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Medical Forum / Diseases and Disorders / Asthma / April 2007Iron and respiratory impairment
J Pediatr Hematol Oncol. 2007 Mar;29(3):151-155. Links Study of Pulmonary Function Tests in Thalassemic Children.Parakh A, Dubey AP, Chowdhury V, Sethi GR, Jain S, Hira HS. Departments of *Paediatrics daggerRadio Diagnosis double daggerPathology section signRespiratory Medicine, Maulana Azad Medical College and Associated Hospitals, New Delhi, India. The present study aimed to investigate pulmonary function tests (PFTs) in children with thalassemia and to assess the relation between the degree respiratory impairment with the body iron status. High resolution computed tomography of chest (CHRCT) and bronchoalveolar lavage (BAL) was performed to study the cause of pulmonary dysfunction. Thirty-one children with thalassemia over 8 years were included. PFTs were studied including lung volumes and carbon monoxide diffusion capacity (DLco). Patients with abnormal PFTs and/or impaired DLco were further subjected to CHRCT and BAL. Total cell count was measured; differential count was performed on Giemsa and PAP smears. Iron laden macrophages were identified on Perl's stain. PFTs were normal in 51.61%, diffusion capacity impaired in 41.16%, restriction in 16.12%, while obstruction in 3.22% of cases, respectively. There was significant inverse correlation between DLco and serum ferritin. Through multivariate regression analysis, ferritin was found to be a strong predictor for forced vital capacity and total lung capacity. Bronchial dilatation and areas of air trapping were the predominant CHRCT findings. Iron laden macrophages were demonstrated in 14 of 15 patients in BAL. A significant correlation between serum ferritin and DLco, forced vital capacity, total lung capacity, and the presence of iron laden macrophages in BAL indicates that iron plays a major role in the etiopathogenesis of these abnormalities. PMID: 17356392 [PubMed - as supplied by publisher] Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk You keep posting this stuff but never post any context to why its important. Do you realize many many yg girls and infants are fed formulas with iron in it? Men are told not to take it. Are you saying that women and girls should not take it (infants also?) .. > J Pediatr Hematol Oncol. 2007 Mar;29(3):151-155. Links > Study of Pulmonary Function Tests in Thalassemic Children.Parakh A, [quoted text clipped - 39 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk >>On Mar 25, 8:09 pm, "mcs" <m...@yahoo.com> wrote: You keep posting this stuff but never post any context to why its important.<< Iron is KNOWN to increase red blood cell production .. that is WHY .. 'they' .. GIVE you iron and / or fortify your foods WITH .. iron .. Increased red blood cell production leads to respiratory distress / impairment. Decreasing red blood cell count leads to significant recovery of / from respiratory distress IE: 50% increased walking distance , 50% decrease in oxygen bottle usage. Repiratory illness is ACCOMPANIED by increased red blood cell production but .. 'they' .. tell you it is caused BY the respiratory illness and NOT the increased red blood cell production leading TO respiratory illness .. which is the way .. I .. see it. 'They' sell you a drug .. or drugs which .. coincidentally lower red blood cell count .. SPECIFICALLY used TO lower red blood cell count .. and you get better. 'They' .. say it is NOT the destruction / removal / lowering of red blood cells which CAUSE the significant .. recovery .. BUT .. the drug they SELL you .. says it .. DOES and IS .. a red blood cell .. reducer .. SPECIFICALLY. Do you realize many many yg girls and infants are fed formulas with iron in it? Men are told not to take it. Are you saying that women and girls should not take it (infants also?) ..<< This study below shows / compares the efficiency of iron in two different diet regimens .. breast feeding .. or iron supplemented formula. They both work but the most impressive of the findings IN the study are the fact .. 'they' .. seem to be ARGUING long and hard FOR iron supplementation in children using a .. marker .. which is set too high. The kids and women are / were BORN with seven months worth of iron .. and it is NEVER depleted to any appreciable amount .. and never to the point iron supplementation is .. required. We simply do not let the seven months worth of storage iron be depleted .. evidenced by the most recent studies which have found contrary to popular belief in the developing countries the .. iron deficient anemia is NOT iron deficient anemia at all but is in FACT .. the iron withholding mechanism of the body .. which withholds iron from invading pathogens . <<snip>> Although 34% of all infants had a hemoglobin concentration <110 g/L at 6 mo, the absence of iron deficiency or defective erythropoiesis suggests that this hemoglobin cutoff is too high for this age group. <<snip>> That short snip explained means .. using standard markers .. of <11 .. 34% of the infants were .. iron deficient .. but .. "we couldn't find a thing wrong with these kids and we believe these old farts have got it and have HAD IT .. wrong .. all along" .. To put it SUCCINCTLY .. Am J Clin Nutr 2002 Oct;76(4):858-64 Related Articles, Links Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides. Hernell O, Lonnerdal B. Department of Clinical Sciences, Pediatrics, Umea University, Sweden (OH), and the Department of Nutrition, University of California, Davis (BL). BACKGROUND: The appropriate level of iron fortification in infant formula remains undetermined. OBJECTIVES: We compared hematologic indexes and iron-status indicators in infants who were either breast-fed or fed formula with concentrations of 2 or 4 mg Fe/L and evaluated the effects of providing part of the iron as bovine lactoferrin and of adding nucleotides. DESIGN: Healthy term infants were exclusively breast-fed (n = 16) or fed formula (n = 10-12) from age 4 +/- 2 wk to 6 mo. Anthropometric measures were taken monthly, and blood samples were taken at 1, 4, and 6 mo. Hematologic indexes; indicators of iron, zinc, and copper status; and erythrocyte fatty acids were assessed. RESULTS: No significant differences in hematology or iron status were observed between groups at 4 and 6 mo of age. Although 34% of all infants had a hemoglobin concentration <110 g/L at 6 mo, the absence of iron deficiency or defective erythropoiesis suggests that this hemoglobin cutoff is too high for this age group. Neither the source or the concentration of iron in formula nor fortification with nucleotides had any significant effect on serum zinc or copper, and nucleotide fortification did not affect erythrocyte fatty acids. CONCLUSIONS: A concentration of 1.6 mg Fe/L formula meets the iron requirement of healthy term infants aged </=6 mo, and providing more iron does not benefit iron stores. Fortification with bovine lactoferrin or nucleotides did not benefit either iron status or erythrocyte fatty acids. Additional studies are needed to establish age-appropriate cutoffs for iron deficiency and iron deficiency anemia in infancy. PMID: 12324301 [PubMed - in process] -------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>On Mar 25, 8:09 pm, "mcs" <m...@yahoo.com> wrote: > You keep posting this stuff but never post any context to why its [quoted text clipped - 22 lines] > they SELL you .. says it .. DOES and IS .. a red blood cell .. > reducer .. SPECIFICALLY. But theophylline isn't used very much anymore. How does that affect your theory?  Signature00doc >>On Mar 28, 5:22 pm, "00doc" <0...@comcast.net> wrote: But theophylline isn't used very much anymore. How does that affect your theory?<< Why would it be less than a year someone is being **paid** to look for an alternative IF it IS so .. infrequently .. used .. ? http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/10-26-200 6/0004460284&EDATE= Oct. 26 / 06 The goal of the asthma grant is to develop a selective blocker of the adenosine A2B receptor (A2BAR) that could replace theophylline, a non-selective adenosine blocker, in the treatment of asthma. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>On Mar 28, 5:22 pm, "00doc" <0...@comcast.net> wrote: But theophylline isn't used very much anymore. How does that affect your theory?<< I suppose the .. **markup** / commission ON this drug would be pretty .. low .. as compared to the .. newer drugs. Which most likely would be THE.. motivating factor as to its' .. disuse .. ? The doctor **himself** would not be .. **pocketing** .. very much cash WHEN prescribing theophylline .. ? .. or one of the other more expensive .. alternatives. The Mayo Clinic and Canadian Lung Association seem to still use it. http://www.mayoclinic.com/health/asthma-treatment/AS00011 Theophylline (Uniphyl). This drug is taken in pill form, either alone or in conjunction with an inhaled corticosteroid. Although guidelines include it as an alternative to a long-acting beta-2 agonist in mild persistent and moderate persistent asthma, theophylline is rarely used in children. http://www.ah.com/Article.asp?doc=14 Controller Medication - Theophyllines Theodur®, Slo-Bid®, Uniphyll® These drugs are bronchodilators that relax the muscles surrounding the airways. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > The Mayo Clinic and Canadian Lung Association seem to still use it. Several of my Dr's over the years have stopped prescribing Theophylline. All of them have stated that the difference between therapeutic dosage and harmful dosages is too narrow and thus requires constant monitoring. They seem to feel its just not worth it. I was on Theophylline in the early 90's but no Dr of mine has even mentioned it since. Iron Does anyone back up your argument. Before iron was stopped being recommended for men, I use to take vitamin with iron for long time. Now assuming your correlations are correct, does this buildup inside body or can body rid itself eventually of excess iron? If so it hasn't worked for me as I obviously have asthma and don't take iron. I don't pretend to suggest that its not possible what your saying is correct as I believe from what I have seen with acceptance of particulate pollution and a host of horrible correlations that I would swear on a stack of bibles is correlated, anything else is possible. I have given evidence of the correlations and consequences. Can you show me studies suggesting what you suggest is correct and why other people have not sued those recommending girls and women and babies to still take it? Can you show anyway or shape or form that babies taking iron formula for example do worse with more asthma then those that don't? Why can't people sue if correct? >>>On Mar 25, 8:09 pm, "mcs" <m...@yahoo.com> wrote: > You keep posting this stuff but never post any context to why its [quoted text clipped - 133 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk Iron Does anyone back up your argument. << Noone .. >>Before iron was stopped being recommended for men, I use to take vitamin with iron for long time. Now assuming your correlations are correct, does this buildup inside body or can body rid itself eventually of excess iron? << Imagine .. You are BORN with a 'set' amount of iron given to you by your mom at birth .. seven months worth of stored iron. You NEVER .. 'deplete' THIS iron .. to any great extent. You just keep this seven months worth .. topped up. You are going to die with the same iron your mom gave you .. this seven months worth of stored iron. Your body normally absorbs VERY LITTLE iron. It just absorbs or ATTEMPTS to just absorb a wee bit just to OFFSET the .. wee bit .. you sweated out the day before .. about a milligram. You normally downregulate the absorption of iron from your meals just to offset what you sweated out from the day before. Now since we are BOMBARDED with iron in all forms .. exhaust , wood smoke , cigarette smoke , EVERY piece of floured product you eat has iron added to it .. Now we can control ALL iron from all .. sources .. BUT .. from blood / meat. This iron is absorbed at all times and it upregulates OTHER iron when ingested with it and this means you NOW absorb MUCH more iron from your .. high iron beans .. Sooo .. the fact you ingested vitamins with iron AND ate meat means you have absorbed MUCH more iron than that guy who never ingested iron supplements. This iron .. or the average meat eating joes iron would not be depleted on a vegetarian diet .. for over seven years .. Soo .. the body CAN expell this iron .. but it takes a relatively long time. THAT is WHY .. phlebotomy / bloodlettting is recommended .. it lower the iron levels quickly. Some of the iron depletion people are going in for .. three .. blood donations a week. >>If so it hasn't worked for me as I obviously have asthma and don't take iron. I don't pretend to suggest that its not possible what your saying is correct as I believe from what I have seen with acceptance of particulate pollution and a host of horrible correlations that I would swear on a stack of bibles is correlated, anything else is possible. I have given evidence of the correlations and consequences.<< Yes .. but the lung has specialized methods of DEALING with .. particulates .. they can be .. absorbed and expelled. ONLY though .. IF .. the system is NOT .. compromised .. as in the ABILITY of the bodies .. metal **chelating** abilities. >>Can you show me studies suggesting what you suggest is correct and why other people have not sued those recommending girls and women and babies to still take it? << You would be suing yourself .. the government .. The government is someone not to be trifled .. with. Serious .. "We will hit you with so many potential legal bills you will literally sht yourself" .. The studies are pretty much .. leading edge. They are only now realizing the implications of this mistake. It hasn't been very long since they have realized there is more than one thing that controls red blood cell production. They have argued since the beginning of time that ONLY hypoxia / lack of oxygen / oxygen sensing 'switch' .. is what 'governs' .. red blood cell PRODUCTION and "only" .. this "switch" .. when in fact they have now shown .. IRON.. to do it all on its' .. own. That is why injecting iron works .. good .. >>Can you show anyway or shape or form that babies taking iron formula for example do worse with more asthma then those that don't? Why can't people sue if correct?<< You would think if kids grow poorly .. it may affect their asthma .. ? By .. "growing poorly" .. would mean .. they killed them. http://www.scidev.net/content/news/eng/iron-supplements-increase-mala... MILLIONS of dead malaria stricken babies , MILLIONS of premature babies , http://www.eurekalert.org/pub_releases/2006-05/chr-cho053106.php Here's the results of giving iron to kids who are NOT .. iron deficient .. Growth retardation .. <<snip>> Among the Swedish infants, gains in length and head circumference were significantly lower in those who received iron than in those given placebo from 4 to 9 mo. The same effect on length was seen in Honduras, <<snip>> Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in sweden and honduras. Dewey KG, Domellof M, Cohen RJ, Landa Rivera L, Hernell O, Lonnerdal B Department of Nutrition and Program in International Nutrition, University of California, Davis. Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. Medicina Infantil, San Pedro Sula, Honduras. [Medline record in process] Iron supplements are often prescribed during infancy but their benefits and risks have not been well documented. We examined whether iron supplements affect growth or morbidity of breast-fed infants. Full-term infants in Sweden (n = 101) and Honduras (n = 131) were randomly assigned to three groups at 4 mo of age: 1) placebo from 4 to 9 mo; 2) placebo from 4 to 6 mo and iron supplements [1 mg/(kg. d)] from 6 to 9 mo; or 3) iron supplements from 4 to 9 mo. All infants were exclusively or nearly exclusively breast-fed to 6 mo and continued to be breast-fed to at least 9 mo. Growth was measured monthly and morbidity data were collected every 2 wk. Among the Swedish infants, gains in length and head circumference were significantly lower in those who received iron than in those given placebo from 4 to 9 mo. The same effect on length was seen in Honduras, but only at 4-6 mo among those with initial hemoglobin (Hb) >/=110 g/L. There was no significant main effect of iron supplementation on morbidity, nor any significant interaction between iron supplementation and site, but for diarrhea (with both sites combined), there was an interaction between iron supplementation and initial Hb. Among infants with Hb < 110 g/L at 4 mo, diarrhea was less common among those given iron than in those given placebo from 4-9 mo, whereas the opposite was true among those with Hb >/= 110 g/L (P < 0.05). We conclude that routine iron supplementation of breast-fed infants may benefit those with low Hb but may present risks for those with normal Hb. PMID: 12421836, UI: 22309240 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk |
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