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Medical Forum / Diseases and Disorders / Asthma / November 2005

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Climate change linked to rise in malaria, asthma

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Roman Bystrianyk - 02 Nov 2005 11:47 GMT
Timothy Gardner, "Climate change linked to rise in malaria, asthma",
Reuters UK, November 2, 2005,
Link:
http://today.reuters.co.uk/news/newsArticle.aspx?type=healthNews&storyID=2005-11
-02T023942Z_01_WRI184112_RTRIDST_0_HEALTH-ENVIRONMENT-CLIMATE-DISEASE-DC.XML&arc
hived=False


Climate change may promote the spread of deadly diseases like malaria
and asthma in both rich and poor countries by increasing the range of
parasitic insects and whipping up dust from storms, a new report says.

As climates warm, malaria is becoming more common in the traditionally
cool mountains of Africa, Asia and Latin America where 10 percent of
the world's people live, said Dr. Paul Epstein, the lead author of
"Climate Change Futures."

"Colonizers escaped (to mountainous areas) to avoid the swamps that
bred malaria. Those areas are no longer safe," Epstein told reporters
upon presenting the study, noting that malaria cases have quadrupled in
the past 10 years and kill 3,000 African babies a day.

Epstein, of the Harvard Medical School, wrote the report in
collaboration with reinsurer Swiss Re and the United Nations
Development Program.

The report warned that "malaria could suddenly swell in developed
nations, especially in those areas now bordering the margins of current
transmission."

Scientists believe greenhouse gases, such as carbon dioxide (CO2)
released by cars and utilities burning fossil fuels, lead to climate
change by trapping the sun's heat in the atmosphere. That can lead to
rising seas that may cause flooding and stronger storms.

Rising temperatures increase the range of the mosquitoes and ticks that
carry maladies like malaria, West Nile virus and Lyme disease, the
study said.

Cases of asthma, which is worsened by particulates in the air, can
increase from greater amounts of CO2, the report said. Plants high in
pollen and some soil fungi grow better with higher levels of the gas.

WICKED WINDS

In addition, climate change's stronger winds increase the amount of
dust in the air from expanding deserts, which compound the effects of
air pollutants and smog from the burning of fossil fuels as well as the
risks to asthma sufferers, it said.

That could increase the $18 billion that asthma and allergies cost the
U.S. health care system each year, according to the report, which lists
suggestions large companies could take to reduce their liabilities from
greenhouse gas emissions.

Last month, a federal judge dismissed a lawsuit from eight states and
New York City against five of the largest U.S. utilities claiming that
their emissions were a public nuisance and would cause property harm.
The case is on appeal.

The authors of the study hope to bring their findings to corporate
boards to reduce climate risks and liabilities.

Companies can lessen risks by joining markets that trade greenhouse
gases and by broadening their energy palate from coal and oil to
alternatives such as wind and solar power, and possibly, nuclear and
hydrogen power, Epstein said.

U.S. President George W. Bush dropped out of Kyoto Protocol on climate
change early in his first term.

The agreement created a carbon dioxide market in Europe that allows
companies that chose not to cut their greenhouse gases to buy credits
from companies that have.

The United Nations will hold climate talks later this month in Montreal
in which countries including the United States will discuss how to
proceed with the Kyoto Protocol.
Merlin - 03 Nov 2005 00:51 GMT
Good Morning Ramon, your post is very interesting and I have some
experience working in malarial areas and with persons who have been
inflicted with it.
One particular circumstance involved a middle-aged woman, she spent
only a few weeks in a low risk malarial area and returned to Australia.
Shortly after her return she showed odd symptoms and did not relate
those symptoms to her trip, they were not traditional malarial
symptoms.
She was treated with a couple of different antibiotics without any real
cure before being referred to a specialist and the Malaria was
confirmed. By this stage she had been very ill for a considerable time
and various treatments appeared to allow her recovery. She was able to
return to her job after some eight months sickness. At this time she
began having worsening bronchial problems and was diagnosed with
asthma.
The odd thing was that she had no previous problem and had a healthy
history.
She was given steroid medications plus all the other breathing machine
medications.
Over the next few years her problem worsened and now she is hard case
casualty, unable to work and has difficulty with day to day functions
with no real quality of life.
Any visitors are requested to be clear of any viral problems as her
resistance is zero.

As I read the above post it reiterated my original thoughts that more
than likely this particular womans tragic downfall would have involved
adverse antibiotic effect, coupled with the malaria.
The circumstantial elements were obviously present.
It is very ironic seeing your post mentioning the two problems
together, I do feel that antibiotics and asthma are undoubtedly
co-involved in an enormous amount of cases, most especially with young
children and have been observing this for more than thirty years.

Another chap I met had been in New Guinea for a short while and had
been using "DEET" based insect reppellent skin creams, rather than the
normal malarial prophylaxis. He had no asthmatic history but suddenly
became quite ill and was treated with antibiotics. He was eventually
determined to have "DEET poisoning" and had developed a chemical
sensitivity type asthma which he appears to have controlled before he
contracted severe Parkinson's. Some people just can't win!! To make it
worse his internal organs are "wasting" so he is "buggered". (age 64)
Goodness knows whether there is any relationship with the other
problems but the antibiotic treatment certainly "stands out", there was
no previous asthmatic history.

Cheers, Merlin.
Roman Bystrianyk - 04 Nov 2005 02:11 GMT
Merlin,

Thanks for those very interesting stories.  In regards to the malaria I
would like your opinion on this article I wrote a number of months ago.

Enjoy your day!
Roman

http://www.healthsentinel.com/org_news.php?id=025&title=Curcumin+Fights+Malaria&
event=org_news_print_list_item


oman Bystrianyk, "Curcumin Fights Malaria", Health Sentinel, February
17, 2005,

According to the World Health Organization (WHO), approximately 300
million people are affected each year by malaria resulting in roughly 1
to 1.5 million deaths worldwide. Previously extremely widespread,
malaria exists in 100 countries but is mainly confined to poorer
tropical areas of Africa, Asia, and Latin America. More than 90% of
malaria cases and the great majority of malaria deaths occur in
tropical Africa.

The parasite Plasmodium falciparum is the main cause of severe clinical
malaria and death. The parasites are transferred through the bite of
infected blood feeding female mosquitoes of the genus Anopheles. In
humans, parasites multiply exponentially in the liver and then in
infected red blood cells. Mosquitoes ingest parasites with a blood
meal, where the parasites undergo another reproductive phase inside the
mosquito before being passed on to another human.

The problems of controlling malaria in these countries are aggravated
by inadequate health structures and poor socioeconomic conditions. The
situation has become even more complex over the last few years with the
increase in resistance to the drugs normally used to combat the
parasite that causes the disease. Drug-resistance combined with limited
availability of antimalarials has contributed to the persistence of
this infectious disease.

Curcumin is the bright yellow flavonoid present in the spice turmeric
and is used in many Indian dishes. Curcumin has been shown to possess
anti-cancer, anti-oxidant, and anti-inflammatory properties. In
addition to these properties, curcumin has also been shown to have
anti-microbial activity. Curcumin has been found to be safe. It has
shown no signs of toxicity in humans in experimental trials taking over
3 months where participants took 8,000 mg of curcumin per day.

Now in the January 2005 issue of Biochemical and Biophysical Research
Communications the authors of a study demonstrate the anti-malarial
properties of this compound.

The scientists infected 2 groups of mice with Plasmodium berghei and
administered curcumin orally for 5 consecutive days, 48 hours after
infection in one of the groups. Plasmodium berghei is one of the many
species of malaria parasites that infect mammals other than humans. The
rodent parasites are not of direct practical concern to man or his
domestic animals. The interest of rodent malaria parasites is that they
are practical models for the experimental study of mammalian malaria.

The scientists found that the group that was given the curcumin had
their parasites reduced by more than 80% and completely protected 29%
of infected mice. Those mice that did not receive any curcumin all died
within 21 days.

The authors conclude, "curcumin appears to be an ideal antimalarial
molecule especially for use in combination with antimalarials such as
artemisinin not only to limit the use of the latter but to overcome the
problems of high cost, recrudescence [a new outbreak after a period of
inactivity], and drug resistance. In view of its abundance, non-toxic
nature, and demonstrated therapeutic effects in a variety of human
diseases, it will be useful to further investigate the potential of
curcumin in developing low-cost antimalarial therapies."

Source: Biochemical and Biophysical Research Communications, January
2005
Merlin - 06 Nov 2005 06:09 GMT
G'day Roman, Your paper is very interesting how long does this go back?
I am not sure of the name, but I suspect that is the same stuff that
some of my friends began using more recently. (In the past five years
or so) It required to be taken ideally for two weeks before leaving and
a week after their return as far as I can recall, but there was another
substance that needed less lead time. The side effect was that they
became yellow in their skin pigmentation and as far as I knew that was
the only problem. Some really white skinned women became quite brightly
coloured, so it was a bit of a joke. Tumeric would explain that, but
your article appears to indicate this is a more recent substance again.
As a lay-person I found it very enlightening.
Many of these mentioned people were long term residents in New Guinea
and Bougainville and places like that and it did cause problems needing
to use these kinds of things all the time but I don't know what they
were using specifically. There is even an odd malaria case from time to
time in the really northern tip areas of Australia, but this may be due
to people travelling across from NG. Some of these boats have a lot of
mossies in the bilges. Many places are now supposed to be clear,
Thailand is supposed to be one of these. I am not sure about Vanuatu
that is where the woman had been as mentioned earlier.
Personally I hated taking the earlier stuff, I think it was
chloroquinine but I am not sure.
I only took it for short periods because I was only in most places like
that for shorter periods. (Like a month or so) Most of the time I
avoided the real bad spots and haven't been to Africa or South America.

You would be aware that booze is a no-no with some of these things and
in the heat it was always nice to be able to have a nice cold beer if
that were possible, so one or the other was removed. Coincidently it
was obvious that teetotalers always had health problems of one kind or
another. Do you have any idea of alcohol effect with the curcumin? Some
of these indian families actually have curry for every meal, so they
must have quite a large intake of the tumeric. One place even had
"curry icecream" again bright yellow! (probably tumeric)
I always wore light coloured or white clothing, it was a most effective
mosquito deterrent with a trace of the insecticidal skin cream or
aerosol sprayed lightly overall.
Meticulous care with nets and burning insecticide coils at night was
normal.
I also liked to encourage gecko lizards, the translucent white fleshy
insect eating type, I actually made a point of catching and relocating
them. Oddly enough I have half a dozen of them here presently.
(Brisbane) I love watching them gobble insects, especially mosquitoes.

In some places I have seen aircraft tyres literally covered with
mosquitoes going for their life trying to get something, so there is
definitely something in the dark coloured items although I suppose the
tyres stored some heat and had a sofness similar to flesh. I expect an
infrared factor would have been involved.
You would appreciate the carbon dioxide theory which also appears "on
the money".
With friends that were unlucky enough to catch the bug it was never
suspected as being malaria initially because the symptoms they showed
were odd, similar to flu, that was the reason they received strong
repeated antibiotics, I believe this symptom is common now.
None died, but one is severely affected as mentioned, possibly from the
poor health, organ problems and other effects.
Dengue was a greater problem for me and was my worst experience, at the
time I was alone and really thought it was curtains. Luckily it was the
more common variety, not the haemorralgic type. I think the nick-name
"Breakbone fever" is an understatement.
I have some friends returning that have been on the topside of New
Guinea for a couple of years shortly so if there is anything of
interest I will repost it.
They have had no real problems apart from security which has become a
major concern there.
It is interesting to see the spice tumeric mentioned, as you are aware
it is a common spice used in Indian type curries often using meat which
may be "less than perfect" but produces a decent spicy meal which has
always been a fair element of my diet in these places, that may explain
why some indian families appeared to fare better than others.
Cholera and Typhoid was always my main worry as they kept appearing
every so often and I was always afraid of antibiotics unless as a last
resort.
One related interesting finding happened here a couple of years ago, a
clever experimenter designed an ultraviolet insect attractant which
contained a fan, and as the insects approached the trap, were caught in
a moving air current which allowed a centrifugal force effect to impel
the insects into a lowered surface tension, water trap, that air
continuued as another cycle so the fan power needed, was not all that
great.
A prior insect count before and after setting this machine, over a
large area an acre or so showed a reducton of insects better than
eighty percent. The machine was about the size of a four gallon drum.
The effect was startling and was noticed here mainly by homeowners in a
developing area realising they could venture outdoors without being
carried away by mosquitoes. The chap experimenting with the machine was
not aware of how efficient it was, or the potential clearing effect. Of
course the machine did require frequent emptying of the enormous amount
of insect carcasses.
You would also be aware of the insect strerilisation techniques being
used in some areas for mosquito control. These kinds of ideas together
have incredible potential but expense for lesser places would be a
problem. Here in Brisbane we have had a very successful mosquito
control method by aerial spraying of swamp areas but it needed constant
repetition and care with timing because of neap tidal effects and
breeding cycles, wind drift and all the rest made it a complicated
procedure.
In some tropical areas as sunset approaches the mosquito populations
are so vast that they resemble a cloud of smoke eneveloping enormous
areas and if you are unlucky enough to get caught by it you really go
through a lightspeed learning experience. I was silly enough to watch
this phenonomenon come toward me from about a kilometer distant and
suddenly being inundated by millions of biting mosquitoes, and they bit
through your clothes, and you try to hop around slapping your face and
every breath is even full of mosquitoes! So by the time you start
breathing through a handkerchief and try to cover or move to improve
your situation you are being bitten all over your body, I was lucky to
be able to make it back to my car and had a can of spray, so having the
respite sat incredulous as to how a circumstance like this could happen
so simply. It was terrifying.
I don't know much about the anopheles but would imagine it would be
ultraviolet sensitive.
The other one is of course this aedi egypti (spelling) which is of
course another matter.
Quite obviously with warming comes moisture retention, and increased
severity weather conditions, so mosquito populations logically will
increase as will disease problem potential.
I think the account of the Panama Canal construction is an amazing
story where intelligence outside the normal square was the means for
achieving success.
Your account is very comprehensive with logical conclusions, with my
limited knowledge it is very enlightening. Thankyou for the
information.
Cheers, Merlin.
Roman Bystrianyk - 08 Nov 2005 01:36 GMT
Good day Merlin!

Thanks for the interesting reply.  The news article was based on a
January 2005 research paper.  It was done in rats so I am very
interested in your stories of people taking turmeric (if that was in
fact what they were taking).   I am very interested in the results they
had if any that you know of.  I am not familiar with any effects of
turmeric with alcohol.  The story of the swarm of mosquitoes was
amazing - sounds simply horrifying!

I was also quite interested in that mosquito trapping invention.
Sounds fascinating and a potentially wonderful alternative to spraying
if it is that effective.  Please tell me more via my email
rbystrianyk@healthsentinel.com.

Roman
Merlin - 08 Nov 2005 10:38 GMT
G'day Roman , reply sent.
Cheers, Merlin
 
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