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Medical Forum / Diseases and Disorders / Asthma / November 2005Restrictive lung disease / serum ferritin / iron
Asian Pac J Allergy Immunol. 2005 Jun-Sep;23(2-3):121-6. Related Articles, Links Restrictive lung disease and serum TGF-beta1 in thalassemia major children. Sritippayawan S, Lekhanont P, Harnruthakorn C, Samransamruajkit R, Deerojanawong J, Seksarn P, Poovorawan Y, Prapphal N. Division of Pulmonology and Critical Care Medicine, King Chulalongkorn Memorial Hospital, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. suchadacu@hotmail.com A cross sectional study was performed in 21 thalassemia major (TM) children at King Chulalongkorn Memorial Hospital during March to August, 2003 to determine whether restrictive lung disease (RLD) was related to serum transforming growth factor-beta 1 (TGF-beta1). All studied patients (57% female, age 11.2 +/- 2.6 yrs, duration of transfusion 7.7 +/- 4.1 yrs) never had desferoxamine treatment and their pulmonary function, serum ferritin and serum TGF-beta1 were evaluated. Five (24%) had RLD. RLD patients had significantly longer durations of transfusion and higher serum ferritin levels than non-RLD patients (9.1 +/- 1.9 vs 5.5 +/- 3.2 yrs; p = 0.03 and 3,816.6 +/- 1,715.9 vs 2,084.5 +/- 1,504.8 ng/ml; p = 0.04, respectively). TM children had lower serum TGF-beta1 levels than normal children (7.9 vs 78.8 pg/ml; p < 0.001). The serum TGF-beta1 level was not different between RLD and non-RLD patients (13.3 vs 4.2 pg/ml; ns), concluding that RLD was related to longer duration of transfusion and higher serum ferritin but not related to serum TGF-beta1 levels. PMID: 16252842 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "RLD was related to longer duration of transfusion and higher serum ferritin " So, what about transfusions made the level of this disorder higher and caused higher iron levels to follow? Now .. put down your mindset of puke .. and pickup your mindset of medical cop .. Transfusions are NOTORIOUS for raising iron levels in the body .. raising .. ferritin levels .. This is due to the increased iron from the red blood cells that die and are replaced by transfusions .. So in this one would use what you might call .. 'circumstantial evidence' .. that .. the ferritin rise is DUE TO .. the iron from the transfusions .. So .. when compared to OTHER studies .. the increased iron is ALSO found in asthma .. which IS / has been SHOWN to BE .. 'related' .. to .. RLD .. Soooooooo .. More evidence .. Tis all .. And you seem to have a problem with it .. You seem to have some sort of .. agenda .. Heh .. heh .. what about transfusions made the level of this disorder higher and caused higher iron levels to follow<< Answer your own question .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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