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Medical Forum / Diseases and Disorders / Asthma / March 2006

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asthma or infection

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michael - 03 Mar 2006 00:41 GMT
Hello  all....

W ell after 2 hospitalizations I'm still wheezing and congested also not a
happy camper....it started aprox 4 months ago I went into hospital for 9
days on iv zyvox, medral, avalox...released on 40 mg prednisone and 600 mg
zyvox tabs 2x dailyfor 10 more days  ...felt great evev after reducing
prednisone to 10 mg daily over 3 weeks next 2 weeks were the best then a
sinus congestion over the next 2weeks .....then the lungs started again
....30 days later the doctor gave me 10 days zyvov after much beggin by me
started clearing about 5 days into it but doctor wouldnt give more zyvox
...it was back downhill , both sinus and lungs ....i started herbs salt
almost anything that might help...helped me feel better sinus wise as was
irrigating with a new home mixture and able to sniff well..however the lungs
were not good.....2 weeks i had broncoscopy then next day sinus
surgery....sinus doctor  says all looked good infection wise but i was
plugged with thick mucus up top , which he removed also  says to tell lung
doctor that sinus issues are not causing lung  problems....

follow up  with lung doc end of that week ...doctor says lungs clear of
infection and my only hope is zolair which my insurance had turned down
saying i'm ok on prednisone...or something cide he says is a chemo therapy
drug...the following week my primary care doctor called asking about the
mrsa the lab reports show from the broncoscopy wash out..i said i knew
nothing about it as  the lung doctor said all was good......the pc doctor
has started me on zyvox 600mg 2x daily for 28 days and 40 mg prednisone
daily  without wanting to discuss lung doctor........
i'm 4 days on zyvox confused and frustrated ,  trying to be well but stuck
in the mud.....any advise please....mahalo  michael
MikeV - 10 Mar 2006 15:41 GMT
Michael:
Some months ago I quoted similar problems that my 55 year old sister
in law was having at the nexus between various difficult infections
and asthma/COPD.
She is not HIV but has had many of the infections associated with
HIV.
I am far from being expert or even knowledgeable in this, but it
appears that her immune system may have become so compromised as a
result of years of overmedication with prednisone, that she is no
longer able to make her own gamma globulin. She is being given
regular injections of gamma globulin, but inevitably she still has
frequent emergencies with infections. She constantly depends on
oxygen.
She was even considered for lung-transplant, but it was considered
very unlikely that she would survive the surgery.
I hope that your internist is monitoring you appropriately in this
area.

Note: I am not an asthma patient myself, but would appreciate
comments from 00Doc et al. on this, especially on the likelihood of
her recovering any immune function in the long term.
Good luck.
MikeV

> Hello  all....
>
[quoted text clipped - 27 lines]
> i'm 4 days on zyvox confused and frustrated ,  trying to be well
> but stuck in the mud.....any advise please....mahalo  michael
00doc - 10 Mar 2006 22:17 GMT
To my knowledge prednisone usually doesn't cause hypogammaglobulinemia
but certainly will increase the immunosuppression that to brings.
Other immunosuppressive drugs can do it so it is possible I am wrong on
that one.

I guess the easy answer to the question of how likely it is that she
will recover is that it would depend on why the globulin levels or so
low in the first place. Unfortunately, I can't think of many causes
that would be commonly reversible so from the little I know I would
have to say it is not good.

Here is an article on it. It gets technical at times but I think if you
skip all the stuff about congential syndromes and scroll down to the
paerts about acquired (or secondary) disease there is some sueful
information:

http://www.emedicine.com/med/topic1120.htm

Sorry I can't  get more detailed right now. I'm on my way out for the
week-end.

Signature

00doc

MikeV - 14 Mar 2006 16:31 GMT
Thanks for the response.
Depressing.
Apparently there are docs who will prescribe LDN. Long odds, but
what's to lose?.
http://www.medicalnewstoday.com/medicalnews.php?newsid=24945
http://www.ldninfo.org/
Low LDN Dose Successfully Treats HIV/AIDS, Cancer and MS by
Strengthening Immune System

Main Category: Immune System/Vaccines News
Article Date: 23 May 2005 - 9:00am (UK)

A very low dose of the FDA-approved drug naltrexone has been
discovered to be an effective up-regulator of the immune system. The
new therapy, called low dose naltrexone (LDN), has shown remarkable
effects on an array of illnesses including HIV/AIDS, cancer, and
autoimmune diseases such as MS. The first conference concerning LDN
will be held on June 11th at the New York Academy of Sciences in
Manhattan. Recent clinical trials of LDN will be discussed.

New York, NY (PRWEB) April 18, 2005 -- The drug naltrexone, which in
a 50 mg dose was approved by the FDA many years ago for drug abuse
and for alcoholism, in less than one-tenth that dosage boosts the
immune system and thus helps fight any disease that is characterized
by inadequate immune function.

Investigators mounting successful clinical trials, along with
physicians and patients utilizing low dose naltrexone (LDN), will
make panel presentations on June 11th at a conference to be held at
the New York Academy of Sciences. The keynote speaker will be
Bernard Bihari, MD, a Manhattan physician and the discoverer of the
clinical effects of LDN. This discovery establishes a new paradigm
in medical therapy: LDN not only tends to normalize the immune
system by elevating the body's endorphin levels but also
accomplishes its results with virtually no side effects or toxicity.

Two pilot studies have recently been completed, one for Crohn's
disease and one for multiple sclerosis (MS), and the principal
investigators, respectively from Hershey Medical Center at Penn
State and from Dr. Evers Clinic, a hospital for neurological disease
in Germany, will be present.

The promise of LDN is significant because: (a) it can halt diseases
(e.g., MS and other autoimmune diseases, HIV, and many cancers)
where there are no effective treatment options; (b) it provides
successful treatment while being virtually free of side effects or
toxicity; and (c) were it produced in a developing country, this
generic drug would offer an extremely inexpensive ($10 per year) HIV
treatment, one that does not require close supervision by health
professionals-the patient need only take one small capsule each
night at bedtime.

The conference will be held on June 11, 2005 from 9am to 4pm at the
New York Academy of Sciences, located at 2 East 63rd Street, between
Fifth and Madison Avenues in Manhattan.

For additional information, comprehensive details regarding LDN are
provided at http://www.ldninfo.org. The website
http://www.remedyfind.com includes independent ratings of LDN by
people with MS, who rank it far higher than any other MS medical
treatment; and http://ldners.org/surveys.htm displays results of
surveys of hundreds of people with MS, who are reporting striking
reductions in disease progression as well as marked functional
improvement on LDN alone.

Contact Information:
David Gluck, MD
212-734-5109
http://www.ldninfo.org

N.B.: Interested media representatives should register to attend
this conference as soon as possible in order to assure a reserved
seat.

> To my knowledge prednisone usually doesn't cause
> hypogammaglobulinemia
[quoted text clipped - 25 lines]
> the
> week-end.
00doc - 14 Mar 2006 19:15 GMT
Wonderful. Just what we need. Another one cause wonder.

Don't get me wrong - I have no idea of it works in this way so I am
certainly not saying that it doesn't. I doubt claims of establishing a
new paradigm of treatment and being successful in treating HIV, MS, etc
etc can really be substantiated. At best there is preliminary work
suggesting it has promise.

It would just be nice if you didn;t respond to every single post with
the same tired message. By now I think we all get it.
MikeV - 14 Mar 2006 22:46 GMT
> Wonderful. Just what we need. Another one cause wonder.
>
[quoted text clipped - 10 lines]
> with
> the same tired message. By now I think we all get it.

I wonder if you are confusing me with someone else? I am not clear
on what the repeated tired message is that you are "all getting"?.
LDN is *brand new* to me, and I was hoping for a little positive
information about it. Admittedly, not very optimistically.

My sister in law seems currently close to death, and in the absence
of lifebelts, I am down to grasping at straws on her behalf.
May I pass on your kind regards?

Gratefully
MikeV
michael - 11 Mar 2006 08:21 GMT
Aloha  mikev

......I was mis-diagnosed with asthma for an mrsa bacteria infection and
treated for 3.5 years with no improvement ... I have been on high dose
prednisone for 4 years now which caused problems with my immune system and
infections .....I have been reading about
good results from a low dose of naltrexone enabling the immune system to
rebuild ,  if we can recharge the immune system our body will have a better
chance to heal......Here is a  link
http://www.lowdosenaltrexone.org/index.htm

    Mahalo  Michael

> Michael:
> Some months ago I quoted similar problems that my 55 year old sister in
[quoted text clipped - 45 lines]
>> i'm 4 days on zyvox confused and frustrated ,  trying to be well but
>> stuck in the mud.....any advise please....mahalo  michael
MikeV - 11 Mar 2006 17:44 GMT
Hi Michael:
Seems like you have interesting parallels with my sister in law
Cathy.
Low dose naltrexone sounds interesting. The problem maybe that it is
a slow moving treatment, and solid experimental results could take
years?
Please let us know the reactions of your doctors, (and possibly more
importantly, those of the insurance company "diagnosticians" :-) )
I believe Cathy's internist is an AIDS doctor, so it would more than
likely be within his awareness or perhaps even experience. I will
try to get his take.
Any insights from 00doc please?
MikeV

> Aloha  mikev
>
[quoted text clipped - 65 lines]
>>> i'm 4 days on zyvox confused and frustrated ,  trying to be well
>>> but stuck in the mud.....any advise please....mahalo  michael
 
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