, I was getting 264 ug of Flovent
(220 x 4 x 30%) per day from the inhaler, plus 34 ug (100 x 2 x 17%)
from the Advair.  By changing to the Advair 500, I am actually only
getting 170 ug of Flovent (500 x 2 x 17%) which is only about half of
what I was getting before.

I know that at some level, the correct answer is "Who cares? It
works."  But unless I am mistaken in my understanding of the
prescribing information, I shouldn't be feeling better because I am
actually getting less medication.

Has anybody else had similar results, and am I mistaken in my
understanding of the information?

Thanks.
CBI - 26 Nov 2003 23:13 GMT
> I would like to know what kind of response people have had using
> either Flovent or Advair.
[quoted text clipped - 3 lines]
> not gotten very good results from that and have had terrible problems
> with hoarseness.

First of all - there is a difference in how the doseage is expressed. In the
US the doseage of puffers is epressed at that delivered out the mouthpiece.
In Europe they use the amount dispensed fromt he nozel. Therefore the
Flovent 220ug./puff in the US would be termed 250ug in Europe. The numbers
in the dry powder inhalers are more akin to the Eupropean method so to
compare apples to apples (and to make the math easier) you should probably
consider the Flovent dose to be 250/puff and the total daily dose to be
1100ug/day.

> Last week my Dr. switched me to Advair 500 2 x daily.  It seems to
> work better (and doesn't give me the hoarseness problem), but I don't
> really understand why.

I would suspect that while the doses of meds dispensed is theoretically
similar (1000/1100) that you are actually getting more with the Advair. it
may be that a larger total daily dose is making it to the lungs or that the
pattern of deposition within the lungs is more advantageous.

> Theoretically, I was getting 1080 ug of Flovent per day (220 ug x 4
> plus 100 ug x 2).  However, I read the prescribing information, and
[quoted text clipped - 6 lines]
> getting 170 ug of Flovent (500 x 2 x 17%) which is only about half of
> what I was getting before.

This is your error. When they say "absorption" the mean systemic absorption
into the blood stream (either thorugh the lungs or swallowed) - not what is
sent to the lungs.

> I know that at some level, the correct answer is "Who cares?

Well, yeah - but I understand your curiosity.

--
CBI, MD
 
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