never had added asthma and need asthma meds in complete correlation to
the
rise in particulate pollution not iron
<<

"Increased plasma iron may aggravate lipid peroxidation"

THEY found increased iron.
Particulate matter contains iron and raises oxidation / peroxidation.

Sooo .. either the increased oxidation caused by the particulate
matter OR the iron IN the particulate matter causes an increase in
OXIDATION / peroxidation IN those with asthma.

Understand .. ?

Sooo .. you 'say' it isn't the iron BUT the study says .. "if you have
asthma you have higher iron and therefore the oxidation could be a
problem" ..

By that YOU 'take home' .. ?

Oxidation / anti-oxidant balance 'may' be .. out of whack / too few
anti-oxidants to offset the oxidation.. ?

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"Subway particles to a dominating degree consisted of iron"

Chem Res Toxicol. 2005 Jan;18(1):19-23. Related Articles, Links

Subway particles are more genotoxic than street particles and induce
oxidative stress in cultured human lung cells.

Karlsson HL, Nilsson L, Moller L.

Unit for Analytical Toxicology, Department of Biosciences, Karolinska
Institutet, SE-141 57 Huddinge, Stockholm, Sweden, and Department of
Neuroscience, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

Epidemiological studies have shown an association between airborne
particles and a wide range of adverse health effects. The mechanisms
behind these effects include oxidative stress and inflammation. Even
though traffic gives rise to high levels of particles in the urban
air,
people are exposed to even higher levels in the subway. However,
there
is a lack of knowledge regarding how particles from different urban
subenvironments differ in toxicity. The main aim of the present study
was to compare the ability of particles from a subway station and a
nearby very busy urban street, respectively, to damage DNA and to
induce oxidative stress. Cultured human lung cells (A549) were
exposed
to particles, DNA damage was analyzed using single cell gel
electrophoresis (the comet assay), and the ability to induce
oxidative
stress was measured as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG)
formation in lung cell DNA. We found that the subway particles were
approximately eight times more genotoxic and four times more likely
to
cause oxidative stress in the lung cells. When the particles, water
extracts from the particles, or particles treated with the metal
chelator deferoxamine mesylate were incubated with 2'-deoxyguanosine
(dG) and 8-oxodG was analyzed, we found that the oxidative capacity
of
the subway particles was due to redox active solid metals.
Furthermore,
analysis of the atomic composition showed that the subway particles
to
a dominating degree (atomic %) consisted of iron, mainly in the form
of
magnetite (Fe(3)O(4)). By using electron microscopy, the interaction
between the particles and the lung cells was shown. The in vitro
reactivity of the subway particles in combination with the high
particle levels in subway systems give cause of concern due to the
high
number of people that are exposed to subway particles on a daily
basis.
To what extent the subway particles cause health effects in humans
needs to be further evaluated.

PMID: 15651844 [PubMed - in process]

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Tom

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