 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / Diseases and Disorders / Asthma / October 2005Iron homeostasis / air pollution
Inhal Toxicol. 2005 Dec;17(13):709-16. Links Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles. Ghio AJ, Cohen MD. Clinical Research Branch, Human Studies Division, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Several features of the clinical presentation and changes in physiology and pathology following exposure to many diverse ambient air pollution particles are comparable, suggesting a common mechanism for their biological effect. We propose that a mechanism of biological effect common to many ambient air pollution particles is a disruption of iron homeostasis in cells and tissues. Among traits shared by every particle-related lung injury is the introduction of a solid-liquid interface into the respiratory tract. All surfaces of particulate matter have some concentration of oxygen-containing functional groups. As a result of its electropositivity, Fe(3+) has a high affinity for oxygen-donor ligands and will react with these groups at the particle surface. Retained particles accumulate metal from available sources in a cell and tissue, and this complexed iron mediates oxidant generation. In addition to complexation onto the solid-liquid interface provided by the surface of particulate matter (PM), there are several alternative pathways by which metal homeostasis in the lower respiratory tract can be disrupted following exposure to ambient air pollution particles to affect an oxidative stress. Evidence suggests that disruption in iron homeostasis following exposures to ambient air pollution particles is an initial event in their biological effect. An association between metal equilibrium in the lower respiratory tract and biological effect in the lung could explain the observed differential toxicity of ultrafine, fine, and coarse particles and disparities in host susceptibility. PMID: 16195206 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking this is interesting but whats it mean in laymans terms? > Inhal Toxicol. 2005 Dec;17(13):709-16. Links > [quoted text clipped - 47 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking >this is interesting but whats it mean in laymans terms? Basically, in layman's terms, the poster is a fool, hopelessly trying to iron out his homostasis, while peering dimly through a rusted and corroded vision of one gone awry. In professional terms, he is a sociopath. In real terms, well, you know plenty of real terms. >this is interesting but whats it mean in laymans terms? Basically, in layman's terms, the poster is a fool, hopelessly trying to iron out his homostasis, while peering dimly through a rusted and corroded vision of one gone awry. In professional terms, he is a sociopath. In real terms, well, you know plenty of real terms. << In other words .. Bob doesn't know .. either .. Heh .. heh .. I believe this would be the operative .. couple of words .. <<snip>> metal equilibrium in the lower respiratory tract <<snip>> Which would mean .. the more iron IN the lung .. the more chance of a .. 'reaction' .. How are elevated iron levels in the lung .. achieved .. ? Take a .. guess .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Man Is A Herbivore! > http://pages.ivillage.com/ironjustice/manisaherbiore > > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplwalking I guess this makes you the ivillage idiot? Village idiot? Hmm. Horse's a.s. |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.