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Medical Forum / Diseases and Disorders / Arthritis / March 2005Uric acid / gout / IRON
Free Radic Res. 2005 Mar;39(3):337-42. Related Articles, Links The association between serum ferritin and uric acid in humans. Ghio AJ, Ford ES, Kennedy TP, Hoidal JR. National Health and Environmental Effects Research Laboratory Office of Research and Development, Environmental Protection Agency Research Triangle Park, NC 27711 USA. Objective: Urate forms a coordination complex with Fe(3+) which does not support electron transport. The only enzymatic source of urate is xanthine oxidoreductase. If a major purpose of xanthine oxidoreductase is the production of urate to function as an iron chelator and antioxidant, a system for coupling the activity of this enzyme to the availability of catalytically-active metal would be required. We tested the hypothesis that there is an association between iron availability and urate production in healthy humans by correlating serum concentrations of ferritin with uric acid levels. Materials and methods: The study population included 4932 females and 4794 males in the National Health and Nutrition Examination Survey III. They were 20 years of age or older and in good health. Results: Serum concentrations of ferritin correlated positively with uric acid levels in healthy individuals. This association was independent of an effect of gender, age, race/ethnic group, body mass, and alcohol consumption. Conclusions: The relationship between serum ferritin and uric acid predicts hyperuricemia and gout in groups with iron accumulation. This elevation in the production of uric acid with increased concentrations of iron could possibly reflect a response of the host to diminish the oxidative stress presented by available metal as the uric acid assumes the empty or loosely bound coordination sites of the iron to diminish electron transport and subsequent oxidant generation. PMID: 15788238 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://herbivore.7h.com <stuff Tom doesn't understand snipped> Tom, that article only applies to people with haemocromatosis, not to the general population. Once again, you've shown you're unable to read and comprehend (or more probably either of those things in isolation, the combined activity being far beyond your means) what you're copy and pasting. Here's an idea: go to school, get a degree, and run an experiment! Wait... No.... You're an imbecile, that'll never happen... Oh well, time for you to go back to your compulsive masturbating again. All the best!  Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ WHERE does it say .. hemochromatosis .. ? It doesn't .. say .. hemochromatosis .. <<snip>>Results: Serum concentrations of ferritin correlated positively with uric acid levels in HEALTHY INDIVIDUALS <<snip>> YOU .. think .. it SAYS ... hemochromatosis .. ? That means you are .. stupid .. Doesn't .. it .. But that is evidence .. based .. Eh .. Who loves ya. Tom Jesus Was A Vegetarian! http://herbivore.7h.com > WHERE does it say .. hemochromatosis .. ? > [quoted text clipped - 7 lines] > > That means you are .. stupid .. No, it means you're retarded: "Conclusions: The relationship between serum ferritin and uric acid predicts hyperuricemia and gout in groups with iron accumulation." You don't even understand two words put together: iron accumulation. Lol idiot Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ "Conclusions: The relationship between serum ferritin and uric acid predicts hyperuricemia and gout with iron accumulation" You don't even understand two words put together . iron accumulation.<< The uric acid rises AS the iron rises .. That would mean .. yes .. iron accumulation IS .. involved .. simply BECAUSE .. iron was the mineral they were watching .. Now since the individuals ARE .. healthy .. therefore .. NO .. *genetic* .. iron overload / iron accumulation .. then the rise in uric acid which rises AS .. the .. IRON .. rises .. is .. RISING .. because .. the IRON .. is rising .. DUE TO .. environmental causes .. which would INCLUDE .. ingestion .. eating .. OF .. iron .. I suppose THAT would explain why bloodletting is shown to be EFFECTIVE .. in .. gout .. Eh .. But THAT would be too hard for YOU to understand .. Since you ARE .. stupid .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://herbivore.7h.com > "Conclusions: The relationship between serum ferritin and uric acid > predicts hyperuricemia and gout with iron accumulation" > > You don't even understand two words put together . iron accumulation.<< > > The uric acid rises AS the iron rises .. In healthy people, yes. But healthy people don't have iron accumulation, genius. The only gout->iron link is in people with iron accumulation who MAY according to that study develop high uric acid levels. Like I said, if you had the intellectual means, you'd actually get an education and conduct these experiements rather than just copy and pasting things you've misunderstood. cheers! Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ >>rather than just copy and pasting things you've musunderstood<< The iron in healthy humans rises parallel TO the uric acid .. the iron in people with iron accumulation parallels the uric acid levels .. So .. unless .. you are VERY stupid .. one can ..understand .. that is .. U-N-D-E-R-S-T-A-N-D .. the iron levels parallel the uric acid levels .. Do you know what parallel .. means .. or are you ALSO too stupid to use a dictionary .. It means .. 'goes along hand in hand' .. so .. as I said before .. the iron rises as the uric acid rises or the uric acid rises as the iron rises .. Too easy for ya .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://herbivore.7h.com >>>rather than just copy and pasting things you've musunderstood<< > > The iron in healthy humans rises parallel TO the uric acid .. Wrong. The uric acid MAY rise with ferritin, an indirect measure of iron content that is also a liver inflamatory protein. > the iron > in people with iron accumulation parallels the uric acid levels .. No, it doesn't. My uric acid levels are low. I have massive iron stores and extremely high ferritin. You're still not understanding, but then again, you never do. And no, you cannot send me any more photographs. That was some sick stuff. You need help. Signaturespammage trappage: replace fishies_ with yahoo I'm going to die rather sooner than I'd like. I tried to protect my neighbours from crime, and became the victim of it. Complications in hospital following this resulted in a serious illness. I now need a bone marrow transplant. Many people around the world are waiting for a marrow transplant, too. Please volunteer to be a marrow donor: http://www.abmdr.org.au/ http://www.marrow.org/ > Tom, that article only applies to people with haemocromatosis,... > Here's an idea: go to school, get a degree, and run an experiment! He has to earn his dipolma from kindergarten, then junior high school, the senior high school before he can get a degree. ... Tom thought the town hooker was into needlecraft. |
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