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Medical Forum / Diseases and Disorders / Asthma / November 2005Acidosis / oxidative stress / free iron
In acute ICU asthma related attack .. the procedure is to administer .. bicarbonate .. Coincidence .. ? Would / could the bicarbonate administered in ICU .. now .. lower the free iron which is catalyzing .. oxidation .. thereby decreasing the oxidative stress / free iron in the .. host .. ? Iron release in the body is accomplished by lowering the ph into acidity which causes the iron to become .. disassociated. Transfusion. 2005 Nov;45(11):1768-73. Links Bicarbonate inhibits the growth of Staphylococcus epidermidis in platelet concentrates by lowering the level of non-transferrin-bound iron. Matinaho S, Karhumaki P, Parkkinen J. >From the Finnish Red Cross Blood Service, Helsinki, Finland. BACKGROUND: Platelet concentrates (PCs) contain non-transferrin-bound iron (NTBI) owing to the displacement of iron from plasma-derived transferrin by citrate. NTBI in the PC medium supports the growth of Staphylococcus epidermidis. The possibilities of lowering the level of NTBI have been studied with the aim to inhibit the growth of S. epidermidis in the PC medium. STUDY DESIGN AND METHODS: NTBI in PC supernatants was determined by a chelation method and by the bleomycin-detectable iron assay. Iron binding by transferrin was determined by spectrophotometry. The growth of inoculated S. epidermidis in PC supernatants was monitored by optical density and determination of viable counts. RESULTS: Bicarbonate enhanced in a dose-dependent manner transferrin iron binding in citrate-containing solutions, including citrated plasma and PAS-II. The use of a modified anticoagulant supplemented with bicarbonate effectively lowered the level of NTBI and inhibited bacterial growth in citrated plasma. Supplementation of bicarbonate to the additive solution to increase the ratio of bicarbonate to citrate in a reconstituted PC medium further inhibited bacterial growth. Maintenance of stable pH and bicarbonate level in the reconstituted medium necessitated storage under 5 percent CO(2). CONCLUSIONS: The relatively low bicarbonate level in PC medium promotes iron displacement by citrate from plasma-derived transferrin. The appearance of NTBI can be decreased and iron-dependent bacterial growth can be inhibited by increasing bicarbonate level in citrated plasma and PC medium. To achieve the same beneficial effect in blood banking, other more practical ways to bind NTBI in a harmless form should be developed. PMID: 16271102 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking No, because the body has a very finely tuned system for maintaining ph at all times, crack medical "researcher" you are this should have been basic knowledge. But since you didn't, we must then conclude something about your abilities, no? Low iron is known to cause problems in mental abilities and learning etc. and it is a good guess we have it confirmed, no? What part of staying off my threads don't you understand .. ? You are useless in the medical newsgroups .. You don't know a thing about .. physiology .. AGAIN .. evidenced by your stupidity .. Acidosis is KNOWN to happen .. The FACT you don't .. seem .. to .. KNOW .. that .. means .. what .. ? That you are .. stupid .. ? Name two environmental influences which cause the body to go .. acidic .. Comeon .. think hard .. Heh .. heh .. But since you didn't, we must then conclude something about your abilities, no?<< Shouldn't call people stupid .. when .. in fact .. it is yourself .. who is .. stupid .. Cold and hot .. There you learned something .. So what would the next step BE .. as a .. researcher .. ? See if cold or hot come into the .. scenario .. ? Does hot or cold exacerbate the .. asthma .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking <<snip>> It is concluded that in more than 50% of the cases respiratory acidosis of severe acute asthma is associated with a metabolic acidosis <<snip>> Rev Pneumol Clin. 1992;48(3):115-9. Related Articles, Links [Metabolic acidosis in severe acute asthma. Effect of alkaline therapy] [Article in French] Bouachour G, Tirot P, Varache N, Harry P, Alquier P. Service de Reanimation medicale, C.H.R.U., Angers. Respiratory acidosis of severe acute asthma is a severity factor. In this paper the treatment of associated metabolic acidosis is discussed. Among 34 consecutive episodes of severe acute asthma with acidosis (pH < 7.35) treated with continuous adrenaline perfusion, theophylline and hydrocortisone hemisuccinate, respiratory acidosis was observed in 12, metabolic acidosis in 2 and mixed respiratory and metabolic acidosis in 20. The association of hypercapnic acidosis with hypochloraemic acidosis reflected a time of installation longer than when respiratory acidosis only was present (p < 0.05). Among the 22 patients who had metabolic acidosis on admission, 14 were treated with 168 +/- 82 mmol of sodium bicarbonate, the remaining 8 patients being untreated and acting as controls. The rapidity with which pH was corrected was the same in the treated and untreated groups (9.1 +/- 5.5 hours vs 6.7 +/- 3.7 hours), whereas dyspnoea (respiratory rate < 18/min) was more rapidly corrected in the treated group that in controls (11.6 +/- 5.7 hours vs 5.9 +/- 5.9 hours; p < 0.05). It is concluded that in more than 50% of the cases respiratory acidosis of severe acute asthma is associated with a metabolic acidosis. Correcting this metabolic acidosis with sodium bicarbonate results in improvement of respiration, perhaps by facilitating the action of bronchodilator catecholamines. PMID: 1332176 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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