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Medical Forum / Diseases and Disorders / Asthma / November 2005Autoimmune disease / vitamin E
Br J Nutr. 2005 May;93(5):655-62. Related Articles, Links The effects of vitamin E supplementation on autoimmune-prone New Zealand black x New Zealand white F1 mice fed an oxidised oil diet. Hsieh CC, Lin BF. Laboratory of Nutritional Chemistry, Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan 10764, Republic of China. The purpose of the present study was to investigate the effect of vitamin E supplementation on autoimmune disease in New Zealand blackxNew Zealand white F1 (NZB/W F1) female mice fed an oxidised oil diet. First, 5-month-old mice were fed an AIN-76 diet containing either 150 g fresh soyabean oil/kg (15S), 50 g fresh soyabean oil/kg + 100 g oxidised frying oil/kg (5S10F) or 5S10F supplemented with all-rac-alpha-tocopheryl acetate at 275 mg/kg diet level (5S10F5E) or 550 mg/kg (5S10F10E), respectively, in experiment 1. The results showed that mice fed the 5S10F10E diet had a lower anti-double-stranded DNA IgG antibody level and a longer lifespan than those fed the 15S and 5S10F diets. Therefore, the 5S10F and 5S10F10E treatments were repeated in experiment 2 for further analysis. The results showed that vitamin E supplementation in the oxidised oil significantly decreased thiobarbituric acid-reactive substance values in the kidney and spleen of NZB/W F1 mice. Interferon-gamma and IL-6 production by mitogen-stimulated splenocytes decreased in mice fed the 5S10F10E diet, whereas the secretion of IL-2 and IL-10 was not affected. The percentage of T-cells was significantly higher and that of MHC class II-bearing cells was lower in the spleens of the 5S10F10E group. The 5S10F10E group had a significantly higher linoleic acid (18 : 2n-6) composition than the 5S10F diet group. Therefore, vitamin E supplementation in oxidised oil might decrease oxidative stress, anti-double-stranded DNA IgG antibody, regulate cytokines and lymphocyte subsets, and subsequently alleviate the severity of autoimmune disease such as systemic lupus erythematosus under oxidative stress. PMID: 15975164 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Oh, hell. He's loose again. . . > Oh, hell. He's loose again. . . In the same sense as a stool. >> Oh, hell. He's loose again. . . > > In the same sense as a stool. Good one. :-) hee, hee! jeff > > Oh, hell. He's loose again. . . > > In the same sense as a stool. I'm still trying to decipher the post. Mary > hee, hee! > jeff > > > > > Oh, hell. He's loose again. . . > > > > In the same sense as a stool. >> Oh, hell. He's loose again. . . > >In the same sense as a stool. Yes, he is a real straight shooter, especially when it has to doo with medical advice... http://home.earthlink.net/~slamcast/media/bios/drdrhea.gif > >> Oh, hell. He's loose again. . . > > > >In the same sense as a stool. > > Yes, he is a real straight shooter, especially when it has to doo > with medical advice... Butt he makes too many cheeky cracks and doesn't know squat about his own posts. When he gets on a roll, it's enough to tissue off. It's ultimately much turd doo about nothing. Right -on...thats good news....thanks a million > Br J Nutr. 2005 May;93(5):655-62. Related Articles, Links > [quoted text clipped - 49 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking Speaking of stool>>>>>> > Right -on...thats good news....thanks a million >> Br J Nutr. 2005 May;93(5):655-62. Related Articles, Links The natural vitamin E helped me alot Satn J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):88-93. Epub 2005 Apr 19. Related Articles, Links Suppression of murine cerebral F(2)-isoprostanes and F(4)-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol. Milatovic D, Vanrollins M, Li K, Montine KS, Montine TJ. Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA. Oxidative damage to brain is a featured shared by several destructive and degenerative diseases and is thought to contribute to disease pathogenesis. Two commonly proposed sources of the increased free radical stress that leads to oxidative damage in several of these diseases are excitotoxicity and activation of innate immunity, both of which are proposed pharmacologic targets. Here we used models of excitotoxicity, intracerebroventricular (ICV) kainate (KA), and innate immune activation, ICV lipopolysaccharide (LPS), to test the effectiveness of peripherally administered alpha-tocopherol (AT) and gamma-tocopherol (GT) as neuroprotectants. We quantified murine cerebral oxidative damage by measuring F(2)-isoprostanes (IsoPs) and F(4)-neuroprostanes (NeuroPs) using stable isotope dilution methods followed by gas chromatography-mass spectrometry with selective ion monitoring. Our data showed that peripherally administered AT and GT were equally effective at suppressing acute oxidative damage from direct excitotoxicity caused by KA. In contrast, peripherally administered AT, but not GT, was effective at suppressing delayed neuronal oxidative damage from activated glial innate immune response. These data imply that AT may be more broadly protective of cerebrum from oxidative damage in different disease contexts. PMID: 16260380 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking What part of "Get Lost" don't you understand? Nobody wants you around here, or anywhere else. So, get lost already yet. Sylvia |
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