J Toxicol Environ Health A. 2006 Feb;69(3):245-62. Links

Relationship between Radical Generation by Urban Ambient Particulate
Matter and Pulmonary Function of School Children.

Hogervorst JG, de Kok TM, Briede JJ, Wesseling G, Kleinjans JC, van
Schayck CP.

Research Institute CAPHRI.

The mechanisms by which particulate matter (PM) produces adverse
effects on the respiratory system, such as pulmonary dysfunction in
children, are largely unknown. However, oxidative stress is thought to
play an important role. Various chemical compounds in ambient
particulate matter, including transition metals and aromatic organic
compounds, may contribute to adverse effects through intrinsic
generation of reactive oxygen species (ROS). It was hypothesized that
ROS generation by PM, as determined through electron spin resonance
(ESR) spectroscopy, may be negatively associated with pulmonary
function in school children. PM(2.5), PM(10), and total suspended
particulates (TSP) were sampled at the playgrounds of six elementary
schools in the city of Maastricht, the Netherlands. All children (8-13
yr) from the six schools were asked to undergo spirometry. Multivariate
linear regression models were constructed to evaluate associations
between oxygen radical formation by PM and lung function. The
radical-generating capacity per microgram PM correlated negatively to
forced expiratory volume in 1 s (FEV(1)) and forced expiratory flow at
50% (FEF(50%)) of forced vital capacity (FVC). The data indicate that
chemical features that contribute to intrinsic generation of ROS may be
relevant for PM risk assessment.

PMID: 16263695 [PubMed - in process]

--------------------------------------------------------------------------------
Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking