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Medical Forum / Diseases and Disorders / Asthma / September 2006Striking findings of increased iron and lipid peroxidation / asthma
<<snip>. possible potential indicators of this airway disease <<snip>> Biol Trace Elem Res. 2006 ;111:41-52 [Pubmed] [Scholar] [Select] [Drop] [Hide] [Show] Plasma paraoxonase activities, lipoprotein oxidation, and trace element interaction in asthmatic patients. Ozlem Balci Ekmekci, Orkide Donma, Hakan Ekmekci, Nurhayat Yildirim, Omer Uysal, Emine Sardogan, Hande Demirel, Tuncalp Demir Paraoxonase (PON1) protects low and high-density lipoproteins (LDL and HDL) against oxidation induced by reactive oxygen species formation facilitated by iron (Fe) and copper (Cu) ions. Plasma PON1, arylesterase, oxidized LDL (Ox-LDL), Cu, Fe, thiobarbituric acid-reactive substances (TBARS), lipid, lipoprotein, and apolipoprotein profile in bronchial asthma were determined and the relations among these parameters in different steps of asthma were interpreted. A total of 58 individuals, 30 asthmatics and 28 controls, were included into the scope of this study. Plasma PON1, arylesterase, and TBARS levels were measured spectrophotometrically. Determination of plasma oxidized LDL, Cu, and Fe levels were performed by enzyme-linked immunosorbent assay, atomic absorption spectrophotometry, and the automated TPTZ method, respectively. Apo-A-1 and Apo-B levels were determined immunoturbidometrically. Plasma total cholesterol, triglyceride, and HDL cholesterol levels were enzymatically determined. Plasma LDL levels were estimated using the Fridewald formula. The average plasma PON1 and arylesterase activities in the group of patients were lower than those of the individuals in the control group, but there was no statistically significant difference found between them (p > 0.05). No significant difference was found in plasma Apo-A-1, Apo-B, total cholesterol, triglyceride, HDL, and LDL concentrations between the control and patient groups (p > 0.05). Plasma oxidized LDL (p < 0.05), Cu (p < 0.01), Fe (p < 0.01), and TBARS (p < 0.001) levels in patients with asthma were found to be significantly higher than for the control group. Increases in Cu, Fe, lipid peroxidation, and oxidized LDL levels supported by relative decreases in PON1 activities observed in asthmatic patients might be introduced as the striking findings as well as the possible potential indicators of this airway disease, the prevalence of which has increased dramatically over recent decades. Biol Trace Elem Res. 2006 ;111:23-30 Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "Striking findings of increased iron and lipid peroxidation" Gee, what a suprise! I've only been saying this for several years now here. um can you decipher that in plain english? > "Striking findings of increased iron and lipid peroxidation" > > Gee, what a suprise! I've only been saying this for several years now > here. >>mcs wrote: um can you decipher that in plain english?<< This is the .. relevant .. portion .. <<snip>> Increases in Cu, Fe, lipid peroxidation, and oxidized LDL levels supported by relative decreases in PON1 activities observed in asthmatic patients might be introduced as the striking findings as well as the possible potential indicators of this airway disease. <<snip>> S-i-m-p-l-y .. put .. Copper {Cu] and Iron {Fe] .. are oxidizers .. they destroy antioxidants .. they cause oxidative stress .. http://www.genox.com/what.htm Lipid peroxidation Definition: The process whereby free radicals "steal" electrons from the lipids in our cell membranes, resulting in cell damage and increased production of free radicals. Oxidizers such as .. copper .. and .. iron .. cause free radicals .. PON1 is an antioxidant .. and it is .. depleted .. All of the above point to oxidation .. BEING .. 'present' .. IN .. 'those with asthma' .. Sooooo .. they are saying .. "we believe these in PARTICULAR .. copper .. iron .. lipid peroxidation .. and decreased PON1 .. can be used to TELL {potentially indicate] whether or not one 'has' / diagnosis .. asthma .." .. 'Striking' means .. to hit .. to picket against a perceived fairness inequality or in this .. case .. "holy sht" .. IMHO .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk look what does that mean? That people are not taking or getting adequate amounts of iron and this is precipitating more asthma? Seriously I am not doubting that as a reason but certainly I have my own reasons. Go to alt lawyer. for why I think pollution is the single biggest reason for adult onset asthma and probably illness in general in the US except for maybe smoking and diet... >>>mcs wrote: um can you decipher that in plain english?<< > [quoted text clipped - 49 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk >"Striking findings of increased iron and lipid peroxidation" >Gee, what a suprise! I've only been saying this for several years now >here. Thanks, I was looking for that word to add to my kill filter :) Ralph again does this mean iron is good or bad for people with asthma? > <<snip>. > possible potential indicators of this airway disease [quoted text clipped - 50 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk Totally irrelevant question to ask a crackpot who thinks all disease is caused by iron! > again does this mean iron is good or bad for people with asthma? > [quoted text clipped - 52 lines] > > DEAD PEOPLE WALKING > > http://tinyurl.com/zk9fk > again does this mean iron is good or bad for people with asthma? > [quoted text clipped - 52 lines] > > DEAD PEOPLE WALKING > > http://tinyurl.com/zk9fk Lactoferrin is an .. iron binder .. and it is produced in our bodies .. and when this protein is 'overloaded' .. saturated with iron .. it cannot do its' .. job .. Sooo .. is the 'treatment' .. 'emptying' our naturally occuring / produced lactoferrin .. so it can NOW .. do its' .. job .. ? When INTRODUCED .. it seems it is .. effective in **reducing** .. asthma and allergy .. symptoms .. <<snip>> We postulate that **free iron** in the airways <<snip>> Lactoferrin decreases pollen antigen-induced allergic airway inflammation in a murine model of asthma. Kruzel ML, Bacsi A, Choudhury B, Sur S, Boldogh I Immunology. 2006 Jun 26; Pollen grains contain reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidases and in contact with mucosal surfaces generate superoxide anion (O(2) (*) (-)). In the presence of iron, O(2) (*-) may be converted to more reactive oxygen radicals, such as to H(2)O(2) and/or (*)OH, which may augment antigen-induced airway inflammation. The aim of the study was to examine the impact of lactoferrin (LF), an iron-binding protein, on ragweed (Ambrosia artemisiifolia) pollen extract (RWE)-induced cellular oxidative stress levels in cultured bronchial epithelial cells and accumulation of inflammatory and mucin-producing cells in airways in a mouse model of allergic airway inflammation. Results show that LF lowered RWE-induced increase in cellular reactive oxygen species (ROS) levels in bronchial epithelial cells. Most importantly, LF significantly decreased accumulation of eosinophils into airways and subepithelium of intranasally challenged, sensitized mice. LF also prevented development of mucin-producing cells. Amb a 1, the major allergenic ragweed pollen antigen lacking NAD(P)H oxidase activity, induced low-grade airway inflammation. When administered along with glucose oxidase (G-ox), a superoxide-generating enzyme, Amb a 1 induced robust airway inflammation, which was significantly lowered by LF. Surprisingly, LF decreased also inflammation caused by Amb a 1 alone. Iron-saturated hololactoferrin had only a marginal effect on RWE-induced cellular ROS levels and RWE- or Amb a 1 plus G-ox-induced inflammation. We postulate that free iron in the airways chemically reduces O(2) (*) (-) to more reactive species which augment antigen-induced inflammation in a mouse model of asthma. Our results suggest the utility of LF in human allergic inflammatory disorders. Abstract · PubMed FullText · SFX · GS Clip Export InterDB · Terms Related · Graph Cites · Scopus · Tag Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Yup, oxygen again, it is the cause of all disease. Jesus was a fish eater. |
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