 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Asthma / March 2006Blocking Eotaxins May Help Asthmatics Breathe Easier
Link To Article: http://www.jci.org/cgi/content/full/116/1/228#ABS Asthma is an inflammatory disorder of the airways, characterized by periodic attacks of wheezing, shortness of breath, chest tightness, and coughing. Treatment is aimed at avoiding known allergens and respiratory irritants and controlling symptoms and airway inflammation through medication. To gather more information on Asthma, its symptoms, & about its treatment just visit link below:- http://medical-health-care-information.com/encyclopedia/A/Asthma.asp > Asthma is an inflammatory disorder of the airways, characterized by > periodic attacks of wheezing, shortness of breath, chest tightness, and [quoted text clipped - 7 lines] > > http://medical-health-care-information.com/encyclopedia/A/Asthma.asp Whoosh.... > Link To Article: > > http://www.jci.org/cgi/content/full/116/1/228#ABS Ummmmmm.............. Could you explain what the heck that article said, in English? I still haven't figured out what an Eotaxin is. It could possibly be that I'm really tired, but it looked like Mandarin Chinese. I hardly understood a word. Maybe I need more coffee? Life is uncertain............eat dessert first!! Nancy 8=: ) >> Link To Article: >> [quoted text clipped - 13 lines] > Nancy > 8=: ) Sorry about that; it took me a while to wade through it too. Distilled to its essence: Elevated plasma eotaxin (a cytokine) appears to be a marker for asthma. Nerves in the lungs release eotaxin, a substance that attracts eosinophils to the nerves. The eosinophils stimulate the nerves to release acetylcholine (related to methacholine--remember the challenge test) which narrows airways They are proposing that blocking eotaxin and eosinophil interaction could be helpful in treating asthma. There's more, but today, I'm a little groggy too. Much of this article dealt with their metholology of how they demonstrated their hypothesis by subjecting guinea pigs to various challenges, and performing dissection of airway tissues to assess the effects of various challenge chemicals and their antagonists. Here are some additional, less technical expositions of this: http://tinyurl.com/s4pla http://tinyurl.com/oyraq http://tinyurl.com/qulml >>>Link To Article: >>> [quoted text clipped - 27 lines] > performing dissection of airway tissues to assess the effects of various > challenge chemicals and their antagonists. Thanks. The other links helped too, it was much easier to understand. It's funny, the correlation between losing weight and asthma. I have always considered that to be such a vicious circle. I've been taking prednisone for years, and between that, the inhaled steroids and all the other crap I take, it has been impossible for me to lose weight. Even though I eat very healthy, between the meds and not being able to do an incredible amount of exercise, how the hell am I supposed to lose the weight that will help me not wheeze? One of those connundrums. Oh well. Interesting article though. Life is uncertain............eat dessert first!! Nancy 8=: ) >>>>Link To Article: >>>> [quoted text clipped - 43 lines] > Nancy > 8=: ) I know, I was having the same thoughts as I was posting the article. Great idea, but how does that work when prednisone is in the picture? Now, if there were a nice substitute for prednisone... Usually the suffix -taxin has something to do with somethign moving (as in what a taxi does for you). The Eo- part refers to eosinophils, the white blood cell type most associated with asthma and allergies. I think the main take home message is that they have identified a soluble protien (eotaxin floating in the blood) which is involved in asthma. Presumably this would be a good target for a new class of drugs. If you could identify an eotaxin receptor and block it then you would have a good asthma (and presumably allergy) medication.  Signature00doc >Usually the suffix -taxin has something to do with somethign moving (as >in what a taxi does for you). The Eo- part refers to eosinophils, the >white blood cell type most associated with asthma and allergies. >I think the main take home message is that they have identified a >soluble protien (eotaxin floating in the blood) which is involved in >asthma. Presumably this would be a good target for a new class of >drugs. If you could identify an eotaxin receptor and block it then you >would have a good asthma (and presumably allergy) medication. One of the intriguing aspects of this area of study is the correlation between obesity and asthma. Eotaxin (and other inflammatory mediators) levels are reduced when weight is reduced, and consequently, airway reactivity. > >Usually the suffix -taxin has something to do with somethign moving (as >>in what a taxi does for you). The Eo- part refers to eosinophils, the [quoted text clipped - 10 lines] > levels are reduced when weight is reduced, and consequently, airway > reactivity. We are gradualy learning that adipose tissue is not just an inert storage depot. It is actually a very endocrinologically, if not metabolically, active tissue. It secretes many inflammatory mediators and hormones that have wide effects. Basically, being fat is an inflammatory condition. Signature00doc |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2009 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.