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Medical Forum / Diseases and Disorders / Asthma / November 2005

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Another New Asthma drug in Times 7/11/2005

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Robin - 08 Nov 2005 23:09 GMT
Anyone come across Xolair, an IgE antibody blocker? Apparently been
licensed today as a groundbreaking new treatment. See The Times or the
article at http://www.timesonline.co.uk/article/0,,8122-1861281,00.html
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Robin

Richard Friedel - 10 Nov 2005 08:04 GMT
We've been hearing about "groundbreaking"  (see article) new asthma
treatments  for time immemorial.  Who can overlook the  psychological
"holy grail" tactic?  Apart from anything else, surely this goes to
show that something's wrong somewhere and that the only answer is a
more realistic view of the activities of  the pharma, as based on the
expectations of patients allowing themselves to be pushed into a
captive market.

Couldn't much more be done to save people by getting an awareness of
the role of panic in asthma and of the vicious circle of
hyperventilation and airway narrowing than all the hot but stereotype
research news which journalists have such an insatiable appetite?
Regards, Richard Friedel
ARoberts - 10 Nov 2005 12:05 GMT
> We've been hearing about "groundbreaking"  (see article) new asthma
> treatments  for time immemorial.  Who can overlook the  psychological
[quoted text clipped - 9 lines]
> research news which journalists have such an insatiable appetite?
> Regards, Richard Friedel

Then research and insight into the mechanisms underlying the disease is a
bad thing?  What we really need is more awareness of long-existing breathing
techniques?  It's an education problem, not a medical problem.  Please.
00doc - 10 Nov 2005 13:13 GMT
Its all in your head, silly.

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00doc

shorteze@msn.com - 10 Nov 2005 14:25 GMT
It probably cured asthma in the study,but the drug companies realized
they would lose too much money and halved its power :p.
Richard Friedel - 11 Nov 2005 08:52 GMT
Depends on whether you believe in a key or primary role of lung tissue
damage.  Exercises for slowing down my breathing rate quickly converted
me from being a true believer in asthma drugs.  Breathing controls
supposedly fundamental things like the lungs' allergic response.
Asthma can be caused by reflux (GERD) and this doesn't fit in with the
primacy of lung damage stuff either.
Normally Occam's Razor (concentrating on the simplest argument first)
would apply, but the technicalities of medicine prevent this.  Apart
from people expecting pills etc and not instruction in breathing
techniques from a doctor, the key aspect of breathing, that is
sufficiently doctor-friendly, is measuring air breathed in and out.
Pulse oximetry is tied up with this central concept. Peakflow
measurements are of course in the present state of affairs essential to
save lives, but seem to exclude a concentration on routines such as
pursed lip breathing, which - obviously - increase pressure in the
abdomen like karate maneuvers and hence the flow of blood to the lungs
(Frank-Starling mechanism) by squeezing the vena cava inferior.
Other breathing-related things like chi, prana, getting a feeling for
the "tanden" and pressure in the abdomen pass the Occam's Razor
test but cannot be measured, because they are felt as sensations and
seem to be dependent on the culture you happen to live in.
So studying the details of lung tissue damage would not seem to help,
but rather hinder, getting a fuller picture of asthma.
Sifting the evidence from all sources including oriental breathing
techniques would seem to point to asthma being dependent on a lack of
sufficient blood in the lungs.  If too much air in the lungs
(hyperventilation) is a key symptom of asthma, then it would be obvious
to try to increase the so unfortunately non-measurable lung blood
supply.  Buteyko has shown that simply reducing the air supply rate
(demonizing deep breathing) is merely a symptomatic approach.
Leaving out the safety aspect, tensing the front upper abdominal
muscles inward and upward while slowly breathing in seems to unlock the
chest.  The shoulders can move up naturally and there is a sort of
bronchodilator sensation at the top of the chest. The heart seems to
pump more blood. Either a real increased blood flow into the lungs or
some reflex is concerned.
All this  however must necessarily be banned from medicine (but not
from physiotherapy) because the factors involved cannot be truly
identified, let alone measured.  Regards, Richard Friedel.
 
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